Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"self-association"”.
-
Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
… micro- and nano-scale. However, clustering and self-association are not necessarily the same piece of information and may have very different effects on the cellular response, so mapping the preferential nanoscale distribution of the various self-association states is of particular interest to …
-
BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
… material that could be used to elucidate the self-association pattern and hetero-interactions mediated by these components within the pathway. SIKE full-length, SIKE 72 (residues 72-207), NAP 270 (residues 1-270) and NAP 255 (residues 1-255) expression constructs were completed and recombinant …
-
Design, Synthesis and Applications of Complementary Quadruply Hydrogen Bonding Modules: A. Redox Responsive Naphthyridine and Application in Polymers. B. Probing the Polymeric Environmental Effect on the Complexation of Strong Hydrogen Bonding Species
… By their design, exhibit high stability in self-association or hetero-complexation, enabling a high fidelity assembly.
-
Functional properties of galectin-3. Beyond the sugar binding.
… carbohydrate ligands can induce galectin-3 self-association that involves CRD to CRD binding. This “type-C” self-association engages more galectin-3 molecules than there are available glycan ligands and can explain certain biological events that require fast galectin-3 mobilization. In the …
-
The cross-linking mechanism of filamin A in the actin cytoskeleton
… domains of filamin are more flexible than the self-association region of the dimer. These findings dispute the initial claim that filamin is a rigid molecule. This thesis investigates the binding modality of filamin to actin. The structure of filamin bound to actin was compared to filamin in …
-
WDR5 Network Analysis Using Ensemble Approaches
… surface plasmon resonance (SPR) to calculate the association and dissociation rate constants. Furthermore, we used fluorescence polarization (FP) to calculate the equilibrium dissociation constants. After characterizing these PPIs under wild-type conditions we quantified the impact of key WDR5 …
-
Identification and Analysis of Germination-Active Proteins in Bacillus Spores
… domain was demonstrated to have strong self-association and may mediate self-association within the dormant spore. Additional genes that contribute to efficient initiation of spore germination in a GerA-dependent manner were identified via TnSeq. Chemical cross-linking of dormant spores …
-
Asssessing the Liquid-Liquid Phase Separation Abilities of Eyes Absent Protein
… strongly indicate that EYA2-TAD is capable of self-association in vitro.
-
Tale of two cultures: Hip-hop and schooling and the impact on African American identity and academic achievement
… about the storytelling aspects and notions of self association with hip hop? To what extent might African Americans experience hip hop as social resistance? How have urban youth associated with hip hop think and talk about the place of school in their lives, experiences with public schooling …
-
New routes to enantioenriched substances through small organic molecules
… This phenomenon when accompanied by substrate self-association impedes the complete recovery of the major enantiomer through formation of an inescapable racemate cage. A synthetic sequence for the asymmetric synthesis of bicyclo[3.2.0]heptanones and bicyclo[3.2.0]hept-3-en-6-ones through a …
-
NMR structural and functional studies of the mithochondrial outer membrane protein VDAC by Thomas J. Malia.
… means, evidence of a concentration dependent self-association of VDAC is also presented. Chemical cross-linking, analytical size exclusion chromatography, and NMR spectroscopic studies strongly support an equilibrium model for LDAO-purified VDAC between monomer and trimer.
-
Hydration and activity studies of bovine skeletal muscle proteins and wheat gliadins by nuclear magnetic resonance
… at high ionic strength (with 0.5 M NaCl). Myosin self-association in the form of tail-to-tail dimers was inferred from the NMR data in the absence of salt. At higher salt concentrations than 0.6 M NaCl, heptamer formation was inferred for myofibrillar proteins, whereas in the presence of 0.5 M …
-
Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention
… by which flavonoid antioxidants may prevent Aβ self-association and destabilize toxic aggregates, providing insight into the chemical features that give rise to this therapeutic effect.
-
Protein -Protein Interactions of Synucleins: Implications for Normal Function and Neurodegenerative Disease
… the fatty acid, arachidonate, accelerates AS self-association, a process that may be involved in Parkinson's disease. The final chapter presented here shows that arachidonate also interferes with alpha-synuclein's inhibition of PLD2.
-
Probing the conformational dynamics of amyloid oligomers in biologically relevant microenvironments
… in mediating oligomerization events, including self-association, cross-seeding and lipid interactions. This work provides a rationale for the future development of therapeutics to disrupt the formation of cytotoxic amyloid oligomers.
-
Yeast Ataxin-2 (Pbp1) Condensates Regulate TORC1 Activity and Autophagy in Response to Cellular Redox State
… or gel-like states in vitro and enables self-association of full-length Pbp1 into pelletable assemblies in vivo. Sequence analysis revealed that Pbp1 LC region contains an unusually high frequency of methionine residues (24 methionines in 150 a.a.) compared to the rest of the yeast …
-
The Relationship of Structure and Immunogenicity of the Bee-Venom Peptide Melittin
… "peptide-detergent" properties such as self-association and the ability to bind and oligomerize in cell membranes, and only peptides of a minimum size of 24 amino acids are immunogenic. Analogs of melittin that retain these properties elicit strong antibody responses; analogs that lack …
-
Structural studies of HIV-1 Vif and its SOCS-box domain
… in high salt concentration in order to prevent self-association. Comparison with previous studies on Vif expression and purification. This protocol enables one to obtain purified Vif from E. coli and opens the way to solve the structure by X-ray crystallography and extend our understanding on …
Page 1 of 3