Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"senolytic"”.
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Cellular Senescence in Non-Small Cell Lung Cancer: from mechanisms to therapeutic opportunities
… preferentially target senescent cells, known as senolytics, have been successful in preventing and even reversing senescence-driven detrimental effects in multiple pathological processes. However, their suboptimal specificity and toxicities hamper their clinical translation. Therefore, the …
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Premature vascular senescence during diabetic retinopathy
… including the retinal vasculature. <br/><br/>Senolytic drugs are investigated as a therapeutic approach for elimination of senescent HRMECs. Navitoclax was found to be an effective senolytic for HRMECs<i> in vitro</i>.
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Investigating the impact of ageing on the tumour microenvironment and its crosstalk with malignant cells in pancreatic cancer
… abundance of senescent cells, suggesting that senolytic therapy could be a potential therapeutic strategy against aged PDAC. Using a recently developed natural language processing and graph network-based machine learning approach, I also demonstrated that aged mouse models of PDAC better …
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Targeting epithelial senescence to augment renal repair
… show that depletion of senescent cells with a senolytic drug attenuates renal fibrosis in a murine model of reversible ureteric obstruction. I perform the first characterisation in vivo of the post injury renal epithelial senescent transcriptome at a single-cell resolution, identifying multiple …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… <em>SPUD</em> depletion in combination with the senolytic drug navitoclax significantly reduces the number of surviving senescent cancer cells, suggesting that <em>SPUD</em> depletion in combination with DNA damaging/senolytic therapy might be a potential approach to mitigate the effects of …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… a unique vulnerability for cetuximab as a senolytic agent. Combination therapy reduced EGFR signaling and induced macrophage-mediated antibody-dependent cellular cytotoxicity, thereby increasing the anti-tumor therapeutic response of OncoD-0J1 as a monotherapy.</p>
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Investigating senescence and senescence-escape in cancer cells
… that targeting senescent cancer cells with a senolytic drug and a DPP4 inhibitor resulted in a synergistic effect in MCF-7 cells, by decreasing the viability of senescent cells and reducing the number of senescence-escaped cells. Although further research should be conducted, our results and …
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Role of microglial senescence in central nervous system injury and regeneration
… functional experiment whereby I used a senolytic cocktail to kill senescent cells in the LPC model and examined how this impacted remyelination efficiency. Preliminary results indicate that the senescent cells may not be important for efficient remyelination to take place. Further work …
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Indocyanine Green J-aggregate Nanoparticles for Detection of Senescent Cells
… has expanded and the most promising senolytic drugs have been prioritized to early phase clinical trials. Despite treatments showing promising translational results, there is still a lack of tools and techniques to detect, identify and longitudinally monitor senescent cells in *in …
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Developing a Senomorphic Treatment Strategy in Osteoarthritis
… the senescence-associated phenotypes (SASPs), senolytics for eliminating senescent cells, and senomorphics for modifying the senescence phenotype. In fact, a senolytic, UBX0101, showed a protective effect for post-traumatic OA (PTOA) development in mouse models by reducing both OA histological …