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Showing 1 to 14 of 14 for “"sensory hair cells"”.
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Light Stimulation of Sensory Hair Cells
<p>Hair cells are the mechanosensory detectors that underlie our senses of audition and balance. Their mechanosensitivity arises from direct gating of force-sensitive ion channels by the tension in tip links located at the tops of the stereocilia. The study of hair cells and their mechanically …
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Gentamicin and FM1-43 enter sensory hair cells through mechanosensory transduction channel
… ototo.xic aminoglycoside antibiotic drugs, into sensory hair cells: permeation through the transduction channels. Both gentamicin, an aminoglycoside, and FM1-43, a styryl pyridinium dye, rapidly and selectively enter hair cells. The hair cell transduction channel passes monovalent cations, but is …
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The Reinnervation of Sensory Hair Cells Following Lesion of the Lateral Line Cranial Nerve
<p>Loss of hearing is a prevalent sensory pathology in the United States and worldwide. A significant proportion of deafness is attributed to sensorineural hearing loss, which often involves damage and retraction of the nerve fibers that relay auditory information between the mechanosensitive hair …
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Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
Mechanosensory hair cells convert mechanical information into neuronal signals. Mutations in the genes required for hair cell function cause deafness and lead to the degeneration of sensory hair cells. Mammals are unable to regenerate these cells, leading to the permanent loss of hair cells. …
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Genomic Approaches for Pathway Identification in Regenerating Sensory Epithelia of the Inner Ear
The inner ear utilizes sensory hair cells as mechano-electric transducers for sensing sound and balance. In mammals, these sensory hair cells lack the capacity for regeneration and if damaged lead to hearing or balance disorders. However, non-mammalian vertebrates such as birds maintain their …
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Adenoviral Mediated Gene Delivery to Human Umbilical Cord Mesenchymal Stromal Cells for Inner Ear Hair Cell Differentiation
Hearing is one of our main sensory systems and having a hearing disorder, although not life threatening, can have a disturbing impact in an individual's quality of life. Approximately 49 million Americans suffer from some form of hearing loss. Sensory neural hearing loss (SNHL) is the most common …
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Robustness Enhancement of Sensory Transduction by Hair Bundles
… be made robust to parameter perturbation. The sensory hair cells of the cochlea are physiologically vulnerable: small changes in parameter values could compromise hair cells' ability to detect stimuli. Most ears, however, remain highly sensitive despite differences in their physical properties. …
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Hearing Sensitivity and the Effect of Sound Exposure on the Axolotl (Ambystoma Mexicanum)
… genetics, and regeneration. Although the sensory hair cells of the lateral line of this species have been shown to be able to regenerate, it is not known whether this also occurs in the inner ear. In fact, little is known about the hearing capabilities of the axolotl or other salamander …
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Tuning of the Active Hair Bundle
… ear rely upon a population of several thousand sensory hair cells to amplify and transduce acoustic, seismic, and kinesthetic signals. Each hair cell detects mechanical disturbances by means of its hair bundle, a motile organelle consisting of actin-filled, villous projections (called …
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Auditory Hair Cell Regeneration and Gene Expression in Noise-Exposed Zebrafish (Danio rerio)
Fishes are capable of regenerating sensory hair cells in the inner ear after exposure to excessive noise. However, a time course of auditory hair cell regeneration has not been characterized for zebrafish, nor has gene expression following noise exposure. To establish a time course of hair cell …
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The Role of the Stereociliary Glycocalyx in Hair Bundle Cohesion
<p>The sensory hair cells of the inner ear are exquisitely sensitive machines that translate the broad dynamic range of sound intensities in our auditory landscape into the electrical language of neurons. The mechanosensitive organelle of the hair cell is the hair bundle, a cluster of linked, …
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The functional role of tectorial membrane poroelasticity in cochlear mechanics
… matrix that overlies the mechanically sensitive hair bundles of sensory receptor cells in the inner ear. Based on this strategic position, it has long been accepted that the TM plays a critical role in the stimulation of sensory hair cells. Early measurements demonstrated elastic properties of …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In mammals, inner ear sensory cells undergo terminal mitosis during embryogenesis and do not regenerate. Therefore, during postnatal life, sensory cell loss is a …
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THE ROLE OF NOTCH SIGNALING IN THE DIFFERENTIAL ABILITY OF SUPPORTING CELL SUBTYPES TO SPONTANEOUSLY REGENERATE HAIR CELLS IN THE NEONATAL MOUSE COCHLEA
… to this loss in hearing is the loss of the sensory hair cells (HCs) within the cochlea. Also in the mammalian cochlea, six major groups of supporting cell (SC) subtypes reside in close proximity to HCs and may have the potential to regenerate HCs after damage. These subtypes include cells of …