Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 811 for “"screens"”.
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Air Bubble Screens
Made available in DSpace on 2014-12-13T19:31:49Z (GMT). No. of bitstreams: 1 7913634.pdf: 6810172 bytes, checksum: 1859443d7d47449148af77a14f7d720f (MD5) Previous issue date: 1978
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House of Screens
… inspiration and gives structure. A house full of screens provides changing spaces and adjustable levels of privacy and protection. Views of one screen layered with another provide changing patterns.
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The alignment of screens
… and surface. It proposes that an inquiry into screens includes, but is not limited to, the study of surfaces. Screens and screening practices are about doing both divisions and vision. The habit of reducing screens to the display neglects their capacity to emplace separations (think of folding …
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Two Screens and an Urban Place
… in terms of architecture and the facade. Two screens make use of pattern, texture, and layering to create a sense of order and chaos within the same instance. This is most noticeable through the introduction of light, natural and artificial. These screens are a reflection of the ripples, webs, …
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Second Screens for Engagement with Political Discourse
… much of it conducted through the use of second screens—personal devices, such as smartphones, tablets, and laptops used alongside television broadcasts.<br/><br/>This research has been motivated by the belief that second screens present an invaluable opportunity to engage the public in political …
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Molecular Players in Lupus: Leads from Proteomic Screens
… diagnosis and treatment of SLE. Proteomic screens identify such markers and provide important clues about disease pathogenesis. We have discovered that soluble Axl receptor tyrosine kinase, the Wnt/β-catenin pathway-related factors, and rare fibrinogen alpha chain variant A-α-E are elevated …
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Investigation of Proliferation Suppressors In Genetic Fitness Screens
… functional profiles. Genome-wide CRISPR knockout screens conducted in collections of human cell lines can knock out genes at multiple loci, and have provided new insights into functional roles for independent genes. This method has launched massive efforts in looking across genetic backgrounds for …
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Network analyses for functional genomic screens in cancer
Gene interference screens are a widely adopted and popular tool for uncovering gene function but imperfections in the technology limit the power of these investigations. There are many completed and on-going RNAi investigations across a multitude of biological systems because these experiments are …
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Behind the screens: How magazines organize for digital success
Change has dominated the media landscape for nearly two decades as digital content creation and delivery mushroomed from the work of secluded upstarts to that of society-influencing giants. Magazine publishers have found varying levels of success in this digital age. Some have thrived; others have …
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Focused CRISPR-Cas9 screens investigating the DNA damage response
… syndromes to developmental disorders. Genetic screens can be used to gain insights into the function of known DDR proteins, identify novel DDR components and highlight potential therapeutic opportunities. We demonstrate that CRISPR-Cas9 gene editing is a useful tool in genetic screens …
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Harnessing CRISPR-Cas9 screens to identify functional genetic interactions
… in high-throughput studies. CRISPR-Cas9 screens have rapidly evolved to become the main approach for unbiased, genome-wide, forward genetic studies. This work seeks to harness the innate potential of CRISPR-Cas9 screens to identify functional genetic interactions. First, we clarified the …
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Computational analyses of small molecules activity from phenotypic screens
Drug discovery is no longer relying on the one gene-one disease paradigm nor on target-based screening alone to discover new drugs. Phenotypic-based screening is regaining momentum to discover new compounds since those assays provide an environment closer to the physiological state of the disease …
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Image-based pooled genetic screens for complex cellular phenotypes
Biological processes are organized in hierarchical interactions of molecules, cells, tissues, and organisms. Cells perform complex functions individually, which when misregulated can result in disease states affecting the entire organism. However, knowledge of the genetic and molecular basis for …
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Genetic screens in vivo using the CRISPR/Cas9 system
… in vivo adopting methods used in genetic screens. By harnessing the information obtained from large datasets in vitro and the utility of cutting-edge endogenous mouse models, the general aim of this work is to create a method that shortens the gap between findings in the lab to viable …
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Molecular analysis of insulin action using high throughput genetic screens
The insulin-stimulated uptake of glucose by muscle and adipose is vital for the maintenance of glucose homeostasis in the body. This uptake primarily occurs through the action of the insulin-regulatable glucose transporter GLUT4, which is rapidly translocated to the plasma membrane in response to …
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Analysis and interpretation of high-throughput chemical-genetic interaction screens.
… at high throughput, chemical-genetic interaction screens can be used to functionally profile entire libraries of chemical compounds in an unbiased manner to identify promising compounds with diverse modes of action. My contributions to the field of chemical-genetic interaction screening come …
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Development of Velocity Profile Generating Screens for Gas Turbine Components
Laboratory experiments on components of complex systems such as gas turbines require many conditions to be met. Requirements to be met in order to simulate real world conditions include inlet flow conditions such as velocity profile, Reynold's number, and temperature. The methodology to be …
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Sacred Screens: Hinduism, Buddhism, Shintoism and Islam in Popular Culture
<p>Popular media content creators have routinely drawn from religious concepts when seeking inspiration for new material. Developers in the West have traditionally relied heavily on Christian themes to supply new ideas. Now, more artists have begun to look towards Hinduism, Buddhism, Islam, and …
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Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
… can help in target elucidation of phenotypic screens. One limitation of previous methods has been the ability to assess the applicability domain of the models, that is, when the assumptions made by a model are fulfilled and which input chemicals are reliably appropriate for the models. Hence, …
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Genetic circuits for functional screens of Cas12a guide RNA libraries
The discovery of CRISPR RNA-guided endonucleases have catalyzed huge technological advancements in the field of synthetic biology, such as the creation of gene drives: genomically encoded CRISPR systems capable of spreading through a wild population. These systems have two components: a …
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