Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"sensory cells"”.
-
The effect of hair bundle shape on hair bundle hydrodynamics of sensory cells in the inner ear
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
-
Role of the lateral olivocochlear efferent system in hearing : selective lesioning studies
Sensory cells and afferent auditory neurons in the cochlea receive efferent feedback via olivocochlear (OC) neurons originating in the brainstem's olivary complex. The OC system comprises 1) medial (M)OC neurons that decrease electromotility in outer hair cells, and 2) lateral (L)OC neurons that …
-
Connectome and Ultrastructural Studies of an Anthozoan Planula: Exaiptasia diaphana
… ancestor. I reconstructed and annotated 1,285 cells in a whole-body serial EM dataset, identified 16 cell types and mapped their anatomical distribution. I describe specific features of epithelial, gland, stinging, sensory cells and neurons. Different kinds of synapses and their circuits are …
-
Using knockout mice to study the molecular mechanisms that shape auditory nerve responses
… primary afferents connecting cochlear inner hair cells to the brain. This thesis provides the first systematic analysis of fundamental response properties of the mouse AN, including rate and timing of spontaneous and sound-evoked discharge, frequency selectivity, dynamic range, and the relations …
-
GENETIC DISSECTION OF AVERSION TO ALLYL ISOTHIOCYANATE IN Drosophila melanogaster
… We observed an absence of colocalization in sensory cells in the legs. We also expressed UAS-ORK, which electrically silences cells, in sensory neurons, to evaluate the necessity of dTRPA1 and painless cell populations. Using all four behavioral assays, we determined the outputs from both …
-
Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… Adeno-associated virus mediated transduction of sensory epithelia within the guinea pig cochlea Chairperson: Dr. David J. Poulsen, PhD. Hearing loss is the most common disability of the senses and affects 250 million people worldwide. This condition is often caused by the degeneration of the …
-
Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… Adeno-associated virus mediated transduction of sensory epithelia within the guinea pig cochlea Chairperson: Dr. David J. Poulsen, PhD. Hearing loss is the most common disability of the senses and affects 250 million people worldwide. This condition is often caused by the degeneration of the …
-
EXPRESSION AND MISEXPRESSION OF THE MIR-183 FAMILY IN THE DEVELOPING HEARING ORGAN OF THE CHICKEN
… required for the proper maturation of primary sensory cells in both the inner ear and the retina in mammals. The miR-183 family shows dynamic longitudinal and radial gradients in the developing mouse cochlea, which raises a question whether the microRNA levels play a role in specifying hair …
-
Investigation of the Function of the Olivocochlear Efferent Nerve Pathway in Humans
… and frequency selectivity. A population of sensory cells, called the outer hair cells, are the primary effectors of the active process, and can alter their length and stiffness dynamically. The outer hair cells are also innervated by the efferent nerve pathway descending from the region of …
-
Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In mammals, inner ear sensory cells undergo terminal mitosis during embryogenesis and do not regenerate. Therefore, during postnatal life, sensory cell loss is a …
-
Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… cochlear function and protecting auditory sensory cells. Changes in microRNA expression have been linked to different types of hearing loss, including age-related, noise-induced, and genetic or congenital. Our lab focuses on the miRNA-183 family, which includes three microRNAs: miR-183, …
-
Stochastic dynamics in olfactory signal transduction and development
… by a complex chemical network in the sensory cells with the task of coding the available information reliably over a wide range of stimulus strength. In the present work, methods from nonlinear dynamics combined with network theory (namely stoichiometric network analysis) are used to …
-
Daple Orients and Patterns Sensory Hair Bundles in the Inner Ear
<p>The planar orientation of mammalian cells necessitates the integration of diverse pathways. In the inner ear, at least two systems regulate the planar polarity of the hair bundle. The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells across the epithelial plane. …