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Showing 1 to 20 of 471 for “"senescence"”.
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Investigating senescence and senescence-escape in cancer cells
Despite the general concept that therapy-induced senescence (TIS) has a tumour-suppressive role, the presence of senescent tumour cells and the ability of cancer cells to escape from senescence could potentially lead to therapy resistance and tumour recurrence. While a wide range of …
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Senescence of Native Perennial Warm Season Grasses Senescence Associated Switchgrass Transcriptome
<p>Senescence of perennial crops enable continuous harvests after one sowing event. Perennials senesce at adapted rates of their native environments; however, early senescencing crops do not maximize the growing season as nutrient reallocation takes precedence. Chlorophyll degradation and nitrogen …
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Nucleolar dynamics in cellular senescence
… dynamic of nucleolar area triggered by different senescence inducers remains elusive. Besides, gene expression associated with enlarged nucleoli is not well understood. Here, I show nucleolar dynamics in different types of cellular senescence including oncogene-induced senescence (OIS), secondary …
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Respiratory Senescence in Corn Shoots
Made available in DSpace on 2014-12-10T17:12:36Z (GMT). No. of bitstreams: 1 6812144.pdf: 3324052 bytes, checksum: 9a68603cc6930acd31c45f9b019f3ee4 (MD5) Previous issue date: 1968
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Premature vascular senescence during diabetic retinopathy
Cellular senescence is the permanent state of growth arrest with significant phenotypic changes including the senescence-associated secretory phenotype (SASP) and triggered by mechanisms such as telomere shortening and DNA damage. Diabetes is associated with endothelial dysfunction, which is …
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Senescence and the Innate Immune System
Cellular senescence prevents deoxyribonucleic acid (DNA) damaged cells undergoing proliferation, protecting against malignancy but at the expense of senescent cell accumulation. Since the proportion of senescent hepatocytes in man correlates closely with liver injury, fibrosis stage and mortality, …
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The role of Biophotons in cellular senescence.
Senescence is the irreversible arrest of cell proliferation. While serving as a natural barrier against mutation progression, senescence's metabolic activity and elevated ROS levels can pose significant health risks. Concurrently, cellular metabolic processes, including mitochondrial respiration, …
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Pathway Profiling Of Replicative And Induced Senescence
<p>Senescence is a permanent withdrawal from cell cycle that occurs naturally in cells in response to the shortening of telomeres. This natural "clock" serves to limit the number of cell divisions and therefore protects the cell from potentially carcinogenic mutations. However, senescence also …
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Functional Identification of MicroRNAs Counteracting Cellular Senescence
Cellular senescence is a process closely linked to organismal ageing, and clearance of senescent cells has been shown to revert aspects of the ageing phenotype. We sought to identify miRNAs able to counteract replicative senescence at the cellular level, and investigate their effect in vivo. A …
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Targeting epithelial senescence to augment renal repair
Effective renal repair following injury is essential for maintaining normal kidney function and is vital to the health of millions of patients every year. Maladaptive repair occurs when kidneys fail to return to normal levels of function following an injury and have excessive fibrosis and resulting …
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Creg1 And Its Enhancement Of P16ink4a-Induced Senescence
<p>Bypassing cellular senescence, an irreversible growth arrest of cells that is activated in normal cells to become immortal is one of the prerequisites for carcinogenesis. Cellular senescence can be triggered by shortening of telomeres and certain cellular stresses. Using spontaneously …
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T-lymphocyte senescence and hepatitis C virus infection
Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma. The degree of fibrosis progression and treatment-related outcomes are critically dependent on the age of the infected individual. Progressive ageing is associated with a decline in the efficacy of …
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Cell senescence and aging in carcinogenesis and liver repopulation
… exposure to RS is a powerful inducer of cell senescence in hepatocytes in vivo. As reported in the preceding section of this report, several markers of cell senescence were expressed by RS-exposed hepatocytes, including senescence-associated β-galactosidase (SA-β-gal), cell hypertrophy, a …
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Storage Proteins in Apple Trees (Woody Plant, Nitrogen, Senescence)
This study was undertaken to elucidate into the mode of accumulation and subsequent degradation of storage proteins in apple trees. Protein isolation, characterization, and proteolytic enzyme study were involved.
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A Study of Clonal Senescence in A Ciliated Protozoan
Made available in DSpace on 2014-12-11T22:22:16Z (GMT). No. of bitstreams: 1 7212112.pdf: 2401718 bytes, checksum: bb7621b6758883d1f101653874d9339e (MD5) Previous issue date: 1971
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… of senescent cells within the liver. Senescence is an acutely tumour-suppressive, but chronically pro-tumorigenic stress-responsive cell pathway. Senescent cells signal to immunocytes through a complex secretome, to trigger their own CD4+ T-cell dependent destruction, termed senescence …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
Cellular senescence plays an important role in biological processes such as development, aging and tumorigenesis, and it is a process of permanent growth arrest when cells lose ability to reactivate cell division cycle. One of the common molecular features of senescent cells is the failure of …
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The Role of the Stress Response Gene Gadd45b in Senescence
… stress. However, the role of Gadd45b in senescence remained unclear. Here, we show for the first time that primary mouse embryo fibroblasts (MEFs) from Gadd45b null mice proliferate slowly; accumulate increased levels of DNA damage, and senesce prematurely. Notably, this is in contrast …
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P16/INK4a controls the morphology program associated with cellular senescence
Background: Cellular senescence is a state which normal cells enter following an extensive period of proliferation or upon exposure to various kinds of stress. The senescence program involves G1 arrest accompanied by dramatic changes in cell function and morphology. The molecular mechanisms that …
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