Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"self-targeting"”.
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Precise and expansive genomic positioning for CRISPR edits
… has been fashioned from the natural DNA/RNA-targeting ability of certain CRISPR-associated (Cas) proteins and their guide RNA, which work together to recognize and defend against infectious genetic threats. This straight-forward RNA-programmed sequence recognition by CRISPR has facilitated …
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Cd56-Specific T Cells: Using Genetically Engineered T Cells to Redirect Specificity to A T Cell Expressed Antigen
… in that the T cells would be susceptible to self-targeting a.k.a. fratricide. However, we expand CD56-specific CAR<sup>+</sup> T cells that co-express the CD56 antigen. Since other CARs targeting T cell expressed antigens are hypothesized to be undergoing fratricide, such as the CD38-specific …
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Tax Policy, Housing Markets, and Redistribution
… with low consumption and lifetime income. Such "self-targeting" makes automatic transfers undesirable, as the social value of this information generally exceeds the social costs of the ordeals used to reveal it.
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Modulation of the CRISPR-Cas9 Immune Response
… to risk autoimmunity through the acquisition of self-targeting spacers. In type II-A CRISPR systems, Cas9 uses the guide RNA to cleave target DNA sequences in the genome of infecting phages, and the tracrRNA to bind the promoter of cas genes and repress their transcription. We previously isolated …
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Better safe than sorry: new CRISPR/Cas9 tools for improved genome engineering
… persistence into cells over time, we developed a Self-Limiting Cas9 circuitry for Enhanced Safety (SLiCES) which consists of an expression unit for SpCas9, a self-targeting sgRNA and a second sgRNA targeting a chosen genomic locus. This self-limiting circuit, by controlling Cas9 levels, results in …