Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"secondary hyperalgesia"”.
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Individual Differences in Secondary Hyperalgesia and Associated Neural Activity
… is a mechanism associated with chronic pain, and secondary hyperalgesia is a manifestation of central sensitization that reflects pain felt beyond the site of the injury (Nijs et al., 2021; Woolf, 2011). Secondary hyperalgesia is a stable physiological response, and previous research has …
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The effect of stimulus threat on experimentally induced secondary hyperalgesia
… pain frequently uses a human surrogate model of secondary hyperalgesia that is a common feature of neuropathic pain. The value of experimentally inducing secondary hyperalgesia is that one can then test the influence of different pharmacological and nonpharmacological interventions. This may shed …
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Critical role of ROS in capsaicin-induced hyperalgesia
… were examined in mice. The capsaicin-induced hyperalgesia was used as a pain model since it has 2 distinctive pain components, primary and secondary hyperalgesia representing peripheral and central sensitization, respectively. Foot withdrawal frequencies in response to von Frey filament …
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A tailored biocompatible neural interface for long term monitoring in neural networks
… somatosensory cortex during an episode of hyperalgesia was monitored using implanted neural interfaces in order to further evaluate the probe functionality and usefulness in neurophysiological research. By tracking the development of primary and secondary hyperalgesia as well as allodynia …
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Evaluation of epidural morphine and incisional bupivacaine for analgesia following hemilaminectomy in the dog
… 3 cm from the surgical incision line (primary hyperalgesia) as well as on the lateral aspect of the stifle (secondary hyperalgesia). Assessments were carried out at fixed intervals over the 48 hour postoperative period. Significant differences were found between those groups treated with the …
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The role of Substance P and its signaling pathways in central sensitization
… mechanism of behavioral phenotype, such as secondary hyperalgesia. Substance P (SP) is regarded as an important neuropeptide and mainly exists in primary afferent fibers in the superficial dorsal horn. Release of SP in the dorsal horn can be triggered in response to peripheral noxious …
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Does distress predict central sensitisation in people living with HIV?
… has not been tested. Experimentally induced secondary hyperalgesia (SH) has been used in the laboratory study of other pain conditions (e.g., neuropathic pain) to increase understanding of CS mechanisms. Therefore, the model of SH is useful for investigating pain related to CS, such as pain …
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Modulation of synaptic transmission by TRP channels
… in the spinal cord dorsal horn underlies secondary hyperalgesia. The sensory receptors, Transient Receptor Potential (TRP) channels, are expressed not only at peripheral terminals, but also at the central terminals of sensory neurons. While the role of these channels at the periphery is …