Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"secretory pathway"”.
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The secretory pathway in peptide hormone-producing cells
Contains fulltext : mmubn000001_234153458.pdf (Publisher’s version ) (Open Access)
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Role of O-GlcNAc in the Vertebrate Secretory Pathway
… consists of protein coated carriers that mediate secretory trafficking from the endoplasmic reticulum. To determine the effects of O-GlcNAc on COPII we used a combination of chemical, biochemical, cellular and genetic approaches to demonstrate that site-specific O-GlcNAcylation of COPII proteins …
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Luminal calcium regulates membrane fusion in the early secretory pathway
… calcium, in regulating fusion in the early secretory pathway has not been thoroughly investigated. Here, I show that calcium has an inhibitory effect on homotypic coat protein complex (COPII) vesicle fusion. In particular, chelation of luminal calcium as well as fast chelation of extra …
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Luminal calcium regulates membrane fusion in the early secretory pathway
… calcium, in regulating fusion in the early secretory pathway has not been thoroughly investigated. Here, I show that calcium has an inhibitory effect on homotypic coat protein complex (COPII) vesicle fusion. In particular, chelation of luminal calcium as well as fast chelation of extra …
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Investigating the protein disaggregation machinery in the early secretory pathway
… from a membrane protein and traverses the secretory pathway. While tau is also implicated in AD, particularly affecting the ER-Golgi secretory pathway, recent research highlights the significance of Aβ due to its initial extracellular processing and subsequent re-entry into neurons. …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
… Ca2+ entry (SOCE). However, how these pathways interact to create precise signals is not well understood. In a pancreatic model of dysregulated Ca2+ homeostasis, secretory pathway Ca2+ATPase 2 (SPCA2) expression is significantly decreased. In the pancreas, only a C-terminally truncated …
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Translational tuning pre-emptively modulates protein folding and secretory pathway defects
… membrane proteins caused by misfolding or secretory pathway disruption. Yor1, the yeast homolog of mammalian CFTR, encodes an ABC transporter that acts as a drug pump to extrude the mitochondrial toxin, oligomycin. A genome wide screen was previously performed in our lab to identify factors …
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Distant chaperones and N-glycan signals : new mechanisms of secretory pathway proteostasis
… one-third of all cellular proteins traverse the secretory pathway. After translation and folding in the endoplasmic reticulum (ER), proteins are transported through the Golgi to their final locations inside or outside of cells. At each step, proteins are helped by chaperones, which both shepherd …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… protein trafficking within the regulated secretory pathway. First, our results establish PACS-1 motifs that regulate nuclear localization through the classical nuclear trafficking pathway. Moreover, we have identified a novel interaction between PACS-1 and the nucleocytoplasmic RNA-binding …
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Targeting and translocation mechanisms in the secretory pathway of the yeast Saccharomyces cerevisiae
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:48:18Z Item is restricted indefinitely.
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Use of the regulated secretory pathway to ease product recovery in animal cell culture
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1994.
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… remodeling of synapses. Defining the signaling pathways that underlie such plasticity has been a major goal of modern neuroscience. BMP signaling critically regulates both morphological plasticity and neurotransmission in motorneurons at the Drosophila neuromuscular junction (NMJ). However the …
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Engineering the Nicotiana benthamiana secretory pathway for the production of Lujo virus vaccines and diagnostic tools
Sub-Saharan Africa is severely deficient in vaccine manufacturing facilities that can keep up with the rate of emergence of viral pathogens. As seen with the Covid-19 pandemic, outbreaks of disease can be extremely detrimental to economies and put severe strain on the public health sector. …
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The p24 family of putative cargo receptors in the early secretory pathway of a prohormone-producing cell
Contains fulltext : 19035_p24_faofp.pdf (Publisher’s version ) (Open Access)
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The SAC1p, an integral membrane protein involved in secretory pathway function and actin function in Saccharomyces cerevisiae
The secretory pathway of the yeast Saccharomyces cerevisiae is strictly analogous to that of mammalian cells. Proteins destined for secretion are transported in a vectorial fashion from the endoplasmic reticulum to the Golgi apparatus to the cell surface. Superimposed on the normal flow of …
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Isolation and characterization of mutations in SEC13, a gene required for multiple steps in the secretory pathway
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Sorting of Cargo Proteins Within the Regulated Secretory Pathway: the Peripheral Membrane Protein HID-1 as a Sorting and Vesicle Biogenesis Factor
… sorting to the constitutive and regulated secretory pathways in real-time and that the bulk of transmembrane LDCV cargoes do not sort directly onto LDCVs, but exit the TGN into non-regulated vesicles to be incorporated to LDCVs at a later step. Additionally, we characterize the TGN …
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Fatty acid synthase is a major polypeptide constituent of cytosolic lipoprotein and is associated with components of the milk lipid secretory pathway
Most of the lipid present in lactating mammary gland cytosol was associated with a high molecular weight aggregate isolated from cytosol by gel exclusion chromatography or by density gradient centrifugation. The major polypeptide constituent of this lipoprotein aggregate was the monomer of fatty …
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Regulation of ovarian oxytocin and prostaglandin F2[alpha] release in the ovine oestrous cycle
… and a possible mechanism by which the oxytocin secretory pathway is controlled in ovarian tissue.
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