Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"self-tolerance"”.
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Drug design strategies for modulating immune activity for the treatment of autoimmune diseases and cancer
… body from foreign pathogens and damaged cells. Self-tolerance mechanisms exist to prevent the immune system from attacking normal cells. However, malfunctions in the self-tolerance mechanisms can result in the inability of the immune system of distinguishing self and non-self, cause damage to …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… to involve environmental factors that disrupt self-tolerance to myelin autoantigens but their identity and mode of action are unknown. This study reports that the epitope specificity of autoantibodies to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is …
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THE INNATE CYTOKINE IL-18 INHIBITS CNS AUTOIMMUNITY THROUGH PREFERENTIAL ACTIVATION OF PROTECTIVE CD8 T-CELLS
… immune activation is widely thought to challenge self-tolerance. IL-18 is an innate, inflammasome-activated cytokine and potent amplifier of T-cell activation. In excess, IL-18 is associated with certain autoinflammatory, but not autoimmune, diseases. We tested how excess IL-18 affected …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
… tumor growth, CNS immunosuppression, and self-tolerance.
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the molecular underpinnings underlying the development, suppressor function and stability of Tregs is …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… two known ligands, PD-L1 and PD-L2, to maintain self-tolerance. The PD-1-deficient proband had not only TB but also multi-organ autoimmunity and died of autoimmune pneumonitis at age 11 years. His older brother also had type 1 diabetes and died of pneumonitis of undocumented etiology at age 3 …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… sclerosis (MS) are believed to develop when self-tolerance mechanisms are failing, with a chronic destructive inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human counterparts; experimental autoimmune encephalomyelitis (EAE) – a model …
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BACH2 orchestrates thymic T cell differentiation and functional programming
… cell development and establishing immunological tolerance. It is tasked with maximising the number of foreign antigens which can be recognised by the T cell receptor (TCR) repertoire in order to protect from infection. Simultaneously, the thymus must ensure self-tolerance by pruning the …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
… of several nuclear antigens which might break self tolerance. Autoantibodies directed against the nuclear antigens will form large immune complexes (ICs) which are central in the immunopathogenesis of SLE. Through activation of the complement system, ICs mediate tissue destruction, and through …
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cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis
… of the immune system in response to a loss of tolerance. Early experiments showed that self-tolerance could be partially restored by oral inoculation with small amounts of insulin. Later experiments showed that insulin autoantigen induced immune tolerance could be greatly enhanced by linkage of …
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FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… ICOS signalling, can cause a breakdown of self-tolerance, thus leading to autoimmunity. Furthermore, ICOS has been linked to the function of Tregs. The aim of the present study was to investigate the association between the FOXP3 rs2294020, ICOS rs6726035 and ICOSL rs378299 SNPs and the …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
… to TCDD may also impair the establishment of self-tolerance, resulting in an increased risk of autoimmunity. For example, we observed that a single prenatal TCDD exposure given to non-autoimmune-prone high affinity aryl hydrocarbon receptor (AhR) C57BL/6 mice resulted in an immune …
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Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… and P30 to the mouse PAMP sequence to counteract self-tolerance, and the empty plasmid was used as a negative control (PcNeg). The plasmids were introduced into Salmonella typhimurium bacteria that were then converted into bacterial ghosts. C57BL/6J mice were orally immunized with the ghosts five …
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Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis
The breakdown of immunological self-tolerance manifests clinically as autoimmune diseases, such as Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS). Autologous haematopoietic stem cell transplantation (AHSCT) has received increasing attention in recent years as a …
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Novel markers for human T regulatory cells in healthy donors and cancer patients
… cells (Tregs) are essential for maintaining self-tolerance and preventing autoimmune diseases. However, FoxP3+ Tregs contribute to the progression of cancer and their levels expand in cancer patients compared to healthy donors. Tregs suppress tumour-specific immune responses by accumulating …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an …
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Ex Vivo Induction of Human Regulatory T Cells
… in the human immune system in the maintenance of self-tolerance and immune homeostasis. The dysregulation of Treg number and/or function plays a critical role in the pathogenesis of cancer, allergy and human autoimmune pathologies such as multiple sclerosis, psoriasis, rheumatoid arthritis and …
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
… cells are critical in the maintenance of self-tolerance, immune homeostasis and regulation of the immune system. Cytokine signalling is a dominant component of environmental signals which controls the function of Forkhead box P3 (Foxp3) regulatory T cells. This thesis addressed the …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
… satisfactory levels of sustained immunological tolerance remains to be accomplished. To restore self-tolerance requires delivery of sufficient amounts of autoantigen to stimulate regulatory T helper cells that function to survey the gut and induce tolerance to consumed antigens such as food. …
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Bone Marrow Derived Progenitor Cells and Their Contributions to the Thymic Stroma
… for the development and selection of a self-tolerant T cell repertoire. In paradox to its critical functions for the adaptive immune response, the thymus undergoes a profound age associated decline beginning in early adult life resulting in significant decline in T-cell function.Thymic …
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