Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"second messengers"”.
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Manipulation of second messengers by ectopic expression of receptors in transgenic Drosophila
… demonstrating the selective manipulation of the second messengers cyclic GMP (cGMP), cyclic AMP (cAMP) and calcium (Ca2+) in the renal (Malpighian) tubule of the genetic model organism, Drosophila melanogaster. The importance of the second messengers cGMP, cAMP and Ca2+ in control of fluid …
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Reactive Oxygen Species are Second Messengers in the Lysophosphatidic Acid Induced Survival Signaling of Ovarian Cancer
… cells, which led us to question if ROS served as second messengers in the aforementioned survival signaling pathways. We challenged SKOV3 cells with antioxidant treatments in the presence of LPA to examine their effects on cell proliferation and Akt, ERK, and NF-κB activation. Two antioxidants, …
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Proopiomelanocortin gene expression in Xenopus laevis melanotrope cells: differential regulation by neuronal factors and role of second messengers
Contains fulltext : 146647.pdf (Publisher’s version ) (Open Access)
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Energy utilization of toad retina: A hydrogen-1 and phosphorus-31 NMR study
… concerning membrane protein interactions and second messengers (Ca$\sp{2+}$ and G-proteins) are generalizable to many other biological systems.
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The development of motility in spermatozoa
… caput and caudal epididymal regions of the rat, second messengers are not effective in stimulating motility, but they are involved once such pH change has occurred. The spermatozoa of Fucus serratus differ from mammalian spermatozoa in that they are released into the sea prior to fertilisation …
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Impact of Second Messenger Modulation on Activity-Dependent and Basal Properties of Excitatory Synapses
… of synaptic properties is often initiated by second messenger signals. Understanding how second messengers sculpt synaptic properties and produce changes in synaptic output is key for elucidating the interplay between network activity and synaptic properties. We studied the effect of second …
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Microvascular endothelial response to cocaethylene exposure: morphological and molecular observations
… barrier function due to changes in intracellular second messengers and signaling. To test this hypothesis, an in vitro model of CE exposure in human dermal microvascular endothelial cells (HMEC-1) was developed. Four Aims were designed to compartmentalize various components of the endothelial …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… of intracellular calcium, which is a crucial second messenger in many chemical signalling pathways, indicated that piezo1 signalling may significantly impact the response of growth cones to chemical signals. I therefore used compliant polyacrylamide hydrogels of defined stiffness to control …
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BEYOND ARABIDOPSIS: UNRAVELLING THE HIDDEN WORLD OF CA2+ SIGNALLING ACROSS SPECIES VIA MULTISCALE IMAGING TECHNOLOGIES
… has revolutionized real-time in vivo studies of second messenger dynamics in plants. This approach already revealed crucial aspects of plant biology, mainly through the use of high-end specialized commercial microscopy systems with the model species Arabidopsis thaliana (Arabidopsis). Among the …
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Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
… is very complex and involves various mediators, second messengers and cell types whose roles in the inflammatory response are being elucidated at the present time. Suplatast tosilate (IPD), a novel anti-allergic drug, plays an important role in the inflammatory process by reducing serum IgE …
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Effect of shear stress on surface membrane potassium ion permeability of calf pulmonary artery endothelial cells (Potassium ion)
… changes in ionic channels and intracellular second messengers in endothelial cells.
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Analyse Gewebe-spezifischer Deletionen der cGMP-abhängigen Proteinkinase Typ I in Mäusen
… weisen darauf hin, dass NO die Synthese des "second Messengers" cGMP bewirkt, welcher die cGMP-abh?xE4;ngige Proteinkinase Typ I (cGKI) aktiviert. Um die in vivo-Funktion der cGKI aufzukl?xE4;ren, wurden bereits konventionelle cGKI Knockout M?xE4;use generiert und analysiert. Da diese …
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The Role of Ca²⁺/CaM-Stimulated Phosphodiesterase 1C in Vascular Smooth Muscle cells of the Synthetic/Activated Phenotype
… methods of clinically modifying levels of these second messengers. Many cardiovascular diseases are associated with a change in vascular smooth muscle cell (VSMC) phenotype, resulting in a hyperproliferative cell devoid of contractile properties. This cell has been defined as …
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The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
… FFA stimulation of GPR40 and both intracellular second messengers in a beta-cell line and insulin release from isolated pancreatic islets. A similarly increased glucagon secretion from alpha-cells was demonstrated after we established that these cells also express GPR40. Antisense knock-down of …
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Functional characterization of equine neutrophils in response to calcium ionophore A23187 and phorbol myristate acetate
… PMN functions differ in their dependence on second messengers in the activation pathway. These functions also occur in a dose-dependent manner and differ in the threshold concentrations required for their stimulation.
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… calcium levels, which possibly involve second messengers (e.g. cAMP). Application of dibutyryl cyclic AMP or Forskolin induced neurite retraction, while 3-isobutyl-1-methylxanthine (IBMX) inhibited neurite outgrowth, suggesting that cAMP is normally produced in cultured RS neurons. The …
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Studies of calcium signalling mechanisms in human platelets
… ion channel activated by the binding of ATP. Second messengers (such as 1,2-diacyl-sn- glycerol [DAG]) and phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) may directly gate plasma membrane cation channels such as the transient receptor potential canonical 6 (TRPC6) channel. -- The main …
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
… (ROS). Beyond their toxicity, ROS are essential second messengers mediating mitogenic signalling. We discovered that oncogene-induced ROS is mediated by the NADPH oxidase NOX4. Upon oncogene activation, NOX4 pharmacological inhibition blocks ROS production, resulting in fork speed reduction and …
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… into local signaling dynamics involving these second messengers in various other systems.
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Submembrane cytoskeleton-regulated assembly and functional activity of gap junctions
… die den Transfer von Ionen, Metaboliten und second messengers zwischen sich berührenden Zellen vermitteln. An vielen Funktionen der Connexine, z.B. zellulärer Transport, Plaquebildung und -stabilität sowie Kanalleitfähigkeit sind Proteine beteiligt, die an die cytoplasmatischen Domänen von …
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