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Showing 1 to 20 of 26 for “"selectivity index"”.
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Evaluation of a Power Plant Reservoir As A Holding Area For Paddlefish Brood Stock
… Cyclopoid copepods had the highest mean selectivity index and Diaptomus spp. the lowest mean selectivity index. Mean selectivity values of other food items were all near 0, indicating that paddlefish had no preference for or against them.</p>
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Structure-aided design of inhibitors of Mycobacterium tuberculosis thimydilate kinase
… combining a low Ki-value (40 mM) with a high selectivity index for the tuberculosis enzyme (Ki TMPKh/ Ki TMPKmt = 26) emerged as the most promising lead for further optimisation. Attempts were made to combine these favourable 3'-substitution patterns with 2'-halogen substituents (6.9-6.14). …
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Food Selectivity of the Black Bullhead (Ictalurus melas, Rafinesque) in Lake Poinsett, South Dakota
… organisms consumed in summer and fall. Food selectivity of young-of-the-year and adult bullheads for seven major species of zooplankton and adults for five categories of benthos was determined using the index described by Ivlev (1961). Adults and young-of-the-year positively selected limnetic …
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… these neglected tropical diseases, and the high selectivity index of actinoallolide A makes it a promising drug candidate. Enabled by the highly stereocontrolled aldol reactions of three chiral ketone building blocks, an efficient fi rst total synthesis of the potent antitrypanosomal macrolide …
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Semisynthetic Development of Blasticidin S as an Antibiotic Lead and Development of Other Anti-Infectives
… gram-positive bacteria and an increase in selectivity index for pathogenic bacteria over human cells. Our best derivatives increased the antibacterial activity up to 32-fold versus blasticidin S, resulting in MIC's as low as 4 g/mL. The selectivity indices for our derivatives likewise …
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Testing the forage preference of the American pika (Ochotona princeps) for use in connectivity corridors in the Washington Cascades
… of these trials were analyzed using the Jacobs’’ selectivity index, Hotelling’s T<sup>2</sup> tests, and one-sample t-tests. Douglas fir (<em>Pseudotsuga menziesii</em>), Sitka alder (<em>Alnus viridis</em>), willow (<em>Salix spp.</em>), and black cottonwood (<em>Populus balsamifera …
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Antimicrobial Polymers as Adjuvants/Synergists of Antibiotics to Combat Multidrug-Resistant Bacteria
… in these combination systems, the therapeutic index (also known as selectivity index), which is an indicator of an antimicrobial system to preferentially target bacteria over mammalian cells, is higher than the standalone agents. Furthermore, in this thesis, other selected antimicrobial …
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Determinants of wet season landscape and forage selectivity by cattle on farm Kiamsab West 364, central Namibia
… the determinants of forage and landscape selectivity by cattle during the wet season at Farm Kiamsab West, Central Namibia. Transects were demarcated on crests (n = 12, 72 plots) and slopes (n = 13, 78 plots) based on where cattle had been observed grazing, grazing signs, and …
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Neurons in Cat Primary Visual Cortex cluster by degree of tuning but not by absolute spatial phase or temporal response phase
… spatial frequency tuning width and direction selectivity index all showed significant clustering. Absolute spatial phase and temporal response phase, however, showed no clustering. We also present an algorithm that improves the performance of spike-sorting algorithms, for use in analyzing …
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The physico-chemical and biological analysis of microbial biosurfactants (BSs) for applications towards cancer therapies, wound healing dressings and drug delivery
… cells, additionally, all BSs had higher selectivity index than doxorubicin (DOX) and therefore have potential application as an anticancer agents. Novel, durable, porous, composite advanced wound dressings incorporating free BSs and niosome encapsulated BSs were developed for potential …
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Studies on the synergic activity of a three-drug cocktail active against cisplatin-resistant human leukemia and carcinoma cells
… (2) determining the potential degree of selectivity of the most synergic drug combinations. Methods. Most studies were focused on the most potent Cu(II)Phen compound (C0), lead of the cupper-phen complex series. Wild type and CDDP-resistant human T-leukemia CEM cells, wild type and …
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Development and in vivo Analysis of Inhaled Clofazimine for the Treatment of Pulmonary Tuberculosis
… efficacy compared to unprocessed CFZ and a selectivity index of greater than 2000, indicative of its safety. In vivo analysis of CFZ DPPC in BALB/c mice using a validated dosing chamber revealed an inhaled CFZ concentration of about 16.79 µg/g of wet lung suggesting that CFZ DPPC particles …
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Designing Direct and Indirect Factor Xa Inhibitors
… design direct FXa inhibitors that possess high selectivity and are potentially orally bioavailable. Structurally, the designed direct FXa inhibitors are neutral THIQ dicarboxamides. THIQ dicarboxamide is a privileged structure with a semi–rigid character, a structural feature that potentially …
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Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
… to look further into the study of N,C-acylation selectivity for the ambidentate amino-pyrone moiety, whose reactivity is poorly known. Regioselectivity was investigated under different conditions (organic bases, solvent, acylating agent), also for an enamino-ester taken as a model compound. …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… cells. BTC2 did not display considerable selectivity to breast cancer cells as the calculated IC50 value for the normal fibroblast cell line (FG0) was found to be 0.85μM and thus the selectivity index was less than 2 in both cell lines. Clonogenic assays were performed and BTC2 was shown …
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Functional genomic study and bioinformatic analysis on natural bioactive peptides
… examination exhibited a highly synergistic selectivity and low cytotoxicity on mammalian cells of these three peptides. In chapter 5, the sequence modification was employed in the BHK-bombinin by replacing the glutamic acid with lysine at the 23rdposition from amino terminus, which increased …
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Evaluation of Novel Carbamate Insecticides for Neurotoxicity to Non-Target Species
… control of malaria. Additionally, the low selectivity of malaria vector insecticides also presents a public health problem. The purpose of developing novel carbamate insecticides in our laboratory is to offer effective and selective insecticide options to achieve the ultimate goal of …
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A survey of plants used to treat livestock diseases in the Mnisi community, Mpumalanga, South Africa, and investigation of their antimicrobial activity
… of 0.205 mg/ml and 0.105 mg/ml respectively.The selectivity index was used to relate the cytotoxicity to the antimicrobial activity of the plant extracts. Most of the plant extracts had values below 10 against all the tested microbes, implying that the biological activity of the plant extracts …
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Biological activity of Sinularia notanda
… towards the U937 lymphoma cell line (selectivity index > 2). These responses are not unusual as cembrane diterpenoids with anti-cancer potential are increasingly being isolated from soft corals.
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Multi-target drug discovery against Staphylococcus aureus and Trypanosoma brucei infections
… IC50 values as low as 12 nM (5.5 ng/mL) and a selectivity index of ~300. In the investigation of ways of action, the best compound targeted the mitochondrial membrane potential, exhibiting stronger uncoupling effect and better cell growth inhibition activity compared with SQ109 In another …
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