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Showing 1 to 3 of 3 for “"senescence-like growth arrest"”.
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
Cellular senescence is an end point of a signal transduction programme leading to irreversible cell cycle arresst accompanied by characteristic alterations to cell morphology, biochemical properties and gene expression profile. This phenotype can be triggered by a variety of stimuli including …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… population doubling, which is termed replicative senescence. Although the free radical theory has long been implicated in the senescence, recent studies have emphasized mitochondrial DNA hypothesis because mitochondria is the major ROS generator in addition to its high vulnerability to oxidative …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
A senescence-like growth arrest succeeded by rapid recovery of proliferative capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell …