Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"secretion of insulin"”.
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Genistein-Induced Potentiation Effect on Glucose-Stimulated Insulin Secretion (GSIS) in INS-1 β-cells
Impaired secretion of insulin as well as insulin resistance is a critical characteristic of type 2 diabetes. Thus, correction of the deficient secretion of insulin as well as improvement of insulin action is an important target for prevention of overt type 2 diabetes. Sulfonylureas have been used …
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MICROFABRICATION OF TITANIUM DIBORIDE PATTERNED ON SILICON SUBSTRATES FOR MONO- AND CO-CULTURE OF ENDOTHELIAL AND MESENCHYMAL STEM CELLS
Transplantation of Islet of Langerhans is a treatment used in Diabetes Type I with an objective to introduce beta cells for secretion of insulin for controlling the glucose level in the body. Our project is focused on in vitro culturing of endothelial cells and mesenchymal cells on biocompatible …
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Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
… in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. When insulin resistance develops, the pancreatic beta-cells compensate by in¬creasing their …
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Adiporedoxin, an upstream modulator of endoplasmic reticulum oxidative folding and protein secretion
… greater than other tissues. In gain and loss of function experiments in cultured adipocytes Adrx knock down decreased the secretion of numerous adipokines, extracellular matrix, and transmembrane proteins and over expression increased secretion. Together, these results suggest Adrx regulates …
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The Effect of Insulin on the Nitrogen Metabolism of Teleost Fishes
… presented here has investigated certain aspects of the action of insulin in controlling the overall metabolism of nitrogen in the goldfish (Carassius auratus). Morphological investigations of the Islets of Langerhans have shown them to be closely associated with the ducts of the diffuse exocrine …
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The Role of Akt2 in Hepatic Lipid Metabolism
Insulin drives the global anabolic response to nutrient ingestion, regulating both carbohydrate and lipid metabolism. When insulin resistance occurs in Type 2 Diabetes Mellitus, dysregulation of both of these processes ensues, resulting in hyperglycemia and lipid abnormalities. One of the most …
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to …
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Evaluating the impact of heat stress and altered glycemic state on plasma ɣ-Aminobutyric Acid (GABA) in lactating Holstein cows
Heat stress (HS) induces hyperinsulinemia and hypoglycemia in lactating dairy cows. We hypothesized that γ-aminobutyric acid (GABA) participates in the regulation of this altered glycemic state as it is produced by the pancreatic beta cells and has a stimulatory effect on pancreatic secretion of …
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Exploring Beta Cell NADPH production using Organelle-targeted Apollo-NADP+ Sensors
A major function of beta cells is the production and secretion of insulin to maintain glucose homeostasis. Loss of this function is directly linked to progression of diabetes. The loss of beta cell function is exacerbated by cellular senescence associated with natural aging. Senescence impacts …
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… drug testing commonly relies on the use of two-dimensional (2D) cultures, which allow for rapid drug screening in vitro. However, 2D cultures are unable to capture the complexity of the native three-dimensional (3D) tumor microenvironment, resulting in a lack of correspondence between …
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The effect of magnesium deficiency on the gluconeogenic enzymes with emphasis on the effects of fasting and anorexia
… were carried out to explore the effects of magnesium deficiency on the activities of the hepatic gluconeogenic enzymes. In Experiment I rats were fed, ad libitum, diets adequate (control) or deficient in magnesium for 12 days. One half of the rats from each treatment group were then …
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Nutritional regulation of neural stem cell reactivation in Drosophila melanogaster
… to coordinate brain development with the growth of the organism, neurogenesis is highly dependent on the organism’s nutritional intake. The transition between neural stem cell (NSC) quiescence and reactivation is a key point of regulation during neurogenesis, and in Drosophila, this process is …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… a link between PD development and defective insulin signalling, but the reason is still unknown. Interestingly, besides being expressed in the CNS, LRRK2 plays a crucial role also in the periphery. Noteworthy, LRRK2 is found in several insulin-sensitive tissues including muscle and adipose …
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
… as therapeutic agents. However, the clinical use of protein and peptide therapeutics is still restricted due to undesirable properties such as their ability to self-assemble and aggregate. These properties not only influence production processes and storage but can also have adverse immunogenic …
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ADP regulation of insulin secretion and beta-cell apoptosis
The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and …
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The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases.
… and has helped to change the perspectives of researchers on the concept of the adipose tissue being just a store of energy. As a result of this, adipokines have been reported to represent a connection between obesity and cardiovascular diseases (CVD) and diabetes mellitus. The …
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Physiological, Morphological and molecular biological studies of the effect of Glucagon-like peptide-1 and exenatide in the diabetic rat pancreas
… over 225 million people worldwide. It is often described as a major metabolic disorder, which can result in numerous long-term complications including retinopathy, nephropathy, neuropathy and cardiomyopathy. DM is due to a deficiency of insulin or insulin resistance. Of the 225 million …