Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"scramblase"”.
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Inhibiting platelet scramblase activity
… PS exposure is activity of the main platelet scramblase, TMEM16F. This thesis aimed to develop inhibitors of TMEM16F and platelet scramblase activity. R5421 was the only previously described inhibitor of platelet scramblase activity. R5421, however, is shown to be a non-selective inhibitor of …
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A synthetic lipid scramblase built from DNA
… another class of membrane proteins $--$ lipid scramblases. Characterising this DNA nanostructure with gel electrophoresis, dynamic light scattering, atomic force and transmission electron microscopy, we find that the cholesterol groups required for membrane insertion, also induce clustering. …
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Elucidating the Role of Phospholipid Scramblase 1 in Antiviral Innate Immunity
… thesis, I detail our findings that phospholipid scramblase 1 (PLSCR1) works independently of innate immune signaling to oppose SARS-CoV-2 infection. SARS-CoV-2 is a highly contagious virus that was first discovered spreading in human populations in late 2019, having likely jumped from bats to …
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Investigating the Molecular Mechanisms of TMEM16F – a Ca2+ Activated Phospholipid Scramblase and Ion Channel
… that function either as ion channels, lipid scramblases or both. In mammals, the majority of TMEM16 members are Ca2+-dependent phospholipid scramblases (CaPLSases) that catalyze bidirectional movement of phospholipids across the membrane bilayer. Interestingly, some of these TMEM16 CaPLSases …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… calcium signal results in the activation of the scramblase protein, TMEM16F, causing PS to move into the outer leaflet. Flippase activity is also inhibited, removing the route for re-entry of PS into the inner leaflet. It is a combination of these two events that results in sustained PS exposure. …
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Transport properties of DNA nanostructures
… channels so far were developed. The first DNA scramblase which facilitates the translocation of lipid molecules across the membrane was developed. These works represent potential applications of DNA nanostructures in biosensing, nanofluidics, drug delivery and biomedical engineering.
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Functional Asymmetry of The Immune Cell Plasma Membrane
… by energy-independent lipid channels called scramblases. Although this compositional asymmetry has been known for decades, there has been little investigation of its structural impact on the physical properties of the membrane, nor its functional impact in healthy cells. Here, we seek to …