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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 17 of 17 for “"selective vulnerability"”.

  1. Role of metabolic stress in the selective vulnerability of dopaminergic neurons

    Adetuyi, Oluwatosin2026

    wichita-thes

  2. Investigating modifiers that can regulate selective vulnerability in mouse models of spinal muscular atrophy

    Woschitz, VictoriaThe University of Edinburgh2023

    … spared until late stages of the disease. This selective vulnerability of MNs is a well-known pathological hallmark of SMA, however the underlying molecular mechanisms of it are yet unknown. The work contained within this thesis aims to investigate the basis of selective vulnerability, which …

    edinburgh Repository record

  3. Investigating Cell-Type-Specific Vulnerability in Mitochondrial Disease Using Stem Cell-Derived Neuronal Models

    Zarate Mendez, MarianaUniversity of Cambridge2025

    … yet the molecular and metabolic drivers of selective vulnerability in different neuronal subtypes remain poorly understood. In this thesis, I developed human stem cell-derived neuronal models for two nuclear-encoded mitochondrial disorders that impair mitochondrial DNA (mtDNA) replication …

    cambridge Repository record

  4. Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias

    Kadamangudi, Shrinath 1993-The University of Texas Medical Branch at Galveston2026

    … synaptic dysfunction, trans-synaptic spread, and selective vulnerability. Given that synapses form the neural basis of memory encoding, investigating whether and how tauO modulate synaptic pathophysiology may offer critical insights into the pathogenesis of human tauopathies. This dissertation is …

    utmb Repository record

  5. Distinct Populations of Layer 5B Pyramidal Neurons in the Primary Motor Cortex

    Moya, Maria V

    … its varied functions, but may also reveal how selective vulnerability is established in neurodegenerative diseases that affect the motor cortex, such as Amyotrophic Lateral Sclerosis (ALS). Despite being expressed in all cells of the body, mutations associated with ALS lead to specific loss of …

    rockefeller Repository record

  6. Intra-Regional Differences in Cerebellar Vulnerability of Spinocerebellar Ataxia Type 1 Mice

    Hamel, Katherine2023

    … yet whether these differences contribute to selective vulnerability in cerebellar disease remains an open question. Spinocerebellar Ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by an abnormal expansion of polyglutamine (polyQ) repeats in the ATAXIN1 (ATXN1) …

    umn Repository record

  7. Elucidating Astrocytic Diversity in Human Cerebral Organoids

    Wenger, LeaUniversity of Cambridge2023

    … strategies for neurodegenerative diseases and selective vulnerability.

    cambridge Repository record

  8. The role of apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosis

    Bigini, PaoloThe Open University2005

    … neuromuscular deficits that are related to a selective vulnerability of cervical spinal cord motor neurons have an early onset and progress rapidly.<br></br><br></br> In my project of thesis I first characterized apoptosis in primary cultures of motor neurons exposed to detrimental stimuli, …

    the-open-u Repository record

  9. Impact of N-Acetyl-L-Cysteine on the Pathology of Experimental Parkinson’s Disease in Vivo

    Nouraei, Negin2017

    … to the human condition, we collected evidence of selective vulnerability to alpha-synucleinopathy, as the septohippocampal projections were spared in our model. Notably, Lewy-like pathology in the hippocampus was statistically correlated with memory and olfactory deficits. Taken together, these …

    duquesne Repository record

  10. Lysosomes and Ribonucleoprotein Dynamics in Neurons

    Fernandopulle, MichaelUniversity of Cambridge2021

    … give rise to neuron-specific deficits. Given the selective vulnerability of neurons to lysosomal dysfunction, a better understanding of the unique functions of lysosomes in neurons is necessary. To gain deeper insight into the biochemistry of neuronal lysosomes, we developed methods to engineer …

    cambridge Repository record

  11. Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins

    Seamans, Katherine Webster2011

    … dysfunction and oxidative stress with selective vulnerability of dopaminergic neurons. Although most cases of Parkinson’s disease are sporadic, 5-10% of cases are caused by mutations in a single gene. Loss-of-function mutations in parkin and DJ-1 were the first to be linked to …

    utswmed Repository record

  12. Ribonomic Control During Global Brain Ischemia And Reperfusion

    Wang, Haihui2014

    … technology to look at the mechanism behind the selective delayed death of hippocampus CA1 neurons after transient global brain ischemia. The main findings are summarized:</p> <p>1. The main form of ELAV protein family member detected in CA1/CA3 in Hu protein immunoprecipitation and polysomes was …

    wayne-thes Repository record

  13. In vivo and in vitro approaches to characterising axon growth and metabolic alterations in Parkinson’s disease

    Travaglio, MarcoUniversity of Cambridge2022

    … cysteine metabolism to compensate for early and selective defects in mitochondrial respiration and ATP production (Chapter 3). To answer if we can recapitulate these changes in a human model, I then used human induced pluripotent stem cells (iPSCs). I differentiated human induced pluripotent stem …

    cambridge Repository record

  14. Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration

    Kwa, Jing EugeneUniversity of Cambridge2023

    … neurons. To date, a comprehensive survey of selective neuronal vulnerability has not yet been performed. With recent advances in single-cell and spatial transcriptomic approaches, our hypothesis can now be investigated in an unbiased fashion and at unprecedented resolution. The work in this …

    cambridge Repository record

  15. Defining and Controlling the Subtype Identity of Human Stem Cell-Derived Motor Neurons

    Croft, Gist Fralley2012

    … appropriate cellular phenotypes in vivo; second, selectively generate those cell types in vitro; and third, demonstrate that iPS cells retain similarly predictable and tractable cellular potential as ES cells. In the motor neuron degenerative disease Amyotrophic Lateral Sclerosis (ALS) spinal …

    columbia-diss Repository record

  16. Endoplasmic Reticulum Morphoregulation Modulates Ca2+- Driven Brain Cell Functions

    Crapart, CécileUniversity of Cambridge2025

    … morphogens causing motor neurone diseases. The selective vulnerability of long axons highlights the significance of their extensive ER tubule-containing periphery for neuronal health, but the underlying pathophysiological mechanisms are yet to be elucidated. Therefore, a comprehensive …

    cambridge Repository record

  17. Vulnerability of ex vivo α-motor nerve terminals to hypoxia-reperfusion injury.

    Baxter, Rebecca L.The University of Edinburgh2010

    … of this study was to further characterise this vulnerability by examining the response of mouse α-motor nerve terminals at the neuromuscular junction (NMJ) to hypoxia-reperfusion injury. To address this aim, a novel model system was generated in which ex vivo skeletal muscle preparations could …

    edinburgh Repository record