Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"semi-synthetic"”.
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Multifunctionalization of Proteins: Strategies for Combining Semi-Synthetic and Bioorthogonal Techniques
… use AaT to install a unique N-terminal protein semi-synthesis ligation site. Additionally, Amber codon suppression is used to site-specifically incorporate Uaa side chains with click-chemistry handles, intrinsic fluorophores, and photocrosslinkers into proteins. Click-chemistry is used with …
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Fouling of Aluminum Oxide Microfiltration Membranes by Semi-Synthetic Metal Working Fluids
… were validated through the reformulation of a semi-synthetic MWF designed to have greater microemulsion stability. It was experimentally verified that the new fluid did not see significant aggregation. Accordingly this fluid did not show evidence of significant flux decline. Functionality tests …
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Spatial outbreak detection analysis tool : a system to create sets of semi-synthetic geo-spatial clusters
… as parameters at program execution. Sample semi-synthetic datasets from the cluster creation tool were then used to validate a popular spatial outbreak detection algorithm, the M-Statistic.
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Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B.
… weak in terms of their activity, each semi-synthetic agent also displayed notable synergistic action when used in conjunction with polymyxin B against S. aureus, C. violaceum, E. coli and PS. aeruginosa. In these cases, they demonstrated FICs from less than 0.093 to 2. The compounds …
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Investigation of Nigerian Ethno-medicinal Plants as Potential Sources of Cytotoxic and Anti-plasmodial Compounds. Biological activity of Vitellaria paradoxa, Cyperus articulatus, Securidaca longepedunculata and semi-synthetic halogenated analogues of cryptolepine isolated from Cryptolepis sanguinolenta
… of the thesis, novel cryptolepine analogues were semi-synthesized using environmentally friendly methods and evaluated for cytotoxic, anti-plasmodial and anti-trypanosomal activity. The compounds were found to be highly cytotoxic in cancer cell lines with the ability to overcome drug resistant …
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Protein Semi-Synthesis in Vivo
… function. This thesis describes the ligation of synthetic molecules to target proteins in an intracellular environment, and the use of semi-synthetic proteins for whole animal studies. In the first approach a cellular protein is genetically tagged with one half of a split-intein. The …
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Messa a punto di procedure per la semi-sintesi di composti ad attività antitumorale partendo da prodotti naturali. Studi di struttura-attività
… modified compounds, which have been prepared via synthetic or semi-synthetic routes. To the best of our knowledge, a very limited number of C, D, or E ring modified analogues of CPT have been reported; moreover, the few derivatives known from the literature showed a reduced or no biological …
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Synthetic Studies in the Didemnin Series
Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl …
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NOVEL SYNTHETIC PROCESSES FOR THE INDUSTRIAL PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
The project deals with the development of new synthetic processes for the industrial preparation of two emerging active pharmaceutical ingredients (API). Specifically, the process for the preparation of a new paclitaxel prodrug, namely octadecanedioc acid-paclitaxel, was defined. This paclitaxel …
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Extraction and Characterization of Xylopic Acid from Xylopia aethiopica
… products. It has also led to the development of semi-synthetic drugs and pharmacologically-active compounds. Essential oils from different parts of <em>Xylopia aethiopica,</em> a plant of Africa, showed various degrees of anti bacterial activity. The activity has been attributed to the presence …
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Exploring the Roles of Heme Type and Histidine -Tyrosine Cross -Link in Heme-Copper Oxidases Using a Myoglobin Model
… into the CuBMb model in this study: (1) synthetic heme cofactors are used to replace the natural one of the protein, resulting in ∼20 fold inhibition of the side reaction; (2) a novel semi-synthetic system (Expressed Protein Ligation) is also established that may introduce new …
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Pleuromutilin and its Application Towards Bidentate Antibiotics: Triazoles, Linker Chemistry, and Serendipitous Discoveries
… in microbes develop and propagate. The semi-synthetic derivatization of natural product antibiotics has provided many of our treatments, but new treatments are a constant necessity. The pleuromutilin antibiotics constitute a class of diterpenoid, ribosome-inhibiting antibiotics. …
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Occurrence, characterisation and variations of microplastics and cellulose fibres in the Scottish Atlantic coastal marine environment
… (rainfall, wind, tourism). Investigations into semi-synthetic and<br/>natural fibres found that cellulose fibres were mostly natural even though semi-synthetic fibres were also present. The<br/>cellulose fibres dominated the particles found in mussels (60%), seawater (53%)<br/>and in the …
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The design of a combustion test facility for synthetic jet fuel research
… commercial producer of approved and certified semi-synthetic and fully synthetic jet fuel. The project described in this report formed part of one of these research areas, which pertained to ignition and combustion stability in gas turbines and the role played by various fuel attributes and …
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Investigating the chemical space and metabolic bioactivation of natural products and cross-reactivity of chemical inhibitors in CYP450 phenotyping
… point for the discovery and development of novel semi-synthetic or wholly synthetic drugs. In Africa, and many other parts of the world, natural products in the form of herbal remedies are still used as primary therapeutic interventions by populations far removed from conventional healthcare …
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… to synthesize novel analogs not attainable by semi-synthetic methods. The region of the molecule we wish to focus on is the furan ring. Our routes to Salvinorin A were designed to allow for changes to be made to the section of the molecule where the furan is ring late in the synthesis. Part II: …
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PRADA-TF: Privacy-Diversity-Aware Online Team Formation
… Netscience) with 1,590 scientists, used the semi-synthetic datasets to construct a trust network based on a belief model called Subjective Logic, and identified trustworthy users as candidate team members. Via our extensive simulation experiments, we compared the seven different TF schemes, …
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The use of mineral oil as a trapping agent for volatiles produced by Ceratocystis moniliformis (Hedg.)
Ceratocystis moniliformis grows well in a semi-synthetic liquid medium containing 30:1 glucose:yeast extract, vitamins, and minerals. At 25°C and 100 rpm on a rotary shaker, the culture grows and produces many pleasing and potentially useful fruity aroma-bearing compounds. A sensory evaluation …
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Statistical Evaluation of Deep Learning for Event Detection in Time Series: Quantifying Uncertainty, Efficiency, and Adaptation with Applications to Seismic Data
… As part of this study, I contribute SeisTask, a semi-synthetic benchmark dataset with controlled, physically meaningful sources of shift for future study on adaptive learning approaches. The third study provides an empirical comparison of meta-learning and hierarchical Bayesian modeling and …
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