Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"sdABs"”.
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Systematic development of rationally designed antibodies targeting predetermined epitopes of interest and protein aggregation
… regions (CDRs) of single-domain antibodies (sdAbs) towards the target regions. This was shown to bind disordered epitopes specifically and with good affinity. The binding was also shown to inhibit the aggregation of αSyn. This approach was also utilized to create multiple sdAbs binding …
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Isolation and Characterization of Anti-SLP Single Domain Antibodies for the Therapy of C. difficile Infection
… recombinant single-domain antibodies (sdAbs), in terms of affinity and specificity, intrinsic stability, and ability to inhibit cell motility. Several sdAbs exhibit promising characteristics for a potential oral therapeutic based on their high affinity, high thermal stability, and …
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Engineering functional recombinant proteins based on antibody domains and fragments of C. botulinum neurotoxin
… For the creation of single domain antibodies (sdAbs), where the antibody domain is engineered to comprise only the variable heavy or variable light chain (and therefore consist of three CDR’s), six of the anti-EGFR sdAbs have been chosen in order to obtain variety of data. All botulinum …
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Cross-reactivity among alphaviruses provides insight into viral emergence and novel defense strategies
… aegypti mosquitoes that express two anti-CHIKV sdAbs to target infection, dissemination, and transmission of MAYV and CHIKV within this deadly vector. These findings are particularly significant because they highlight the ability to co-target two emerging alphaviruses that are crippling public …
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Kinetics of Disordered Proteins and their Interactions
… specially engineered single-domain antibodies (sdAbs) with a modified complementarity determining region (CDR). These complementarity determining regions (CDRs) are often disordered and their dynamics are poorly understood. I performed enhanced sampling simulations of both an sdAb designed using …
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Sélection et caractérisation de Nanobodies inhibiteurs de métallo-β-lactamases
… appelés VHHs, ou « single-domain antibodies » (sdAbs), ils sont considérés comme les plus petits fragments fonctionnels dérivés d’anticorps, et peuvent être facilement sélectionnés par phage-display. Des lamas et un dromadaire ont donc été immunisés avec la MβL VIM-4, ainsi qu’avec d’autres …