Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"scopolamine"”.
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Characterization of Perphenazine and Scopolamine Aerosols Generated Using the Capillary Aerosol Generator
The characterization of perphenazine and scopolamine aerosols generated using the capillary aerosol generator (CAG) was reported. Variables including steady state power, the formulation vehicle, the drug concentration and the formulation flow rate were studied for their effects on the chemical …
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Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs
… paroxetine were selected for the analysis. Scopolamine and darifenacin were included as positive and negative controls, respectively. Physiochemical properties, pharmacokinetic data, and clinical incidence of AMAEs for the selected drugs were collected from reported literature. Extrapolation …
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Acquisition and retention of an active avoidance response to intense white noise: Kamin effect
… The results of Experiment 3 demonstrated that scopolamine, an anticholinergic drug, alters the typical U-shaped avoidance function whereas methylscopolamine, an anticholinergic which produces the same peripheral effects as scopolamine but passes the blood-brain barrier poorly, does not. These …
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Development and application of novel approaches to quantitate therapeutic drugs in human blood
… of an emerging hypothesis that ‘cutting a scopolamine transdermal patch in half will reduce the side effects associated with the medication while still having effective protection from motion sickness’. The validated assay utilised solid-phase extraction coupled to LC-MS to sensitively and …
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A COMPARATIVE STUDY OF NEWER TECHNIQUES WITH THE OFFICIAL METHOD OF ASSAY OF SOLANACEOUS ALKALOIDS
… official compendia. Atropine, hyoscyamine and scopolamine* are all determined together by a single titration in this method, and the results are expressed as "total alkaloids, calculated as hyoscyaminen". The process is termed a "proximate assay", that is, one in which similar compounds are …
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Pharmacological modulation of learning and memory in mice and zebrafish: Implications for Alzheimer’s disease animal models
… in rodents and in humans such as donepezil and scopolamine. Donepezil was found to reduce the ASR and habituation of ASR in zebrafish larvae, consistent with some reports in rodents. Scopolamine treatment of zebrafish larvae produced a biphasic effect on non-cognitive measures such as ASR and …
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TROPANE ALKALOID PRODUCTION BY DATURA
Atropine and scopolamine, extracted from a variety of plants such as Datura and Scopolla, are among the ten most prescribed medicines derived from plant sources. Increased yields of pharmaceuticals from appropriate plant sources may be effected in a number of ways such as the detailed biochemical …
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A Clinical Investigation of the Use of Promazine Hydrochloride for Pre-Delivery Sedation
… in conjunction with meperidine (Demerol) and scopolamine seem to potentiate the effect and give better analgesia and sedation. Chlorpromazine, however, was unpredictable in response and often left much to be desired. Promethazine has received enthusiastic response by our obstetrical staff and …
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Effects of Reticular Activation on Long-Term Depression in Primary Visual Cortex of the Long-Evans Rat
… had no effect on cortical fPSPs. Application of scopolamine and mecamylamine did not restore LTD or prevent the complex oscillatory activity seen in V1. These results show that excitation of the brainstem activating system blocks the induction of LTD in V1. Thus, higher levels of neural activity …
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Brainstem cholinergic modulation of the limbic learning circuit
… of a cholinergic muscarinic receptor blocker, scopolamine, in the AV nucleus reduced avoidance responding and the amplitude of cingulate cortical excitatory TIA in rabbits trained to asymptotic performance. In Experiment 2, bilateral lesions in the brainstem laterodorsal tegmental (LDT) and …
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Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
… bioactive natural products such as cocaine and scopolamine. The synthesis of these tropinone derivatives, using an asymmetric and intramolecular cascade reaction, allows for facile functionalization of one of the bridgehead carbons. This opens doors to novel derivatives of (-)-cocaine which can …
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The Steroid Sulfatase Inhibitor (p-O-Sulfamoyl) - Tetradecanoyl Tyramine (DU-14) Enhances Memory Retention in Passive Avoidance in Rats with Hippocampal Cholinergic Deficit
… of the enzyme steroid sulfatase could reverse scopolamine-induced amnesia. p-O-(Sulfamoyl) - tetradecanoyl tyramine (DU-14) is a steroid sulfatase inhibitor (SSI) that prevents the conversion of DHEAS to DHEA thereby increasing the concentration of sulfated neurosteroids to potentiate the …
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Interactions between anticholinesterases in an in vitro central nervous system preparation
… of therapy to nerve agent poisoning, along with scopolamine and HI6. In animal studies, this therapy has been shown to lessen the level of incapacitation and increase survivability post poisoning with nerve agent. The exact mechanism of action of physostigmine in this combination is as yet …
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Validation of an animal model of cognitive dysfunction associated with schizophrenia. Development and validation of the novel object recognition task using behavioural manipulations and psychotomimetic dosing regimens to induce cognitive deficits of relevance to schizophrenia in hooded-Lister rats.
… of acute treatment with d-amphetamine, PCP and scopolamine on working memory in the rat. NOR is a visual learning and memory test that measures recognition memory which is impaired in patients with schizophrenia. Studies presented in this thesis demonstrate the importance of careful pilot …
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Ontogeny of contextual fear conditioning: behavioral, neuropharmacological and molecular mechanisms
… Adolescent rats received bilateral infusions of scopolamine (35μg/side) or phosphate buffered saline (PBS) 10 min before all three phases of the CPFE or only prior to a single phase. Intra-mPFC administration of scopolamine prior to all three phases significantly impaired fear conditioning …
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Beans, roots and leaves
… plants: initially hyoscyamine, then hyoscine/scopolamine and atropine. The discovery and characterization of these alkaloids, and the gradual recognition that other pharmacologically useful solanaceous alkaloids (such as duboisine) were identical with one or other of these three compounds, is …