Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"seasonal Influenza"”.
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Modelling the Epidemiological Dynamics of Seasonal Influenza Viruses at Local Scales
Seasonal influenza viruses are a substantial source of disease burden globally, causing epidemics across all climatic regions. Through error-prone RNA replication, influenza viruses can escape pre-existing humoral immunity and reinfect humans, resulting in recurrent epidemics within populations. …
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Immune Response in Young Men to the 2014/15 Seasonal Influenza Vaccine
… the impact of adiposity and physical activity on influenza vaccination. The purpose of this pilot study was to investigate the role of adiposity and physical activity in the immune response of males aged 18-35 to the 2014/2015 seasonal trivalent influenza vaccine. Blood was drawn pre and four …
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A mixed methods study exploring early career doctors’ and medical students’ seasonal influenza vaccination
Seasonal influenza is an acute, contagious respiratory infection that causes considerable morbidity and mortality each year. The Chief Medical Officer for England recommends that healthcare workers have a seasonal influenza vaccination in an attempt to protect both patients and NHS staff. Despite …
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The spatial and temporal anatomy of seasonal influenza in the United States, 1968-2008
Seasonality has a major effect on the spatiotemporal dynamics of natural systems and their populations and is a driving force behind the transmission of influenza in temperate regions. Although the seasonality of influenza in temperate countries is widely recognized, inter-state spread of influenza …
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Improving the analysis of surveillance antigenic data to support seasonal influenza vaccine composition recommendations
Seasonal influenza is estimated to cause 3-5 million infections and 300,000-650,000 deaths worldwide per year. The main countermeasure is vaccination. As the virus evolves to evade the immune system, ongoing surveillance is required to determine if circulating viruses differ substantially from the …
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Predicting the Antigenic Evolution of Influenza Viruses with Application to Vaccination Strategy
Seasonal influenza viruses cause substantial worldwide mortality and morbidity every year. The evolution of these viruses comprise unique systems for studying natural evolutionary processes in real-time. Host immune systems recognise pathogens based on binding affinities between host antibodies and …
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Network and Algebraic Topology of Influenza Evolution
… years ago. In that same amount of time, an influenza virus, which replicates every six hours, would have undergone an equivalent number of generations over only a hundred years. The fast replication times of influenza, coupled with its high mutation rate, make the virus a perfect model to …
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Universal room-temperature stable influenza A nanovaccine
Seasonal influenza A virus (IAV) is annually responsible for an estimated one billion infections, nine million hospitalizations, and 300,000 – 600,000 deaths annually. Considering the potential influenza pandemic threat, the development of a universal IAV vaccine is paramount to global public …
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Humanized mice to test vaccination against influenza virus via dendritic cells.
… To test DC biologyin vivo, we first used live influenza A/PR8/34 (H1N1) virus. Upon intranasal inoculation, all subsets of human antigen presenting cells were activated. Matured DCs were found accumulated in mediastinal lymph nodes. To evaluate the value of these mice for testing human …
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Predicting influenza hospitalizations
Seasonal influenza epidemics are a major public health concern, causing three to five million cases of severe illness and about 250,000 to 500,000 deaths worldwide. Given the unpredictability of these epidemics, hospitals and health authorities are often left unprepared to handle the sudden surge …
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Influenza Modeling, New York City, January 2000 to March 2010
<p>Traditional influenza surveillance methods require all reported cases to have a laboratory positive confirmed diagnosis, causing delays in outbreak detection. Many public health authorities have begun monitoring influenza-like illness (ILI) which does not require a patient to seek medical care …
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Improving Inpatient Influenza Compliance Rates with a Standing Orders Program
<p>Influenza vaccinations are recommended yearly as part of a primary care performance measure to prevent and control seasonal influenza. Rates of influenza are steadily increasing and can lead to severe negative impacts and even fatalities with patients. According to the Center for Disease Control …
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Improving pediatric influenza vaccination rates in the primary care setting
… can reduce caregiver hesitancy, improve influenza vaccination rates, decrease pediatric disparities, improve community health, and reduce healthcare costs. Purpose: The purpose of this quality improvement (QI) project was to reduce caregiver influenza vaccine hesitancy through provider …
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Using design of experiments to improve a batch chemical process
… has made a strong commitment to manufacturing seasonal influenza vaccines through their cell culture technology called Optaflu®. The goal of this project is to improve overall process yield by modifying the upstream process. The focus is on using a batch process to generate a high-density cell …
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Market incentives for pandemic influenza vaccines
… plus individuals could perish if a virulent influenza pandemic were to occur. In wake of the 2009-10 H1N1 pandemic and in an era of economic austerity, however, industry lacks clear incentives to invest in vaccines for other high-risk strains. The cyclic nature of pandemics also means we can …
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Geographic and demographic transmission patterns of the 2009 A/H1N1 influenza pandemic in the United States
… describes how transmission of the 2009 A/H1N1 influenza pandemic in the United States varied geographically, with emphasis on population distribution and age structure. This is made possible by the availability of medical claims records maintained in the private sector that capture the weekly …
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Integration of technical operations and quality teams to build site unification
… to manufacture and fill 50 million doses of seasonal influenza vaccine, and 150 million doses in the event of a pandemic (with the help of a dose sparing adjuvant). All processes, from incoming raw materials to syringe fill and finish, must be conducted at this site in order to meet a United …
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Dissecting Human Antibody Responses Against Influenza A Viruses And Antigenic Changes That Facilitate Immune Escape
Influenza A viruses pose a serious threat to public health, and seasonal circulation of influenza viruses causes substantial morbidity and mortality. Influenza viruses continuously acquire substitutions in the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). These substitutions …
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FMF assay for assessing vaccine generated antibodies in a biomimetic manner
… used for assessing the vaccine response, since influenza vaccine has been administered in people (1940). Such assays are not always predictive regarding the protection conferred by the influenza vaccine and are not able to monitor neutralization related to stem region of influenza hemagglutinin …
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Zeolites Structure, Influenza Evolution and Vaccine Effectiveness, with Prediction of Emerging Flu Strain Clusters
… The second part concerns about the evolution of Influenza viruses and discusses a way to prediction vaccine effectiveness. Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In …
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