Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 238 for “"self renewal"”.
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Extracellular Signalling and Stem Cell Self-Renewal
… Epi-derived mouse ES cells to exit self-renewal. Conversely, in human ES cells and postimplantation Epi-derived mouse epiblast stem cells, FGF signalling is instead required for pluripotency maintenance. It remains unclear how these divergent outcomes arise, especially as these cells …
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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
… regulator of homeostasis by balancing stem cell self-renewal, proliferation and differentiation processes. In skin, MYC induces the exit of epidermal stem cells from their niche, increases proliferation of progenitor cells and subsequently stimulates lineage specific differentiation into …
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Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
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REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
Reactive oxygen species (ROS) act as important signaling molecules required for fundamental biological processes such as stem cell maintenance. However, aberrant ROS levels lead to oxidative stress, which is highly associated with various human diseases such as cancer and aging. Here, I examined …
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The cell-secreted microenvironment : shaping embryonic stem cell self-renewal and differentiation
… pathways required to maintain stem cell self-renewal and to initiate an exit from the self-renewing state. In this thesis, we describe work showing that mouse embryonic stem cell (mESC)-secreted signals are required to maintain self-renewal, as cells enter a primed, epiblast-like state of …
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Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation.
… TAM. This low nuclear GATA2-ERT led to enhanced self-renewal of myeloid progenitors in vitro and was able to immortalize primary bone marrow (BM) cells into IL-3 dependent myeloid cell lines. Continuous GATA2-ERT expression was also required for the proliferation of these immortalized lines. Nmyc …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
<p>Hematopoietic stem cell (HSC) self-renewal, proliferation and differentiation are regulated by signaling through protein tyrosine kinases (PTK) such as c-kit, Flt-3 and Tie2. PTKs work in concert with receptor protein tyrosine phosphatases (PTPs) to maintain cellular equilibrium. The functions …
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Self-renewal pattern-associated genes and their role in adult stem cell functions
… this research was that the study of asymmetric self-renewal, a defining property of ASCs, might provide key clues to understanding ASC function and lead to discovery of novel molecular markers for ASCs. Fifty two self-renewal pattern associated (SRPA) genes were identified by cDNA microarray …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… spermatogenesis, must maintain a balance of both self-renewal and differentiation. Although several factors important for these processes have been identified, the fundamental mechanisms regulating SSC self-renewal and differentiation remain essentially unknown. The work presented here describes …
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Analysis of an epigenetic regulator in mouse embryonic stem cell self-renewal and differentiation
… study showed that Trx2 is redundant for ES cell self-renewal. Homozygous trx2 knockout ES cells did not exhibit cell cycle defects. However, loss of Trx2 resulted in reduced proliferation and increased apoptosis rates in trx2-/- ES cells. Due to the fact that differentiation requires an …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… of the regulatory networks that orchestrate TSC self-renewal and differentiation remains incomplete. In this project, I characterised an epigenetic modifier, KDM1B, for its role in TSC self-renewal and differentiation. I identified this factor as a putative novel regulator of trophoblast stem …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
… cells proliferate rapidly in culture, a minority self-renew and remain CD133+, while a majority differentiate and become CD133-. Therefore, new strategies to identify and grow immature UCBSCs are important. Since little is known about signally mechanisms regulating self-renewal and differentiation …
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Self-Renewal Requirements of Human Embryonic Stem Cells and Their Engraftment Potential in Mouse Blastocysts
<p>Human embryonic stem cells (hESCs) are a unique population of cells derived from a 6 day old human embryo that can be maintained indefinitely in vitro and have the ability to differentiate to all adult cell types. In addition to their potential for cell based therapies in the treatment of …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… well as gain of expression of S6K1 affects the self-renewal ability of HSCs. Interestingly, when we overexpressed S6K1, it also resulted in reduced self-renewal of HSCs. Next, we assessed the role of S6K1 in the propagation of acute myeloid leukemia (AML). The mixed-lineage leukemia (MLL) gene …
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Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells
… that exhibit stem cell-like properties (e.g. self-renewal). Previous reports have shown that soft 3D fibrin matrices promote self-renewal in TRCs by promoting histone 3 lysine residue 9 (H3K9) de-methylation and Sox2 expression [1]. However, the underlying mechanism(s) by which soft 3D fibrin …
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AKR1B8 IS A NOVEL MODULATOR OF CRYPTIC SELF-RENEWAL AND SUSCEPTIBILITY TO COLITIS AND ASSOCIATED CANCER
… maturation, disrupting dynamic homeostasis of self-renewal. AKR1B8 deficient mice were highly susceptible to colitis induced by dextran sulfate sodium at a lower dose (2%) and demonstrated severe liquid diarrhea and gross bleeding. Histopathologically, AKR1B8 -/- mucosa had drastic inflammatory …
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
… neuroblast divides asymmetrically to produce a self-renewing neuroblast and a ganglion mother cell that is committed to differentiation. The balance between neuroblast self-renewal and differentiation is tightly controlled to ensure the proper development of the central nervous system. In this …
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PTEN regulates the BMI1-mediated self-renewal of long-term hematopoietic stem cells in developmental and stress conditions
In the hematopoietic system, self-renewing long-term hematopoietic stem cells (LT-HSCs) maintain stem cell pools and differentiate into hematopoietic progeny. In addition to its critical role in the daily production of blood cells, LT-HSCs are able to resist the threats posed by various types of …
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Roles of Nanog, a transcription factor for self-renewal of embryonic stem cells, in prostate tumor initiation and chemoresistance
… involved in the acquisition of unlimited self-renewal and tumor initiation by cancer stem cells is unknown. Nanog, along with Oct3/4 and Sox-2, constitute the core transcriptional circuitry for the maintenance of stemness in embryonic stem cells. Herein we report that Nanog expression was …
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