Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 162 for “"sensory neurons"”.
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Angiotensin II signalling in sensory neurons
… – and the presence of receptors for Ang II on sensory neurons may point to additional roles in nociception in inflammatory disease. Work in this Thesis sought to examine the identity of sensory neurons with which Ang II interacts, the mechanisms underpinning these interactions, and the …
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Temporal Processing by Caenorhabditis elegans Sensory Neurons
… to be established. We show that C. elegans chemosensory neurons can operate in a highly deterministic and low-noise mode, and they act as reliable linear filters of their input. We then use dynamical systems analysis in combination with classical genetic perturbation to uncover cellular and …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
Neurotrophins regulate sensory neuron survival, differentiation and phenotype, yet much remains to be discovered. The role of neurotrophins and neurotrophin receptors in adult primary sensory neurons was investigated along three main avenues 'in vivo'. First, to better predict neurotrophin …
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Axon Development and Synapse Formation in Olfactory Sensory Neurons
… proliferate and differentiate into olfactory sensory neurons (OSNs) that project their axons to the olfactory bulb (OB) where they establish connections to the central nervous system. The olfactory epithelium is therefore an attractive model for the study of axonal growth and synapse …
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Minimum-error, energy-constrained source coding by sensory neurons
Neural coding, the process by which neurons represent, transmit, and manipulate physical signals, is critical to the function of the nervous system. Despite years of study, neural coding is still not fully understood. Efforts to model neural coding could improve both the understanding of the …
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Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons
… protein kinase (p38 MAPK) in <em>Aplysia</em> sensory neurons. These two MAPKs have competing roles in the induction of LTF, with ERK promoting LTF and p38 MAPK opposing it. Further characterization of the effects of DOX on the basal state of neurons may aid the understanding of how DOX …
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Distribution and function of TRP ion channels in primary sensory neurons
… CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The CB1 receptor agonists anandamide and HU210 also fail to inhibit …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… of tuft cells with trigeminal sinonasal neurons in the context of allergic disease remain largely unexplored and unclear. This study investigated the impact of intranasal administration of house dust mite or fungal allergens on these cells and sought to understand the mechanisms …
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Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
… the small-molecule drug KU-32 ameliorates psychosensory, electrophysiologic, morphologic, and bioenergetic deficits of DPN in animal models of type 1 diabetes. The current study used mouse models of type 1 and type 2 diabetes to determine the relationship of changes in sensory neuron …
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Mechanisims of prostacyclin-induced modulation of neuropeptide release from rat sensory neurons grown in culture
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… neurochemical changes occurring in primary sensory neurons, the effects of a single-dose intravenous administration and a well-established “chronic” schedule (three times/week for 8 weeks) in a rat model of bortezomib-induced peripheral neuropathy have been examined. The …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… cells, but it is also capable of infecting neurons where it can pursue a lytic or latent infection. Latency is a state of viral quiescence where the virus can persist indefinitely yet remain poised to reactivate. Latency is unique to herpesviruses and key to HSV's success, but the molecular …
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Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons
… infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and animal models. The viruses preferentially …
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Identification of potassium channel subtypes mediating the PGE2-induced sensitization of sensory neurons and regulation of potassium channel gene expression by chronic inflammation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Functional Analysis of SOX11 and NF1 in Sensory Neuron Development and Plasticity
Development of sensory neurons is controlled by both cell-extrinsic and cell-intrinsic factors. The transcription factor Sox11 is abundantly expressed in embryonic sensory neurons. In the first part of this thesis, by using a Sox11-/- mouse model, I show that the loss of Sox11 results in increased …
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Sensory Coding and Olfactory Integration in Caenorhabditis Elegans
… from its environment? Here, I ask how multiple sensory neurons drive and shape one interneuron's activity. C. elegans senses several odors, including the bacterial metabolite diacetyl, using the AWA sensory neurons. AWA forms chemical and electrical synapses onto several interconnected …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In mammals, inner ear sensory cells undergo terminal mitosis during embryogenesis and do not regenerate. Therefore, during postnatal life, sensory cell loss is a …
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Transcriptional control of somatosensory neuron diversification in Drosophila
Primary sensory neurons deliver information from the periphery to specific circuits in the central nervous system. It is vital that each sensory neuron detects the appropriate type of stimulus and conveys that information to appropriate regions of the sensory neuropil to target second-order …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… involved in cold transduction in peripheral neurons. Members of the transient receptor potential (TRP) family of cation channels are currently recognised as the principal transducers of thermal stimuli in sensory neurons, and two channels, TRPM8 and TRPA1, have been implicated in cold …
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