Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"selectin"”.
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The role of NK cells in selectin-dependent tumor suppression
Selectins are a small family of adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has demonstrated that, in the absence of selectins, human tumors transplanted …
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The effect of P-selectin pattern width on HL-60 cell rolling behavior
The effect of varying the width of P-selectin band patterns on the rolling behavior of HL- 60 myeloid cells along edges of the band patterns was studied. The P-selectin and polyethylene glycol (PEG) pattern was produced via microcontact printing using a polydimethylsiloxane (PDMS) stamp. HL-60 …
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Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)
We aim to develop novel protein antagonists of P-selectin adhesion as anti- inflammatory therapeutics. Blocking P-selectin adhesion is particularly attractive because this adhesion mediates leukocyte rolling which occurs early in the inflammatory cascade before extensive tissue damage caused by the …
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APPROACHES TO IDENTIFY SURFACE PROTEINS OF ANAPLASMA PHAGOCYTOPHILUM DENSE-CORED ORGANISMS AS ADHESINS TO HUMAN P-SELECTIN GLYCOPROTEIN LIGAND-1
… anaplasmosis. Sialyl Lewis x (sLex)-modified P-selectin glycoprotein ligand-1 (PSGL-1) is the confirmed receptor utilized by A. phagocytophilum to bind and invade human neutrophils and myeloid cell lines. As an obligate intracellular pathogen, the binding of A. phagocytophilum to a host cell …
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
… is mediated by interaction of endothelial E-selectin with its counter-receptor(s) expressed on breast cancer cells. This hypothesis was tested by using a variety of specialized biochemical techniques and tumor cell/endothelial cell adhesion assays. It was found that breast cancer cells …
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Expression of leukocyte-endothelial adhesion molecules during acute inflammation in the lung
… circulation, the leukocyte adhesion molecule, L-selectin, facilitates PMN adhesion to inflamed endothelium while CD11/CD18 is required for PMN emigration into extravascular tissues. An inducible endothelial ligand for CD18 is intercellular adhesion molecule-1 (ICAM-1). In the pulmonary …
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Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… molecules mediate this process, particularly, E-selectin and ICAM-1, which are inducible adhesion molecules. E-selectin is involved in the initial tethering and rolling steps of the adhesion cascade while ICAM-1 appears to be involved in the latter steps. We have hypothesized that in response to …
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Interaction between cell adhesion molecules and stress hormones following different intensities of cycling exercise in obese males.
… molecule 1(sVCAM-1), and soluble endothelial selectin (sE-selectin)] over 24 hours following different intensities of exercise in obese men. In a randomised, cross-over design, 15 physically inactive (physical activity < 2 days per week) obese (BMI > 30 kg/m²) men between the ages of 18-30 …
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Targeted Multistage Delivery of Nanoparticles to The Bone Marrow
… while decreasing exposure to normal tissues. E-selectin is constitutively expressed on the bone marrow vasculature, but almost absent in normal vessels, and therefore, E-selectin targeted drug delivery presents an ideal strategy for the delivery of therapeutic nanoparticles to the bone …
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… It was found that immunoneutralization of P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (CD162) abolished radiation-provoked leukocyte and platelet rolling in the colon. Moreover, inhibition of P-selectin and P-selectin glycoprotein ligand-1 also markedly decreased firm adhesion of …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… can activate endothelial cells to express P-selectin and CXC chemokine (MIP-2) and cause leukocyte adhesion in vitro in a glucocorticoid-sensitive manner. Interestingly, chemokines, both MIP-Ialpha, MCP-I and MIP-2, KC, were found to provoke a dose-dependent increase in P-selectin-dependent …
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Effect of Monounsaturated Fat Rich Almonds on Hemostatic and Inflammatory Factors in Healthy Adults
… of inflammation including C-reactive protein, E-selectin and interleukin-6 have been proposed to be newer risk factors for cardiovascular disease. However, the influence of nuts such as almonds on markers of inflammation and hemostasis that influence cardiovascular disease risk is not currently …
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Effects of Linoleic Acid on Tether Formation between Monocytes and Endothelial Cells
… Tether extraction occurred primarily through E-selectin. Treatment with free linoleic acid increased the localization of E-selectin to clathrin-coated pits suggesting an increase in the formation of nanoclusters of E-selectin on HUVECs. The increase in tether frequency was blocked by the U73122 …
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Development of biomimetic microfluidic adhesive substrates for cell separation
… HL60 cells as a model leukocyte cell line and P-selectin as a model receptor. Settling distance of HL60 cells under different shear stresses inside microfluidic channels was identified from the study of convection velocity of cells at different position along the channel. The results show that …
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Rapid 3-D laser microprinting of bioscaffolds and patterning of proteins
… containing microprinted patterns of P-selectin, a protein involved in leukocyte recruitment from blood vessels. We showed that leukocyte rolling occurred on P-selectin patterned collagen channels. Second, we presented a 3-D printed microvasculature by seeding endothelial cells into a …
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
… a dual therapy that targeted both GPIb and P-selectin. The strongest anti-platelet effect was observed with blocking the IIb3 integrin, but this was also associated with a sustained bleeding from the mucosal surface. Overall, the research within this thesis suggests that therapeutic strategies …
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Inflamatory status and leukocyte function during the peripartum period and subsequent effects on reproduction and lactational performance in dairy cattle
… neutrophil surface expression of L-selectin, neutrophil oxidative burst capacity when co-cultured with an environmental Escherichia coli, as well as the secretion of tumor necrosis factor-α and interferon-γ when diluted whole blood were co-cultured with lipopolysaccharide and …
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Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
… BMC phenotypes. Results show that endothelial P-selectin surfaces at 30 minutes post ischemia-reperfusion injury, leading to preferential engraftment of c-kit+ BMCs (which exhibit superior P-selectin adherence in vitro). Chapter 5 adapts the flow cytometry technique to measurement of absolute …
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