Global ETD Search
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Showing 1 to 3 of 3 for “"secretory lysosomes"”.
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
… and peptides. These are targeted for storage in secretory lysosomes and other neutrophil granules for subsequent release by regulated secretion in an inflammatory process. However, the granule content is very potent and may cause tissue damage when released. Basic knowledge about biosynthesis, …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… from the trans-Golgi network (TGN) to secretory lysosomes, followed by generation of membrane-free soluble sTNFR1. The secretion of sTNFR1 could be triggered by a calcium-ionophore or by crosslinking of the IgE receptors on mast cells leading to degranulation. In contrast, …
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Cytotoxic T lymphocyte biology under the microscope
… that the brain isoform of CDC42 is active on secretory lysosomes in CTLs, and controls their polarised secretion at the cytotoxic immune synapse by mediating dynein activation at secretory lysosomes in response to target cell recognition. Whilst attempting to study CDC42 function via …