Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"secondary nucleation"”.
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Primary and secondary crystal nucleation of pharmaceutics
… pharmaceutical and chemical industries. Crystal Nucleation defines the crystal size distribution of the obtained crystal population affecting downstream operations. The literature agrees on crystal nucleation division as primary and secondary nucleation depending on the conditions of the used …
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Study of nucleation mechanisms and rational design of small-scale continuous crystallizers
… Crystallization is a two-step process: nucleation (birth of crystals) and crystal growth. Nucleation can occur via several mechanisms, and the most industrially relevant ones are heterogeneous nucleation (nucleation on a foreign surface), and contact secondary nucleation (nucleation from …
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Drug discovery for misfolding diseases using structure-based iterative learning
… aggregates takes place through autocatalytic secondary nucleation from fibril surfaces, we aim to identify compounds that bind the catalytic sites on the surface of the mature fibrillar aggregates (the end point polymers of the aggregation process). This prevents the formation of the toxic …
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Computational Fluid Dynamics and Population Balance Modeling of Particulate Systems
… for the study of crystal polymorphs as well as nucleation and growth kinetics. An equation is derived which provides the maximum concentration difference within an evaporating droplet. Chapter 3 discusses the secondary nucleation phenomena of breakage due to ultrasonic irradiation of crystals …
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Molecular interactions and their impact on life sciences
… enthalpically driven as it inhibits specifically secondary nucleation processes. In contrast to the specific secondary nucleation inhibition by Brichos, clusterin inhibits specifically fibril elongation of amyloid-beta. I could show that these two specific aggregation processes are affected by the …
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On the Melting and Crystallization of Linear Polyethylene, Poly(ethylene oxide) and Metallocene Linear Low-Density Polyethylene
… In the next step, the Lauritzen-Hoffman (LH) secondary nucleation theory was modified to account for the effect of stem length fluctuations, tilt angle of the crystallized stems, and temperature dependence of the lateral surface free energy. Analysis of spherulite growth rate and wide angle …
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STRUCTURE-BASED APPROACHES TO DATA-DRIVEN PROTEIN FOLDING, AGGREGATION, AND SELF-ASSEMBLY
… of electric fields to disrupt assembly and secondary nucleation. Results demonstrate that multi-eGO can reproduce equilibrium, out-of-equilibrium, and kinetic features, and integrate heterogeneous data sources, such as SAXS and PRE NMR data, to refine the model without the need for explicit …
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Oligomer dynamics for drug discovery against α-synuclein aggregation in Parkinson's disease
… of oligomeric α-synuclein species during secondary nucleation as a drug discovery pipeline that yields more robust links to the in vitro profile of an α-synuclein aggregation inhibitor and its resulting effect on α-synuclein-mediated toxicity in Parkinson’s disease pathology.
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EXPERIMENTAL AND NUMERICAL STUDIES OF BUBBLE DEVELOPMENT PROCESS IN ROTATIONAL FOAM MOLDING
… of four distinct stages: two stages of bubble nucleation, primary and secondary nucleation, followed by bubble growth and bubble coalescence/shrinkage. Following the nucleated bubbles during the foaming process revealed that primary nucleation was the controlling stage in determining the final …
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On transient assemblies in amyloid formation: mechanistic insights and therapeutic strategies
… that α-Synuclein oligomers form through secondary nucleation under physiologically relevant conditions. Using Amyloid-β as a model system, I then examine the impact of mechanical forces on amyloid formation, revealing that shear accelerates aggregation by facilitating the detachment of …
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Containerless processing of stainless steel
… allowed the study of phase selection and secondary nucleation mechanisms for that alloy as well as measurements of delay times and growth velocities. Double recalescence events were observed for the first time at temperatures near the To temperature of the metastable ferritic phase, …
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The Linear Growth Rates of Pentaerythritol Crystals
… usually reported (101) faces. The phenomenon of secondary nucleation appears to be related to the magnitude of the crystal growth rate under the conditions investigated. It appears that (X) may be 1,1,1,trimethylolethane or similar compound.
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Crystal growth and nucleation kinetics of diethylenetriammonium hexachlororhodate (III) salt
… The objective of this work is to determine nucleation and growth kinetics of diethylenetriammonium hexachlororhodate (III) salt. Two reactor configurations, namely a transient continuous stirred tank reactor (CSTR) and a t-mixer plug flow reactor (PFR), were used to determine nucleation and …
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Mitigating protein aggregation to reduce the toxicity inherent to Parkinson’s and Alzheimer’s diseases
… is reduced, and find that it potentiates the secondary nucleation microscopic step in vitro. In Chapter 5, we characterize molecules and antibodies that modify the physiochemical properties and self-association of oligomers comprised of several proteins into clusters with reduced …
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Equilibrium Melting Temperature Determination of Semicrystalline Polymers through Nonlinear Hoffman-Weeks Extrapolation and Secondary Crystallization of Ethylene/Styrene Copolymers
… applicability of the Lauritzen Hoffman (LH) secondary nucleation theory is also addressed for isotactic polypropylene and poly(ethylene oxide). While the LH theory provides an excellent account of the temperature dependence of spherulitic growth rates and ratio of nucleation constants for …
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Pharmaceutical crystallization design using micromixers, multiphase flow, and controlled dynamic operations
… jets and multiphase flow to decouple nucleation and growth so that they can be individually controlled. Various configurations of micromixers were designed to provide controlled nucleation. Based on the dual-impinging-jet (DIJ) configuration, a physical explanation was provided for the …
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Effect of chain structure on the thermodynamics and kinetics of polymer crystallization
… to critically examine the Lauritzen-Hoffman (LH) secondary nucleation barrier model of polymer crystallization. One of the major criticisms of the LH theory was that it predicted divergence of the lamellar thickness and crystal growth rate at finite undercoolings - the so-called “δ𝑙 catastrophe." …
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Mechanistic modeling of alpha-synuclein aggregation and brain pharmacokinetics for drug development in neurodegeneration
… oligomer structural changes, fibril-mediated secondary nucleation, and aSyn–lipid interactions. It enables the evaluation of PD therapeutic strategies targeting different steps of the aggregation cascade, with applications in QSP. The second part tackles specific methodological limitations in …
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Molecular modeling of polymer crystallization and the effect of nucleating agents
… presents new molecular evidence of surface nucleation processes that contribute to the propagation of the crystal growth front in a macromolecular system. Crystallization in polymeric systems has long been theorized to proceed by "secondary nucleation." In this work, molecular dynamics (MD) …
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Investigating the protein quality control pathways that prevent protein aggregation in the social amoeba Dictyostelium discoideum
… inhibits aggregation of mutant Htt at the secondary nucleation step, and I demonstrated that SRCP161-80 does not inhibit pure polyglutamine (polyQ) aggregation, suggesting it interacts with another part of the Htt protein. Finally, I show that SRCP161-80 is also sufficient to suppress …
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