Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"screening strategies"”.
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Modelling HPV Vaccination and Screening Strategies to Optimize Treatment
… the mal-effects of HPV with tools such as screening, vaccination and treatment. Three sets of compartmental models were developed to study various aspects of HPV infection and progression. The first set of models studies which parameters are relevant in screening and vaccination programs …
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Screening strategies for adults with type 2 diabetes mellitus
… randomized controlled trials to address whether screening for type 2 diabetes mellitus (T2DM) improves health outcomes. This systematic review sought to cast a wider net and synthesise evidence from non-randomised intervention studies to assess the effectiveness of T2DM screening in adults for …
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Using Multiple Screening Strategies to Biologically and Chemically Characterize Natural Products
… probes. However, in recent decades therapeutic screening efforts have moved away from using natural product libraries, instead opting for large synthetic molecule library. This move has corresponded with a move from phenotypic screens to target based screening approaches. The perceived …
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Compositional engineering of solution-processed solar cells : aligning computational and experimental screening strategies
… The work presented here pursues both of these strategies by leveraging a central feature of solution-processed solar cells - the ability to control the composition of the active layer by simply blending different ingredients in the precursor solutions. This simple concept provides the …
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Robust and Equitable Public Health Screening Strategies, with Application to Genetic and Infectious Diseases
Public health screening plays an important role in the overall healthcare system. As an example, consider newborn screening, a state-level initiative that screens newborns for life-threatening genetic disorders for which early treatment can substantially improve health outcomes. Another topical …
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A comparative cost analysis of two screening strategies for colorectal cancer in Lynch Syndrome in a tertiary hospital, South Africa
… at an early age. Establishing the costs of strategies to prevent or delay the onset of cancer is, thus, desirable. This study compared the cost of two screening approaches - colonoscopy only (Strategy 1) versus genetic testing for LS followed by colonoscopy for the individuals that tested …
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Mathematical modelling of the population impact of screening for Chlamydia Trachomatis and Neisseria gonorrhoeae in South Africa
… proportion of curable STIs go untreated, as screening for asymptomatic STIs is rarely conducted. Due to the lack of empirical data on the efficacy of STI screening programs, dynamic mathematical modelling has been used to assess the impact of screening, but most previous modelling studies …
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Analytics for Improved Cancer Screening and Treatment
… for advanced cancers and to identify effective screening strategies for detecting early-stage disease. In Part I, we propose a methodology for designing combination drug therapies for advanced cancer, evaluating our approach using advanced gastric cancer. First, we build a database of 414 …
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Benefits and accessibility of OCTA imaging for diabetic retinopathy and macular edema
… to evaluate the cost-effectiveness of different screening strategies incorporating OCTA for the detection and management of DR and DME. A decision tree model (Figure 2) was created to estimate the cost consequences of different screening strategies for clinically significant macular edema (CSME) …
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Mechanistic studies and design of supported transition metal complexes
… broadly develops and applies computational screening strategies for supported TM complexes. First, we detail how weak C-H[superscript ...]O hydrogen bonds can be exploited to increase selectivity of ferrocenium (Fc⁺)-based polymer electrode materials for formate adsorption over perchlorate …
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Methods for Using Biomarker Information in Randomized Clinical Trials
… trials. I propose two new stage 1 multivariate screening strategies using lasso and ridge regressions to account for correlations among biomarkers. For these new multivariate screening strategies, I prove the asymptotic between-stage independence, required for family-wise error rate control. …
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Strategies for Effective Mitigation of Infectious Diseases, with Focus on COVID-19
… and optimizing infectious disease mitigation strategies, with a focus on COVID-19 and closed communities like college campuses. By integrating vaccination and routine screening, we first develop a model to evaluate the efficacy of various strategies in reducing infections, hospitalizations, …
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Host Modulators of the Death Response to Influenza A Infection
… In consequence additional intervention strategies, that target host factors required for the viral life cycle, are under investigation. Here I employed arrayed whole-genome siRNA screening strategies to identify cell-autonomous molecular components that are subverted to support H1N1 …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
… miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small molecule inhibitors represent an attractive approach to pursue this. However, the absence of molecular structures for most of the miRNAs makes it very difficult to predict which …
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Development of a Non-Invasive Proteomic Approach to Profiling Molecular Changes in the Microenvironment to Investigate Stages of Breast Health
… survival rates. However, currently available screening strategies provide ambiguous results, leaving invasive tissue biopsy procedures necessary for definitive diagnosis. Considerable efforts have investigated using nipple aspirate fluid (NAF), a liquid biopsy rich in proteins representative …
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The prevalence of Mycobacterium Tuberculosis in patients with a short history of cough (less than three weeks) at Kamwala, Chilenje and Kabwata Clinics, Lusaka, Zambia
… short history of cough would benefit from PTB screening strategies with emphasis on sputum examination rather than chest x-rays which are unreliable. They include patients with other features of TB and those who are very sick.
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The prevalence of Mycobacterium Tuberculosis in patients with a short history of cough (less than three weeks) at Kamwala, Chilenje and Kabwata Clinics, Lusaka, Zambia
… short history of cough would benefit from PTB screening strategies with emphasis on sputum examination rather than chest x-rays which are unreliable. They include patients with other features of TB and those who are very sick.
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Targeting RNA With Small Molecules: SL3 of HIV -1 Psi-Rna
… target, detailing the basis, challenges and strategies for targeting RNA with small molecules. Chapter two describes how molecules that bind to SL3 RNA were identified using sequentially the docking programs DOCK and AutoDock, followed by MD simulations. These studies revealed nine RNA …
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A genomic investigation into gastrointestinal antimicrobial resistance and clinical infection in patients undergoing transplantation
… Using genomic data, I developed high-throughput screening strategies to aid in the monitoring and mitigation of post-transplant infectious complications caused by gut-residing pathogens. Enteric *E. coli*, *Klebsiella* spp. and *Enterococcus* spp. were identified as significant contributors to …
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The development of a combined simulation approach in a sexual health context: combining discrete event and system dynamics simulation to form a composite model
… has been constructed to evaluate different screening strategies. The SD model incorporates risk groups, ageing, gender, heterosexual and homosexual relationships and migration in and out of the area of interest. A Discrete Event Simulation (DES) model has been constructed of the …
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