Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 128 for “"second messenger"”.
-
Impact of Second Messenger Modulation on Activity-Dependent and Basal Properties of Excitatory Synapses
… of synaptic properties is often initiated by second messenger signals. Understanding how second messengers sculpt synaptic properties and produce changes in synaptic output is key for elucidating the interplay between network activity and synaptic properties. We studied the effect of second …
-
Autoradiographic Localization of Carbachol-Induced Second Messenger Response in the Rat Spinal Cord Following Inflammation.
This study examined central mechanisms of persistent pain using an autoradiographic technique to localize phosphoinositide hydrolysis (PI) in the rat spinal cord dorsal horn. The lateral half of laminae I-II showed the highest levels of baseline PI turnover and carbachol-stimulated PI turnover in …
-
The involvement of second messenger signalling in impaired integrin function of HIV-1 infected macrophages
Durch die Anwendung von cAMP–Analoga konnte gezeigt werden, dass Komplement-vermittelte Phagozytose (KVP) menschlicher, von Monozyten-abstammenden Macrophagen durch cAMP beeinträchtigt wird. Es war daher theoretisch denkbar, dass die während einer HIV-1 Infektion auftretende erhöhte intrazelluläre …
-
Wirkungen von Ethanol auf das Phosphoinositid-Ca2+-second messenger System in Granulozyten von Patienten mit Alkoholabhängigkeit und gesunden Kontrollen
… (ZNS), insbesondere das Inositolphosphat-Ca2+-second messenger System (IP-Ca2+-SMS), an der Entstehung der klinischen Symptomatik beteiligt sind. Ziel der vorliegenden Arbeit war es, die Auswirkungen von Alkohol auf dieses System zu untersuchen. Da zelluläre Prozesse des ZNS beim Menschen nicht …
-
The M(1) muscarinic receptor and its second messenger coupling in human neuroblastoma cells and transfected murine fibroblast cells
The data of this study indicate that pirenzepine(PZ)-high affinity muscarinic receptors (mAChRs) are coupled to the hydrolysis of inositol lipids and not to the adenylate cyclase system in human neuroblastoma SH-SY5Y cells. The maximal carbachol(CCh)-stimulated [³H]IP₁ accumulation in the SH-SY5Y …
-
Identification and Functional Role of Myo-Inositol Polyphosphate 5-Phosphatase Protein Complexes
… with a receptor, signal amplification through second messenger production, and signal termination through second messenger hydrolysis. Myo-inositol polyphosphate 5-phosphatases (5PTases) (EC 3.1.3.56) have unique signal terminating abilities toward the second messenger inositol trisphosphate …
-
Cellular mechanisms of angiotensin release
… and ligands that stimulate or inhibit second messenger systems in an attempt to understand how the release of ANG is regulated.
-
Role of serotonin in the regulation of aldosterone secretion from the rat adrenal gland
… this steroidogenic effect, describing the second messenger system utilised and in some species the receptor type involved. However the full physiological and pathophysiological role of serotonin in the control of mineralocorticoid secretion still remains to be elucidated.
-
Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
Signal transduction via the phosphoinositide (PI) second messenger system has key roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol …
-
Molecular Characterisation of the Brassinosteroid, Phytosulfokine and cGMP-dependent Responses in Arabidopsis thaliana
… molecules can convert GTP to cGMP in vitro. Secondly, we show that exogenous application of both Phytosulfokine and Brassinosteroid increase changes of intracellular cGMP levels in Arabidopsis mesophyll protoplast demonstrating that these molecules have GC activity in vivo and therefore …
-
Innate Immune Sensing and Signaling of Cytosolic DNA
… cyclic GMP-AMP (cGAMP), as a novel eukaryotic second messenger generated by DNA stimulated or DNA virus infected cells. cGAMP contains a unique phosphodiester linkage combination (both 2'-5' and 3'-5'), for which we referred to it as 2'3'-cGAMP. 2'3'-cGAMP bound to STING with nanomolar affinity …
-
Multidimensional profiling of the Toxoplasma gondii proteome
… are transduced and propagated in cells by secondary messengers. In the asexual and replicating stages of apicomplexan parasites, these pathways initiate and sustain transitions within the lytic cycle responsible for parasite spread and pathogenesis. Among these early-branching parasitic …
-
Manipulation of second messengers by ectopic expression of receptors in transgenic Drosophila
… demonstrating the selective manipulation of the second messengers cyclic GMP (cGMP), cyclic AMP (cAMP) and calcium (Ca2+) in the renal (Malpighian) tubule of the genetic model organism, Drosophila melanogaster. The importance of the second messengers cGMP, cAMP and Ca2+ in control of fluid …
-
Molecular Characterization of Inositol Monophosphatase Like Enzymes in Arabidopsis thaliana
… inositol (1,4,5)-trisphosphate (InsP3), a potent second messenger involved in many biological activities. Arabidopsis contains a single canonical IMP gene, which was previously shown in our lab to encode a bifuntional enzyme with both IMP and L-galactose 1-phosphatase activity. Analysis of …
-
The development of functional in vitro toxicity tests
… in the cell signalling pathway producing the second messenger cAMP, after incubation with dapsone or cyclophosphamide (50µM) and the rat microsomal metabolite generating system. There was also no significant affect on the vasopressin stimulated production of the second messenger IP3, after …
-
An investigation of the role of Arabidopsis thaliana plant natriuretic peptide in planta
… and ion homeostasis in Arabdopsis by examining second messenger responses to stresses that perturb water and ion homeostasis; characterization of an Arabidopsis thaliana plant natriuretic peptide (atpnp-a) mutant and transcriptome analysis of AtPNP-A, in order to establish whether AtPNP-A plays …
-
A Physiological, Biochemical and Structural Analysis of Inositol Polyphosphate 5-Phosphatases from Arabidopsis thaliana and Humans
… to remove a 5-phosphate from various inositol second messenger substrates. To examine the substrate specificity of one of these Arabidopsis thaliana 5PTases (At5PTases), recombinant At5PTase1 was obtained from a Drosophila melanogaster expression system and analyzed biochemically. This analysis …
-
Regulation of Thalamic Neuron Excitability and Intrathalamic Rhythms by Vasoactive Intestinal Peptide
… and are mediated via the cyclic AMP-dependent second messenger system (Chapter 3). In Chapter 4, I describe experiments in which peptide histidine isoleucine (PHI), a closely related peptide to VIP, produces similar actions as VIP. In the chapter 5, I extended my findings regarding VIP actions …
Page 1 of 7