Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"selective autophagy"”.
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Atg11 and Atg9 interaction in selective autophagy
<p>Selective autophagy, induced by cellular stresses, degrades/recycles a specific cargo. Ithelps prevent diseases like Parkinson’s, Huntington's, cancer, and bacterial infections. It involves the formation of an autophagosome, a double-membrane vesicle that takes the cargo to the vacuole/lysosome …
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The role of DAXX in the selective autophagy receptor SQSTM1/p62 phase condensation
Macroautophagy (‘autophagy’ hereafter) is a lysosome-dependent degradation system for intracellular protein quality control. Autophagy can selectively remove cargo materials, which is dependent on cargo receptors. SQSTM1/p62 (‘p62’ hereafter) is one of the best characterised receptors mediating the …
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The Discovery of p62-dependent Processing Bodies
The cellular degradation process autophagy can be a selective process during which, cellular <br/>components, such as excess proteins, can be marked for degradation by the post <br/>translational modification ubiquitination. Proteins that act as selective autophagy receptors <br/>can recognise the …
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Determining the Molecular Underpinnings of Iron Homeostasis in Human Cells
… involved in ferritinophagy, a form of selective autophagy that leads to the lysosomal degradation of ferritin. Extending prior work that identified key components supporting ferritinophagy, including the selective autophagy receptor protein NCOA4 and its cognate autophagosomal receptor …
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Autophagy in Zellweger Syndrome Spectrum Disorder and Cancer
Autophagy is a lysosomal degradation pathway that breaks down unwanted proteins and organelles from the cytoplasm to regenerate cellular building blocks. This process is constitutively active at low basal levels, and can be upregulated by stress stimuli to promote cellular homeostasis. In this …
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The Mechanism of Mammalian Pexophagy
… peroxisomal membrane are not known, and the key autophagy receptor which binds ubiquitin at the surface of the peroxisome is not known. In the first chapter of this thesis, I introduce the peroxisome and the key players in general autophagy, as well as in the selective autophagy of the …
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Understanding host factors controlling intracellular killing of Mycobacterium tuberculosis
… interactions between MTB and modulators of the selective autophagy signalling pathway during early infection; and demonstrated how a STAT-cytokine pathway regulates macrophage lipid metabolism to influence host susceptibility to mycobacterial infection. Collectively, my findings provide evidence …
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The Regulation of Cellular Iron Metabolism
… of the cargo receptor NCOA4, responsible for selective autophagy of the iron-storing protein ferritin, intracellular iron depletion and activation of the IRP2 response to promote iron uptake. SETD2 loss of function mutations occur in up to 28% of kidney cancers (ccRCCs). I go on to show that …
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Mechanisms of TRIM21-directed intracellular degradation
… coated with antibodies are degraded by selective autophagy following polyubiquitin deposition by TRIM21. Taken together, this work represents a clear advancement in understanding how TRIM21 targets substrates for proteolysis, and opens several new lines of inquiry into how the protein …
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Novel mechanisms of diastolic dysfunction in diabetes
… labs have identified that glycogen-selective autophagy (glycophagy) is a process of lysosomal glycogen degradation that may operate in the myocardium in parallel with conventional macro-protein autophagy, and involves selective molecular partners to tag glycogen cargo (STBD1) and to …
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THE INTERPLAY BETWEEN THE PROTEIN QUALITY CONTROL SYSTEM AND EXTRACELLULAR VESICLES IN THE DISPOSAL OF DISEASE-ASSOCIATED PROTEINS AND MIRNAS IN ALS AND FTD MODELS
… the ubiquitin proteasome system (UPS) and the autophagy). However, TDP-43 has been also found into extracellular vesicles (EVs), both large (LEVs) and small (SEVs), suggesting that EVs could cooperate with the PQC system for the disposal of TDP species. Moreover, TDP-43 is an RNA-binding …
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Specific Recognition of Atypical Ubiquitin Modifications
… In the second part, the UBDs of all selective autophagy receptors were screened for interesting interactions with Ub. None of the UBDs tested exhibited linkage-specific interaction with Ub, except for OPTN, which prefers Met1-linked chains. Moreover, because autophagy receptors can …