Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 364 for “"sensitivity and specificity"”.
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… (PDAC) is challenging due to asymptomatic nature and deep location of the malignancy within the abdomen. The development of PDAC consists of three different pathways but two arise from the duct, Pancreatic Intraepithelial Neoplasia (PanIN) and Intraductal Papillary Mucinous Neoplasm (IPMN). During …
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Sensitivity and Specificity of Three Phase Bone Scan in the Complex Regional Pain Syndrome according to the Disease Progress
… difficult to diagnose in chronic pain field and diagnosed by purely clinical criteria based on characteristic symptoms and signs, Three phase bone scan (TPBS) is one of the objective tools in diagnosis of CRPS. However, TPBS cannot confirm CRPS and has limited role in diagnosis of CRPS. The …
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Computer-assisted auscultation as a screening tool for cardiovascular disease : a cross-sectional study
… is inherently qualitative, highly subjective and requires considerable skill and experience. Computer- assisted auscultation (CAA) is an objective referral-decision support tool that aims to minimise inappropriate referrals. This study evaluated the sensitivity and specificity of 2 CAA …
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Remote Neuropsychological Assessment: Does Mode of Administration Matter?
<p>Neuropsychology relies heavily on standardization of administration to increase the validity, reliability, sensitivity, and specificity of an assessment instrument. The COVID-19 pandemic has rapidly increased the need to be able to provide neuropsychological assessments remotely. …
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The Validity of the Alcohol, Smoking and Substance Involvement Screening Test in Patients with Psychotic Disorders
… resultant negative health consequences, a brief and easily administered screening test is needed in this population to identify those at risk in order to intervene appropriately. The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) was developed by the World Health Organisation …
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Spatiotemporal Encoding Methods for Brain Magnetic Resonance Imaging
… imaging technology for both clinical diagnosis and neuroscientific research. However, the imaging sensitivity and specificity of brain MRI are limited by the well-known technical challenge of MRI acquisition—low image encoding efficiency, leading to limited acquisition speed, spatial resolution …
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MRT-Leberdiagnostik mit dem leberspezifischen Kontrastmittel Gd-EOB-DTPA
… After that liver-specific imaging is possible. Sensitivity and specificity in unenhanced MRI were 83% and 100% and could be increased to 91% and 98% by Gd-EOB-DTPA administration. Sensitivity and specificity in contrast-enhanced spiral-CT were 73% and 100%. Characterization rate could be …
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Novel Incorportation Of Biomedical Engineering Algorithms (bispectral Index Guided Or Anesthetic Concentration Guided) In Real-Time Decision Support To Prevent Intraoperative Awareness Using An Electronic Anesthesia Information Mananagement System
… the use of intravenous anesthetics was developed and retrospectively applied to previously collected data. A threshold was calculated that demonstrated optimal sensitivity and specificity for detecting AWR. Next, a large prospective randomized controlled trial was performed in an unselected …
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Comparison of different differential expression analysis tools for rna-seq data
… huge amount information about the variety and abundance of RNA present in an organism of interest at a specific state and a given time. One of the most important tasks of RNA-seq analysis is finding genes that are expressed differently in different subject groups. A lot of differential …
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Validation of the CAT rapid: a smartphone screening tool for HIV-associated neurocognitive disorders in South Africa
… of HIV-associated neurocognitive disorders (HAND) in South Africa. Study 1 of the current thesis aimed to establish construct validity of a new screening tool, the Cognitive Assessment Tool-Rapid(CAT-Rapid), in a sample of cognitively healthy South African undergraduates (n = 122).Study 2 …
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Engineering functionalized gold nanoparticles as a molecular-specific contrast agent to enhance optoacoustic detection of breast cancer cells
… could potentially revolutionize the diagnosis and treatment of many types of cancer including breast. Delivering molecular specific contrast agents to breast cancer cells would enhance the sensitivity and specificity of imaging methods to detect cancer foci at earlier stages, when complete cure …
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Machine learning classifiers for critical cardiac conditions
… diagnosing cardiac conditions require a manual and visual analysis of ECG and heart rate (RR interval) data. In this thesis, novel features and machine learning classifiers are developed for automating the detection of Congestive Heart Failure (CHF) and Atrial Fibrillation (AFIB). These …
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Liquid Chromatography – Mass Spectrometry for Protein Biomarker Discovery in Pancreatic Adenocarcinoma
… to simulate the tumor microenvironment in vitro and produce a proteome rich in biomarkers. The proteins identified demonstrate the complex signals tumor cells use to communicate with their environment and encompass therapeutic targets and biomarkers. To assay these proteins in serum, a relative …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
… species, <em>Trypanosoma brucei gambiense</em> and <em>T. b. rhodesiense</em>. Clinical diagnosis is not sufficient as symptoms from other endemic diseases, such as Malaria, are similar. Currently the diagnosis of <em>T. b. gambiense</em> infection mainly relies on the Card Agglutination Test …
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A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma
… encountered in South African trauma units, and is associated with high mortality and morbidity rates. The imaging protocol for stable patients with penetrating neck trauma remains controversial. There is only sparse data validating the use of Computed Tomography Angiography (CTA) in the …
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Classification Tree Models for Predicting Cancer Status
… assay for ovarian, breast, endometrial, and lung cancer. To evaluate the accuracy of early stage detection, logistic regression (with forward selection) and classification tree models were applied as statistical methods. Furthermore, complexity parameters and the number of bootstrap …
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Liver Injury in HIV-positive Patients on Antituberculosis and/or Antiretroviral Therapy – Assessing Causality
… (DILI) due to antituberculosis therapy (ATT) and/or antiretroviral therapy (ART). Methods Cases were drawn from a prospective registry of hospitalised adults with suspected DILI due to ATT and/or ART in Cape Town, South Africa. Participants had to fulfil American Thoracic Society criteria for …
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Network meta-analysis with rare events and misclassified response.
… such as misclassification, measurement error, and unmeasured confounding can lead to substantially biased estimators. It is strongly recommended that epidemiologists not only acknowledge these sorts of errors in data but also incorporate sensitivity analyses into part of the total data …
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Digital amplification for pathogen detection in bloodstream infections from whole blood
Sensitive and specific detection of bacteria is essential for control and treatment of bloodstream infections. Sepsis, a diagnostic challenge of blood stream infections, causes thousands of deaths each year. The gold standard for detection and identification of microorganisms is blood culture, …
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Does a verbal autopsy narrative provide accurate information about treatment default for people who have died from HIV/AIDS?
… (2017/18) project utilized the WHO 2016 standard VA questionnaire, which included both structured questions and an open narrative from the next of kin to describe the events surrounding deaths. An unexpected finding was the significant number of HIV/AIDS-related deaths mentioning treatment …
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