Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"scrapie"”.
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… bovine spongiform encephalopathy and sheep scrapie. TSE disease pathology and mechanisms within the central nervous system (CNS) of an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… bovine spongiform encephalopathy and sheep scrapie. TSE disease pathology and mechanisms within the central nervous system (CNS) of an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with …
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Sistema nervoso enterico e scrapie sperimentale in ovini di razza sarda con diversa suscettibilità genetica nei confronti della malattia
… svolga un ruolo cruciale nella patogenesi della Scrapie ovina, non esistono tuttavia in letteratura dati sulle popolazioni cellulari progressivamente coinvolte nel corso dell’infezione, né sugli eventuali danni morfo-funzionali da esse subiti. Il presente studio è stato condotto sui plessi …
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Identification of gene expression changes in Drosophila models of mammalian prion diseases
… These include acquired prion diseases, such as scrapie in sheep, bovine spongiform encephalopathy in cattle and variant Creutzfeldt-Jakob disease in humans. Genetic prion diseases also occur in humans, which are associated with mutations in the prion protein (PrP) gene, such as genetic CJD …
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Proteins as markers of TSE infection in sheep blood
… in phosphotungstic acid (NaPTA) concentrated scrapie-infected and uninfected blood and may represent a novel form of blood-specific PrP. PK-resistant PrPSc is not therefore a suitable marker for TSE infection in blood.<br/>Other proteins in TSE infected blood were also investigated. Using a …
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The role of the 37-kDa/67-kDa laminin receptor in the cellular metabolism of the prion protein
… des abnormalen Prion Proteins, PrPSc, in scrapie-infizierten neuronalen Zellen ist. Scrapie-infizierte neuronale Zellen stellen ein Modellsystem für PrPSc-Infektionen dar. Verschiedene Isoformen von LRP/LR aus Mäusehirn sind identifiziert worden und binden PrPC in overlay-assays. Damit …
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Biochemical, computer, and spectroscopic techniques applied to the study of prions and of combinations of antineoplastic drugs
… in sheep from a Sardinian farm hit by natural Scrapie with the aim to discriminate infected vs. Uninfected, and early vs. late phases of the prion infection (Part II, Chapter I). The overall results, obtained by different chemometric tools, were able to describe a metabolite profile of …
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Assessing the role of Hsp70 in prion propagation in Saccharomyces cerevisiae
… encephalopathies, including; BSE, vBSE, scrapie and CJD. Prions are also present in fungi. There have been a number of prion proteins discovered in the yeast Saccharomyces cerevisiae. Probably the most studied of these is the [PSI+], which is the prion form of the protein Sup35, which is …
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The prion-like properties of assembled human alpha-synuclein
… alpha-synuclein shares features of PrPSc, the scrapie form of the prion protein. The aim of this thesis was to further characterize the prion-like properties of aggregated alpha-synuclein by studying the pathways of seeded aggregation, and to identify the species of alpha-synuclein responsible. …
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Interaction studies of the cellular prion protein
… the role of dimeric prion proteins on the scrapie prion protein formation a covalently-linked PrP dimer was constructed and expressed in yeast Pichia pastoris. The protein was expressed as a glycosylated, proteinase K sensitive protein which is transported to the plasma membrane of yeast …
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Deciphering the Molecular Basis of the Species Barrier in Prion Disease Using Bank Vole PrP
… into a β-sheet rich conformer referred to as scrapie or PrPSc. The infectious nature of this conformer enables it to template the conversion of PrPC into additional copies of PrPSc, the efficiency of which depends on the sequence-encoded structural compatibility of the two molecules. PrPC and …
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pH MODULATION OF FIBRIL DISSOCIATION AND COPPER BINDING PROPERTIES OF THE PRION PROTEIN
… anchor. Conversion of PrP<sup>C</sup> to its "scrapie" conformer (PrP<sup>Sc</sup>, the fibrillar form) constitutes the key event of the etiology of prion diseases. Fibril dissociation is necessary for efficient conversion and continued propagation of the disease state. Recent studies have …
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pH MODULATION OF FIBRIL DISSOCIATION AND COPPER BINDING PROPERTIES OF THE PRION PROTEIN
… anchor. Conversion of PrP<sup>C</sup> to its "scrapie" conformer (PrP<sup>Sc</sup>, the fibrillar form) constitutes the key event of the etiology of prion diseases. Fibril dissociation is necessary for efficient conversion and continued propagation of the disease state. Recent studies have …
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Bacteriology of the reproductive tract of the peri parturient ewe and its relationship with fertility
… This study was affected by the occurence of Scrapie, which led to the culling of many of the ewes studied: Enzootic Abortion of Ewes (Chlamydophora abortus infection) which resulted in a whole flock treatment with parental oxytetracycline in two years and assistance at lambing when …
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Aggregation & Localization of a Disease-Associated Prion Protein (PrP) Mutant
… the extracellular space. When inoculated with scrapie, transgenic mice expressing WT∆GPI display dense intracerebral plaques that are larger and more dense than plaques found in their wild-type counterparts, suggesting that GPI anchor deletion promotes aggregation in infectious prion disorders. …
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Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein
… agents in which a protein, PrPSc (prion scrapie), appears to be the sole component of the infectious particle. They are responsible for transmissible spongiform encephalopathies (TSEs), which affect both, humans and animals. Human prion diseases occur in infectious, sporadic or genetic …
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Studio dell’attività antivirale e/o anti-infiammatoria di nuove molecole di sintesi e/o di farmaci noti
… Atorvastatin and Simvastatin in mice affected by scrapie are ongoing.
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The subcellular trafficking of the prion protein: Characterisation of the function of the PrPc N-terminus
… Creutzfeldt-Jakob disease (CJD) in humans, scrapie in sheep and bovine spongiform encephalopathy in cattle. These spongiform encephalopathies can manifest as sporadic, familial and acquired disorders and are caused by the conformational alteration of the non-pathogenic cellular prion protein …
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The Life of Prion: an investigation into the physiological role of a prion-like protein in the nematode Caenorhabditis elegans
… populations – whether it be in the form of scrapie ravaging through the sheep populations of Spain in the eighteenth century, fatal familial insomnia afflicting families in Italy, or an outbreak of Creutzfeldt-Jakob disease in the UK triggered by the consumption of contaminated beef. The …
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