Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"secondary metabolism"”.
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Fusarium poae: Secondary Metabolism and Accessory Chromosomes
… chromosomes can encode transcriptionally active secondary metabolite biosynthetic gene clusters (BGCs), high numbers of transposable elements, and undergo frequent sequence duplications, disruptions, inversions and translocations compared to core chromosomes. The presence of accessory chromosomes …
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The Role of Plasmids in Microbial Secondary Metabolism
Pseudomonas tabaci, P. angulata and P. coronafaciens are three closely related plant pathogens that differ only in their ability to produce the phytotoxin, tabtoxin, their resistance to tabtoxin, and their host specificity. The possibility that the genes for these characteristics were plasmid-borne …
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Geographic and Host-Microbe Symbiotic Influence on Secondary Metabolism
… The scope of this work is to investigate secondary metabolism of both marine and terrestrial organisms from different areas of the world as well as search for the importance of host-microbe symbiosis on a chemical level. Chapter 1 comprises a review of bioactive sponge secondary …
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Characterization of microbial primary and secondary metabolism in the marine realm
… and the predicted composition and production of secondary metabolites. This experience set the stage for my third chapter, in which I developed MetaPathPredict, a machine learning-based tool for predicting the metabolic potential of bacterial genomes. This tool addresses the lack of computational …
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Characterization of Microbial Primary and Secondary Metabolism in the Marine Realm
… and the predicted composition and production of secondary metabolites. This experience set the stage for my third chapter, in which I developed MetaPathPredict, a machine learning-based tool for predicting the metabolic potential of bacterial genomes. This tool addresses the lack of computational …
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Characterisation of Epicoccum spp. secondary metabolism genes through de novo genome and transcriptome sequencing
… in the biosynthesis of epipyrone and other secondary metabolites, the whole genome of Epicoccum italicum strain ICMP 19927 was sequenced using a range of short and long insert shotgun libraries. This was assembled and thoroughly annotated by the funannotate pipeline along with additional …
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Eco-physiological and molecular manipulation of leaf-level primary and secondary metabolism by arthropod herbivory
… to defense or by alterations to primary and secondary metabolism. The type of feeding damage depends on the mouthparts of the herbivore and, in part, determines the magnitude and mechanism by which photosynthesis is altered. However, there is a lack of understanding of these effects across …
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Global and targeted proteomics in Arabidopsis thaliana: A study of secondary metabolism and phytohormone signaling
… one provides background information related to secondary metabolism, phytohormone signaling, and the status of proteomics in plants. In Chapter 2 and Appendix A, we establish the methodology to apply traditional and DiGE-based 2D-GE strategies to global proteomics in Arabidopsis. Our results …
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THE ROLE OF PKS1 MEDIATED SECONDARY METABOLISM IN HOST PENETRATION AND COLONIZATION DURING RICE BLAST DISEASE
MAGNAPORTHE ORYZAE CAUSES DEVASTATING RICE BLAST DISEASES ALL OVER THE WORLD. THIS FUNGUS DIFFERENTIATES A SPECIALIZED INFECTION STRUCTURE, THE APPRESSORIUM, TO PENETRATE THE RICE LEAVES DURING INITIATION OF THE DISEASE. A LAYER OF CONDENSED MELANIN IS FORMED IN THE APPRESSORIUM TO MAINTAIN A HIGH …
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Cell-type specificity and herbivore-induced responses of primary and terpene secondary metabolism in Arabidopsis roots
… or use chemical compounds such as specialized secondary metabolites to resist herbivore or pathogen invasion. Considering the cost-efficiency and energy balance between defense, growth and reproduction, defense reactions in plants have to be regulated temporally and spatially. As more …
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Role of Striatin Complexes in the Control of Development and Secondary Metabolism of the Filamentous Fungus Aspergillus nidulans
… for development. Fungal development and secondary metabolism (SM) requires regulatory complexes which are under control of the environmental signals such as light, CO2 and pH . Aspergillus nidulans is a model for eukaryotic systems as well as fungal development and SM. It produces more …
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The Roles of a Conserved MAP Kinase Pathway in the Regulation of Development and Secondary Metabolism in Aspergillus Species
… such as cell proliferation, immune responses and metabolism, to name a few. In fungal organisms, MAPK pathways have been shown to be involved in the modulation of cell fusion and mating, asexual and sexual reproduction, cellular stress responses and secondary metabolism. MAPK pathways have been …
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The regulation of secondary metabolism from Tolypocladium inflatum, a study on strain improvement in cyclosporin A productivity and its relation to growth and glucose metabolism
… with antifungal activity produced as a secondary metabolite from ' Tolypocladium inflatum'. As its role in transplantation surgery increases, the demands on industry to improve yields intensifies. Mutants showing increased production are compared with strain, MS-1, the original strain …
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The module mir156/spl affects bixin biosynthesis pathway in annatto (Bixa orellana L.)
… other characteristics that may be linked to secondary metabolites production. In this particular, the miR156/SPL module regulates the biosynthesis of sesquiterpenes, flavonoids, anthocyanins, and carotenoids in higher plants. In this context, B. orellana is a promising woody species with an …
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Structural studies of enzymes involved in antibiotic resistance and phosphonate degradation
… structural and functional support. Insights into secondary metabolism in microorganisms have shed light on fascinating arrays of genetically encoded small molecule natural products which have utilized the chemical frameworks of transient high energy compounds, and replaced key labile bonds with …
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Functional and mathematical analysis of the glyoxylate shunt in Streptomyces coelicolor
… Streptomyces, which produces many bioactive secondary metabolites with clinical applications. Based on work done in Escherichia coli, the glyoxylate shunt was thought to be the main anapleurotic pathway in S. coelicolor during growth on fatty acids and therefore an important pathway in …
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Discovery and Characterization of an Antibiotic from the Soil Bacterium <em>Bacillus</em> sp.
… <em>Streptomyces</em>, harbors over 30 genes for secondary metabolism that could be involved in antibiotic production. Several antibiotics have already been reported for <em>Rhodococcus</em>, suggesting the genus may be a good source for new inhibitory compounds. Fifty four soil bacteria were …
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Isolation of a Rhodococcus Soil Bacterium that Produces a Strong Antibacterial Compound.
… to the discovery of a large number of genes for secondary metabolism. Only a few secondary metabolites have been characterized from the rhodococci (including 3 recently described antibiotics). Twenty-four new <em>Rhodococcus</em> strains were isolated from soils in East Tennessee using …
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