Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"secreted protein"”.
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Novel Cell Surface Anchoring Mechanism Of Prokaryotic Secreted Protein
… cell surface is decorated with a variety of protein structures that play important roles in key cellular processes such as providing cell stability, facilitating interactions between cells, and interacting with the environment. One important feature of the biosynthesis of these structures is …
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A novel function of enteropathogenic Escherichia coli secreted protein F within intestinal epithelial cells.
… function of enteropathogenic Escherichia coli secreted protein F within intestinal epithelial cells.
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
… lipocalin (NGAL), also called lipocalin-2, is a secreted protein belonging to the lipocalin family proteins and actively participates into the proliferation, differentiation, and development of human tissues, including tumours. It positively modulates the activity of the matrix …
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HcpE, a potential immuno-modulatory protein from Helicobacter pylori that is dependent on the Disulfide bond protein DsbHP
… H. pylori produces Helicobacter cysteine rich protein HcpE, a secreted protein which may play a role in virulence. In this study we show that HcpE is secreted in the culture supernatant both as a soluble protein and in association with outer membrane vesicles, and may play a role in the …
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Analysis of NFI-X3 and STAT3 Interaction and Its Functions
YKL-40 is a secreted protein that is highly up-regulated in malignant glioblastoma (GBM). Its expression is correlated with the invasive nature of GBMs and poor diagnosis of patients (Nigro et al., 2005). Previous research has shown that in astrocytes and GBM cells, YKL-40 expression is regulated …
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Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems
… of CCL5, CXCL10, CXCL11, IDO, and IFN-β secreted protein levels in the same HLMVEC donor during infection confirmed gene expression findings. The study of host immune responses to hantavirus infection was expanded to include HLMVECs from an additional male and two female donors. …
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Iron-dependent regulation of gene expression in Corynebacterium pseudotuberculosis
… C. pseudotuberculosis growth, and analysis of secreted protein profiles revealed differential expression between low- and high-iron growth conditions. Furthermore, growth experiments conducted in the defined medium revealed that C. pseudotuberculosis is capable of obtaining iron from the host …
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Specific Roles of Kal-1 in Olfaction: A Model of Kallmann Syndrome in Drosophila
… by disruption of the Kal-1 gene, which encodes a secreted protein called Anosmin-1. The definitive features of the KS phenotype are anosmia and hypogonadism. Despite high conservation of the Kal-1 gene from invertebrates to vertebrates, the Kal-1 homolog in mice has not been identified. The …
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Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
… infection, Toxoplasma secretes a large number of proteins into the host cell. Many of these parasite factors modulate the signaling pathways of the host, including the pathway toward NF-[kappa]B activation. The NF-[kappa]B response to infection regulates the direction of host immunity, toward …
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Characterizing phenotypes of Pichia pastoris mutants that show enhanced secretion of recombinant proteins
… and isolate genes that are associated with protein secretion, the Lin-Cereghino laboratory at University of the Pacific created mutant strains of Pichia pastoris using the restriction enzyme mediated integration method. The mutants exhibited an unusual ability to supersecrete …
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Wisp1 Is An Overexpressed Driver of Glioblastoma
… amplified genes in GBM. We identified WISP1, a secreted extracellular matrix protein, to be an overexpressed driver in GBM. Overexpression of WISP1 was able to drive tumor growth in various <em>in vivo</em> models. Knockdown of WISP1 with shRNAs resulted in reduced colony formation <em>in …
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Renal Risk Variants of Apolipoprotein L-1 Form Channels at the Plasma Membrane that Lead to a Cytotoxic Influx of Calcium
<p>Apolipoprotein L-1 (APOL1) is a secreted protein that provides protection against several protozoan parasites due to its channel forming properties. Recently evolved variants, G1 and G2, increase kidney disease risk when present in two copies. In mammalian cells, overexpression of G1 and G2, but …
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A new pathway in the induction of breast cancer
… PBF regulation by oestrogen. PBF mRNA and protein expression were induced by both diethylstilbestrol and 17ß-estradiol in ER!-positive MCF-7 cells. Close analysis of the PBF promoter showed that the region -399 to -291 relative to the translational start site contains variable repeats of an …
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Production and Secretion of Recombinant Human Fibrinogen by the Transgenic Murine Mammary Gland
… advantages for production of heterologous proteins including a high cell density that results in high concentrations of secreted protein and the ability to perform several types of post-translational modifications. Transgenes were constructed from the 4.1 kbp murine Whey Acidic Protein …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… around 75%. MSO pretreatment had no effect on GS protein levels and on kupffer cell (liver macrophages) infiltration in liver. GS and TNF-α transcript levels were unaffected by MSO pretreatment. Also, preliminary results show that MSO does not inhibit cellular and secreted protein synthesis …
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Characterization of PCSK9-mediated LDLR Degradation in Hepatic and Fibroblast Cells
The discovery that proprotein convertase subtilisin/kexin type 9 (PCSK9) mediates degradation of low-density lipoprotein receptors (LDLR) indicates a critical role in LDL metabolism. PCSK9 is a secreted protein that binds to the epidermal growth factor-like (EGF)-A domain of LDLR and directs the …
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Characterization of a Putative Acid Phosphatase in Toxoplasma Gondii and Its Role in Parasite Propagation
… cell, Toxoplasma secretes a large repertoire of proteins beyond the PV to manipulate important host cellular functions. How these Toxoplasma proteins transit from parasites to host cell is not well understood. Protein translocation into the host cell is mediated by three proteins hypothesized to …
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Immunoassay sensitivity and kinetic enhancement in cell culture media using electrokinetic preconcentration
… cell culture proteome from cell lysate or the secreted proteins is often performed by the immunoassay. Macroscale immunoassays such as those performed on the tissue culture plate, however, are of limited use for the microfluidic cell culture due to the limited volume of sample generated by the …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… and inhibition of T cell activity through secreted immuno-suppressive proteins and cytokines, dysfunction of immune cells and upregulation of immune checkpoint molecules. Macrophages are the most populous non neoplastic cells in glioblastoma microenvironment, which is a part of the innate …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… Philosophy</p> <p>We have previously shown that Secreted Protein Acidic and Rich in Cysteine (SPARC) is upregulated in all astrocytoma grades and increases tumor cell migration and invasion. It is thought that different domains within the protein may regulate SPARC functions, suggesting …
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