Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"selective serotonin reuptake inhibitors"”.
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The elderly, arginine vasopressin & selective serotonin reuptake inhibitors
The association between selective serotonin reuptake inhibitors (SSRis) and hyponatraemia has been well documented, the elderly appearing to be at greatest risk. An analysis of data of hyponatraemia in the elderly using SSRis from all published cases and from the Committee on Safety of Medicines …
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The Effects of Selective Serotonin Reuptake Inhibitors (SSRI) on Auditory Measures in Women
This study examined the relationship between selective serotonin reuptake inhibitor (SSRI) medication and auditory measures in clinically depressed women. Experimental subjects were tested in both a medicated and unmedicated condition. Experimental subjects were compared to a normal control group; …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
… been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake …
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Changes in dream frequency, vividness and intensity in subjects taking selective serotonin reuptake inhibitors
… and vividness are increased with the use of selective serotonin reuptake inhibitors (SSRJ's) commonly prescribed for depression and anxiety. In this study the effects ofSSRI use on dream frequency, intensity and vividness in psychiatric patients was examined through a comparision of the dream …
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The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects.
… was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. …
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A preliminary study on the effect of selective serotonin reuptake inhibitors on peripheral and lower brainstem auditory processing.
… control subjects and subjects prescribed with a selective serotonin reuptake inhibitor (SSRI) who were yet to take the drug and those currently taking an SSRI. Test measures used were pure tone averages (PTA), acoustic reflex thresholds, uncomfortable loudness levels (UCL), otoacoustic emissions, …
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An In Vitro Characterization of the Raphe Nucleus and the Effects of SSRIs on Synaptic Neurotransmission
… While these drugs rapidly inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, clinical efficacy can take several weeks. This phenomenon implies that antidepressants not only target neurotransmitter transporters, …
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Case study to evaluate effectiveness of a treatment approach for major depression
… treat this client), and interpersonal therapy. Selective serotonin reuptake inhibitors were found to be the most highly recommended class of medications for those suffering from Major Depressive Disorder. Those with moderate to severe depression should be given medication and psychotherapy, …
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An Examination of Affective Blunting in Rodents
… Disorder and other mood disorders, particularly selective-serotonin reuptake inhibitors. Affective blunting is a potential side effect of chronic SSRI treatment, which can be defined as a diminished response to pleasurable or unpleasant stimuli, and is indicated as a marked indifference towards …
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Efficacy and safety of serotonin reuptake inhibitors (SSRI) and serotonin noradrenaline reuptake inhibitors (SNRI) for children and adolescents with anxiety disorders: A systematic review and meta-analysis
Selective serotonin reuptake inhibitors (SSRIs) are considered to be the first-line pharmaco-logical treatment of anxiety disorders in children and adolescents. Selective serotonin noradrenaline reuptake inhibitors (SNRIs) have also been proven to be effective. This study conducts a systematic …
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… disorder (OCD), are often treated with selective serotonin reuptake inhibitors (SSRIs). SSRIs typically express many pharmacological effects through inhibiting serotonin (5-HT) transporters; however, due to delayed and inadequate treatment effects, other treatment methods should be …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… most commonly used drugs in PTSD treatment are selective serotonin reuptake inhibitors (SSRIs), though only about 50% of patients respond to this treatment. Previous work in our lab demonstrated the combination of chronic fluoxetine (FLX) and acute ketamine treatment decreased fear response in a …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
… can hinder a person's life and ability to work. Selective serotonin reuptake inhibitors are the current treatments for these disorders, which take 8-12 weeks to take effect and leave many patients without adequate treatment gains. Delayed treatment effects may be due to neuronal proliferation …
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Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
… is still held to be the prevailing theory as selective serotonin reuptake inhibitors being the most commonly prescribed anti-depressants. However, the incidence of depression is still rising with a vast amount of patients failing to respond to current treatments, and with this knowledge, …
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Network mechanisms underlying susceptibility to helplessness and response to the antidepressant fluoxetine
… frequently treated with antidepressants such as selective serotonin reuptake inhibitors (SSRI’s). However, there are individual differences in susceptibility to stress-induced psychopathologies and response to antidepressants. Therefore, there is a need to identify biologic factors that predict …
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The Effect of SSRIs on Adult Human Visual Cortex Plasticity. Do SSRIs Affect learning?
Background: Selective serotonin reuptake inhibitors (SSRIs) have been shown to enhance visual cortex plasticity in adult animals (Maya-Vetencourt, Sale et al. 2008). The aim of this study was to assess whether SSRIs increase visual cortex plasticity in humans. Methods: To test healthy visual …
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The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study
Background: Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet activity. However, previous evidence regarding the cardiovascular effects of these agents has been …
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ASSOCIATION BETWEEN CONCOMITANT USE OF BISPHOSPHONATES AND SEROTONIN REUPTAKE INHIBITORS AND INCREASED RISK OF OSTEOPOROTIC-RELATED FRACTURES: AMONG COMMUNITY-DWELLING POSTMENOPAUSAL WOMEN
… 65 years or older. Bisphosphonates (BPs) and selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) are commonly used medications to treat these conditions. Inhibitory effects of BPs on osteoclasts are responsible for the reduction in fracture …
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Pharmacological Characterization of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening
… States population diagnosed as of 2017. The selective serotonin reuptake inhibitors (SSRIs) have been the mainstay of pharmacotherapies for depression for the last 40 years. The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating …
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Computational Ligand-Based CNS Therapeutic Design: The Search for Novel-Scaffold Norepinephrine Transporter Inhibitors
… transduction through control of neurotransmitter reuptake in the synapse, and are therefore relevant to diseases including addiction, psychosis, anxiety and depression. MATs, specifically the serotonin transporter (SERT or 5-HTT), norepinephrine transporter (NET), and dopamine transporter (DAT), …
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