Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"selective serotonin reuptake inhibitor"”.
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
Background: Selective serotonin reuptake inhibitor (SSRI) antidepressants prevent serotonin (5-HT) uptake by the serotonin transporter (SERT). Since blood platelets express SERT, SSRIs may modify platelet function and the risk of cardiovascular disease. However, the beneficial or adverse effects of …
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Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis
Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… that a key effect of chronic treatment with a Selective Serotonin Reuptake Inhibitor (SSRI) is loss of somatodendritic 5-HT1A receptor-mediated autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this …
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A preliminary study on the effect of selective serotonin reuptake inhibitors on peripheral and lower brainstem auditory processing.
… control subjects and subjects prescribed with a selective serotonin reuptake inhibitor (SSRI) who were yet to take the drug and those currently taking an SSRI. Test measures used were pure tone averages (PTA), acoustic reflex thresholds, uncomfortable loudness levels (UCL), otoacoustic emissions, …
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The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects.
… was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. …
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The Effects of Selective Serotonin Reuptake Inhibitors (SSRI) on Auditory Measures in Women
This study examined the relationship between selective serotonin reuptake inhibitor (SSRI) medication and auditory measures in clinically depressed women. Experimental subjects were tested in both a medicated and unmedicated condition. Experimental subjects were compared to a normal control group; …
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FLUOXETINE AS A NOVEL TREATMENT TO ATTENUATE CISPLATIN-INDUCED COGNITIVE IMPAIRMENT
… impairment (CRCI). Fluoxetine (FLX) is a selective serotonin reuptake inhibitor widely used in patients with anxiety and mood disorders. Published studies report that FLX could sensitize cancer cells to chemotherapy treatment and assist in attenuating CRCI. The aim of this study was to …
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Who Gets Better and Why? Predicting the Development of a Working Alliance and its Subsequent Role in Pharmacotherapy for Social Anxiety Disorder
… SAD received 12 weeks of open treatment with the selective serotonin reuptake inhibitor paroxetine. Higher levels of depression predicted higher levels of social anxiety symptoms at the end of treatment and higher levels of submissive behavior and childhood emotional maltreatment predicted a …
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The effect of Escitalopram on tonic and phasic alertness in healthy volunteers
… evidence of functional involvement of serotonin (5-HT) in attentional processes, especially regarding vigilance and psychomotoric speed. As demonstrated by earlier studies the statements concerning the influence of 5-HT on attentional processes remains somewhat inconsistent. Therefore, …
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Neurodevelopmental and Behavioral Consequences of Serotonin System Disruption via Early Life Exposure to SSRI Antidepressants
Selective serotonin reuptake inhibitor (SSRI) antidepressants are widely prescribed to pregnant women suffering with depression, although the long-term impact of these medications on exposed offspring are poorly understood. Perinatal SSRI exposure alters human offspring's neurodevelopment and …
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Drug Treatments for Post-Traumatic Stress Disorder in a Mouse Model
… dissociative anesthetic, and fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), have shown promise in their ability to treat stress-related disorders. The aim of this study was to determine the efficacy of <em>R-S</em> ketamine and FLX, alone and in combination, in reducing the …
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Identification Of A Treatment-Resistant, Ketamine-Sensitive Genetic Line In The Chick Anxiety-Depression Model
… antidepressant imipramine (0-20 mg/kg), the selective serotonin reuptake inhibitor (SSRI) fluoxetine (0-10 mg/kg), the tetracyclic antidepressant maprotiline (0-10 mg/kg), the glutamate receptor antagonist ketamine (0-15 mg/kg), or vehicle (physiological saline) and placed individually inside …
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EMOTIONAL MODELS: UNCERTAINTY AND THE ETHICS OF ANIMAL EXPERIMENTATION IN NEUROSCIENCE
… citing the lack of major discoveries since the selective serotonin reuptake inhibitor (SSRI) boom of the 1990s. Drawing on eighteen months of ethnographic fieldwork with academic neuroscientists, postdoctoral students, laboratory technicians, and graduate students, this dissertation explores how …
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Serotonin and Threat: from Gene to Behaviour
… emotions associated with threat than others? As serotonin has been implicated as a key neuromodulator of emotion, the thesis addresses this question by adopting a multi-systems approach to investigate the link between serotonin and both threat-driven behaviour and trait anxiety with the common …
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Serotonergic modulation of response inhibition : a fMRI study
In animal and human studies, the neurotransmitter serotonin (5-HT) has been implicated in inhibitory control. Using functional magnetic response imaging (fMRI), the present study investigated the acute effects of pharmacological modulation in the serotonergic system on brain activations during …
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An In Vitro Characterization of the Raphe Nucleus and the Effects of SSRIs on Synaptic Neurotransmission
… While these drugs rapidly inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, clinical efficacy can take several weeks. This phenomenon implies that antidepressants not only target neurotransmitter transporters, …
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The Roles of Inflammation, Oxidative Stress, and Neurotransmitters in an Animal Model of Post-Traumatic Stress Disorder
… effects of the histone deacetylase inhibitor (HDACi) valproic acid (VA) on inflammation/oxidative stress and neurotransmitters. Finally, we employed the selective-serotonin reuptake inhibitor (SSRI) sertraline to ascertain why SSRIs have historically been ineffective in treating …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia and hyperactivity (5-HT syndrome). Conversely, the long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage to serotonergic nerve terminals. Monoamine transporter systems at …
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Neuropharmacological Mechanisms Underlying Incentive Salience and Stress
… elevated stress hormones and treatment with the selective serotonin reuptake inhibitor fluoxetine, a commonly used antidepressant, was investigated on incentive behavior in the NIH paradigm. We found that exogenous corticosterone exposure facilitated reduced approach behavior caused by exposure …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
… intemeurons.</p> <p>Studies have shown that serotonin (5-HT) neurons are capable of DA synthesis following exogenous L-dopa administration. In addition, striatal hyperinnervation by serotonergic dorsal raphe nucleus (DRN) axon terminals occurs following prolonged DA depletion. This …
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