Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"segregase"”.
-
Regulation der Transkription durch das Ubiquitin/Proteasom-System
… wird so durch die konservierte CDC48UFD1/NPL4-Segregase, die in dieser Arbeit für S. cerevisiae beschrieben wurde, erkannt. CDC48UFD1/NPL4 entwindet in einer ATP-abhängigen Reaktion den membranständigen Komplex und ermöglicht den Transport von SPT23 p90 in den Zellkern. Interessanterweise …
-
In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome
… of CMG were known, viz the E3 ligase SCFDia2 and segregase Cdc48, very little was known about the mechanism of CMG disassembly. In the process of learning more about the disassembly of the replicative helicase from chromatin, I reconstituted the ubiquitylation of CMG and thereafter the disassembly …
-
The p97 cofactors UBXN7 and UBXN8 interact with and modulate the function of cullin-RING complexes and Fanconi anaemia proteins FANCD2/FANCI, respectively
… protein, which is independent from p97’s segregase activity. We therefore propose that UBXN7 negatively regulates the ubiquitin-ligase activity of CRL2 by sequestering CUL2 in its neddylated form and that this might prevent recruitment of ubiquitin-receptors other than p97 to …
-
Mechanisms of TRIM21-directed intracellular degradation
… was thought to lead to the recruitment of the segregase p97/VCP and the 26S proteosome which together disassembled and degraded the encapsidated virion. In this thesis, I describe my efforts to define the sequential enzymatic mechanism of TRIM21 degradative signaling in greater detail. I report …