Global ETD Search
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Showing 1 to 4 of 4 for “"scramblases"”.
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… Ca2+-dependent ion channels and phospholipid scramblases. The TMEM16A and TMEM16B CaCCs conduct Cl- across the membrane and regulate transepithelial fluid transport, smooth muscle contraction, neuronal excitability and sensory signal transduction. Most other TMEM16 members are scramblases that …
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Investigating the Molecular Mechanisms of TMEM16F – a Ca2+ Activated Phospholipid Scramblase and Ion Channel
… that function either as ion channels, lipid scramblases or both. In mammals, the majority of TMEM16 members are Ca2+-dependent phospholipid scramblases (CaPLSases) that catalyze bidirectional movement of phospholipids across the membrane bilayer. Interestingly, some of these TMEM16 CaPLSases …
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A synthetic lipid scramblase built from DNA
… another class of membrane proteins $--$ lipid scramblases. Characterising this DNA nanostructure with gel electrophoresis, dynamic light scattering, atomic force and transmission electron microscopy, we find that the cholesterol groups required for membrane insertion, also induce clustering. …
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Functional Asymmetry of The Immune Cell Plasma Membrane
… by energy-independent lipid channels called scramblases. Although this compositional asymmetry has been known for decades, there has been little investigation of its structural impact on the physical properties of the membrane, nor its functional impact in healthy cells. Here, we seek to …