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Showing 1 to 20 of 20 for “"schmidtea mediterranea"”.
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Epidermis and Re-epithelialization in <i>Schmidtea mediterranea</i>
Epidermal layer is crucial for organism’s survival as its ability to close the wound is essential for tissue recovery. Planarian epidermis enables animal recovery and survival after virtually any body part amputation. Nevertheless, neither the epidermis nor the mechanisms endowing such a remarkable …
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Functional genomic studies of regeneration in the planarian Schmidtea mediterranea
Regenerative capabilities are seen in varying degrees throughout the phylogenetic tree. Are the genes and signaling pathways employed by regeneration found in all metazoans and recruited by mechanisms conserved in regenerative organisms, or have organisms developed ways to recruit them de novo? We …
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Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea
Animals can contain hundreds of cell types, each of which has a distinct morphology and function. The transcriptome of a cell dictates this unique cell biology. Recent approaches for high throughput single-cell RNA sequencing have made it possible to generate transcriptomes easily and affordably …
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Investigating Adult Stem Cell Lineage Specification in the Freshwater Flatworm Schmidtea mediterranea
… I have chosen to use the freshwater planarian Schmidtea mediterranea, which possess a large pool of ASCs that supports the constant cell turnover of all their tissues. A transcriptomic approach was used to identify a set of candidate genes to screen for potential regulators and markers of ASC …
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Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… types. Neoblasts are stem cells of the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription factors. We utilize multiplexed error-robust fluorescence …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… germ cell development in planarian species Schmidtea mediterranea. We first identified a S. mediterranea homolog of the conserved early germ cell marker and germ granule component nanos and showed that it is required for planarian germline development, maintenance, and regeneration. Then we …
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Characterization of the hermaphroditic reproductive system and sexual development in the planarian Schmidtea mediterranea
… are two strains of the freshwater planarian, Schmidtea mediterranea: the sexual strain is a cross-fertilizing hermaphrodite with reproductive organs that develop post-embryonically; the asexual strain reproduces by transverse fission and does not develop reproductive organs. This interesting …
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Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
… and pattern the regenerate. The planarian Schmidtea mediterranea is a classic system for studies of regenerative biology in which proliferating cells known as "neoblasts" provide the source of new cellular material for regeneration. Stem cells that might be present within the neoblast …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
Given their regenerative capacity, the planarian Schmidtea mediterranea has emerged as a model system for the study of stem cell biology, tissue specification, and axis formation. Many aspects of the regenerative machinery have yet to be characterized. Although it is known that neoblasts, the …
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Somatic regulation of germ cell development in the planarian Schmidtea mediterranea: the role of systemic and local factors
The student, Amir Saberi, accepted the attached license on 2016-07-12 at 15:54.
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Functional Analysis of Genes Involved in Regulating Stem Cell Maintenance and Differentiation in the Freshwater Planarian Schmidtea Mediterranea
… maintenance and differentiation in planarian Schmidtea mediterranea. A member of the Bruno-like family of RNA binding proteins was found to be critical for neoblast self-renewal in the planarian Schmidtea mediterranea. Smed-bruno-like (bruli) mRNA and protein are expressed in the neoblasts and …
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Schmidtea mediterranea planaris as a novel animal model for investigating the dynamics of nervous system development in fetal alcohol spectrum disorder
… that the freshwater flatworm planarian species, Schmidtea mediterranea, has the capability to fulfill this need. Planaria have the ability to completely regenerate fragments into intact, functional animals, and in these studies, we exploited this property to characterize nervous system …
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ACME and SPLiT-seq: Quantitative and evolutionary single-cell transcriptomics in planarians
… single-cell atlases for the planarian species Schmidtea mediterranea and Dugesia japonica. Later, I use the same pipeline in a single-cell RNA interference study, in S. mediterranea, to describe and quantify the effects of the hnf4 knockdown at tissue-resolution. Our results reveal cellular and …
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teashirt is required for head-versus-tail regeneration polarity in planarians
… family of zinc finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds. Inhibition of Smed-teashirt (teashirt) by RNA interference (RNAi) resulted in the regeneration of heads in place of tails, a phenotype …
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Genetic regulation of neuronal stem cell differentiation: a single-cell sequencing study in planarians
… and functional features. Platyhelminthes like Schmidtea mediterranea continuously turn over all their tissues, including the brain, and can regenerate a perfectly organised and functional central nervous system de novo, from a small body section, within just a matter of days. Such extraordinary …
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An insulin-like peptide regulates size and adult stem cells in planarians
… manner. For example, the regenerating flatworm Schmidtea mediterranea becomes smaller, or degrows, during periods of starvation. These animals provide an opportunity to readily observe adult stem cell population dynamics in response to nutritional cues. We explore the role of insulin signaling …
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How, when, and where: fate selection in regenerative planarians
… all missing cell types. The planarian flatworm Schmidtea mediterranea contains an estimated 150 distinct cell types, which can all be regenerated after injury. Cell-type production in planarians is regulated by the expression of fate-specific transcriptions factors (FSTFs) in dividing cells …
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Liquid chromatography-mass spectrometry-based neuropeptide characterizations across neuronal models
… have been explored. For example, the flatworm (Schmidtea mediterranea) provides understanding of regeneration and reproduction, while the comb jelly (Pleurobrachia pileus), as the earliest branching in extant animals, is an excellent model for investigating animal evolution. The ability to …
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Branching out: how a planarian neoblast generates cellular diversity
… types of specified neoblasts in the planarian Schmidtea mediterranea by using single-cell RNA sequencing. We also profile their post-mitotic descendants that serve as migratory progenitors. Through these analyses, we uncover many novel neoblast and post-mitotic progenitor types, and the genes …
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Characterization of germ cell development in free-living and parasitic flatworms
… flatworms. We use the freshwater planarian Schmidtea mediterranea to understand the functions of germ cell-specific genes crucial for the development and proliferation of early male germ cells. Additionally, we also characterize genes essential for the tremendous reproductive output of the …