Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"senescent cells"”.
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Investigating dysregulation in protein quality control mechanisms in senescent cells
… cell-states (proliferating, quiescent, and senescent) between two cell lines, primary human fetal fibroblast IMR-90s, and transformed carcinoma epithelial A549s, following proteotoxic stress. Our findings reveal a generally highly-conserved stress response to proteotoxic insult between all …
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Indocyanine Green J-aggregate Nanoparticles for Detection of Senescent Cells
… (SASP). Upon persistent damage or during aging, senescent cells accumulate in tissues and organs, partially due to an inefficient clearance by the immune system. The presence of senescent cells has been actively implicated in multiple pathological manifestations and chronic disorders including, …
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Targeting epithelial senescence to augment renal repair
… fibrosis and resulting organ impairment. Senescent cells accumulate in multiple organs with increasing age and with disease and are implicated in numerous disease processes, however the mechanism underlying this remains incompletely understood. The elderly and those with chronic kidney …
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Quantitative proteomic analysis of cellular senescence: from systems biology to targeted signaling pathways
… is a hallmark of cancer. However, in “normal” cells oncogene activation does not lead to transformation, but instead provokes cellular senescence. One characteristic feature of the oncogene induced senescence phenotypes involves formation of a unique type of chromatin, known as senescence …
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B-RafV600E에 의한 갑상샘 발암과정에서 Thyroid stimulating hormone (TSH) 의 역할연구
… Induces OIS in Primary Thyrocytes. 11 2. Cancer Cells in B-RafV600E PTC Tissues Escape from OIS. 14 3. TSH Increases DUSP6 Expression through Regulation of ROS Generation. 20 4. TSH Signaling Inhibits B-RafV600E–Induced Senescence through DUSP6. 28 5. Ras/AKT/c-Myc Signaling Is Reactivated …
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Cellular Senescence in Non-Small Cell Lung Cancer: from mechanisms to therapeutic opportunities
… a powerful tumour-suppressive mechanism whereby cells stably enter a cell-cycle arrest in response to oncogenic stress. However, the accumulation of senescent cells can alter the tumour microenvironment through a strong paracrine secretion of factors that can lead to detrimental and …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… it is a process of permanent growth arrest when cells lose ability to reactivate cell division cycle. One of the common molecular features of senescent cells is the failure of phospho-extracellular signal-regulated protein kinase 1/2 (pErk1/2) translocation to nuclei in response to growth factor …
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Senescence and the Innate Immune System
… prevents deoxyribonucleic acid (DNA) damaged cells undergoing proliferation, protecting against malignancy but at the expense of senescent cell accumulation. Since the proportion of senescent hepatocytes in man correlates closely with liver injury, fibrosis stage and mortality, prevention of …
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Functional Identification of MicroRNAs Counteracting Cellular Senescence
… linked to organismal ageing, and clearance of senescent cells has been shown to revert aspects of the ageing phenotype. We sought to identify miRNAs able to counteract replicative senescence at the cellular level, and investigate their effect in vivo. A library of 879 human miRNAs mimics was …
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Identifying Endogenous Drivers of Chronic Disease Using Novel Computational Methods
… dysregulated in aging and inflammatory disease. Senescent cells accumulate in tissues with age and release a potent mix of inflammatory signals into their surrounding milieu. TEs are diverse and abundant mobile elements within the genome that remain mostly dormant under normal conditions. TEs …
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Novel Proteases That Regulate Interleukin-1 Alpha Activity During Inflammation And Senescence
… (SASP), which drives the deleterious effects of senescent cells in multiple age-related diseases. Therefore, therapeutically targeting caspase-5 may be of interest for pathologies mediated by the non-canonical inflammasome and/or senescent cells. Finally we find that rs17561, a common IL1A …
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Investigating the role of microglial senescence in central nervous system injury and regeneration
… alterations and a specific secretory profile. Senescent cells accumulate in tissue with age and are implicated in neurodegenerative diseases such as Alzheimer’s disease (AD) and multiple sclerosis (MS). I asked whether cellular senescence may play a role in the ability of microglia to regulate …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… (HCC), is associated with the accumulation of senescent cells within the liver. Senescence is an acutely tumour-suppressive, but chronically pro-tumorigenic stress-responsive cell pathway. Senescent cells signal to immunocytes through a complex secretome, to trigger their own CD4+ T-cell …
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Exploring Beta Cell NADPH production using Organelle-targeted Apollo-NADP+ Sensors
A major function of beta cells is the production and secretion of insulin to maintain glucose homeostasis. Loss of this function is directly linked to progression of diabetes. The loss of beta cell function is exacerbated by cellular senescence associated with natural aging. Senescence impacts …
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Regulation and inhibition of pro-tumorigenic microenvironments
… Indeed, seminal work has shown that tumorigenic cells unable to grow in xenografts can form tumors when supportive stromal cells are present. Work by many laboratories has demonstrated that a wide variety of cells including endothelial cells, immune cells, the extracellular matrix and fibroblasts …
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Biological response to 8-oxoguanine base released during DNA base excision repair
… oxidative DNA damage still accumulates in the cells of organismal tissues. 8-oxo-7,8-dihydroguanine (8-oxo-Gua) is a compound occurring in cells as a major oxidative lesion due to guanine’s susceptibility to oxidation. A base excision repair pathway initiated by 8-oxoguanine DNA glycosylase …
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The role of High Mobility Group A1 protein in transcriptional regulation of cellular senescence
… as oncogenic stress. The chromatin structure of senescent cells changes dramatically, exemplified by the formation of senescence-associated heterochromatic foci (SAHF). Moreover, senescent cells secrete a series of functional molecules, which are collectively called senescence-associated …
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Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
Proliferation of normal diploid cells is arrested irreversibly after a certain number of divisions, called replicative senescence, which is paragon of the general process of cellular senescence. Once senescent, cells continue to function metabolically, but will not respond to mitogens. Decreased …
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