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Showing 1 to 7 of 7 for “"secretory phospholipase A2"”.
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Regulation of Secretory Phospholipase A2 by Thyroid Hormone
… risk of hepatic steatosis and atherosclerosis. Secretory phospholipase A2 group IIA (PLA2g2a) enhances the progression of several chronic inflammatory diseases including arthritis and atherosclerosis. The potential linkage of hypothyroidism with inflammation led us to examine the modulation of …
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Mechanism Governing the Cellular Susceptibility to Secretory Phospholipase A2
Secretory phospholipase A2 (sPLA2) is an important part of apoptosis and disposal of damaged and dying cells. However, healthy cells are not susceptible to attack by sPLA2. Recent studies have focused on membrane properties necessary to induce susceptibility in both artificial and biological …
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Mechanisms by Which Apoptotic Membranes Become Susceptible to Secretory Phospholipase A2
… that render them susceptible to hydrolysis by secretory phospholipase A2 (sPLA2). To study the relevant mechanisms, a simplified model of apoptosis using a calcium ionophore was first applied. Kinetic and flow cytometry experiments provided key observations regarding ionophore treatment: …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
<p>Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. …
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Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods
… cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup …
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Changes in tear film biochemistry in end of day ocular discomfort with and without contact lenses
… Concentrations of lysozyme and lactoferrin, secretory phospholipase A2, bradykinin, prostaglandins, cysteinyl leukotrienes, resolvin D1, phosphatidylcholines, lysophosphatidylcholines, sphingomyelins, phosphatidylserines, cholesterol esters, triacylglycerides, wax esters and free cholesterols …
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Mouse modifiers of intestinal tumorigenesis
… containing one candidate gene, the group IIA secretory phospholipase a2 (sPLA2-IIA). Only tumor prone Mom1 strains, such as B6, contain a mutation in sPLA2-IIA abolishing expression. In order to rigorously measure the effect of sPLA2-IIA on the Apdmin tumor phenotype, we have created and …