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Showing 1 to 20 of 149 for “"scd"”.
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An Examination of the Biopsychsocial Risk Factors for Cognitive Development of Children with Sickle Cell Disease
… for children diagnosed with Sickle Cell Disease (SCD) have been found to impact their cognitive functioning; however few studies have investigated the possible interactions of these risk factors. SCD is a chronic, hereditary, hemoglobinopathy which is most commonly found in individuals of African …
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The social meanings of a child with sickle cell disease in Ghana: Fathers' reactions and perspectives.
Sickle cell disease (SCD) is a chronic inherited blood disorder affecting nearly a quarter of a million infants born in Africa each year. Historically it was estimated that over 95% of babies born with SCD in rural Africa died before 5 years old. In Kumasi, the second city of Ghana, where 2% of all …
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Superior semicircular canal dehiscence : auditory mechanisms
Superior semicircular canal dehiscence (SCD) syndrome is a recently defined clinical disorder in which patients present to the clinic with vestibular symptoms, auditory symptoms, or both. Understanding the effect of SCD, a hole in the bony superior canal, on hearing will broaden our understanding …
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Subjective cognitive decline and related worry: Examining biopsychosocial correlates in mid-age and older Canadians
Introduction: Subjective cognitive decline (SCD), a self-reported decline in cognition in otherwise cognitively healthy people, has been acknowledged as a risk factor for Alzheimer’s disease. Using data from the Canadian Longitudinal Study on Aging (CLSA), a large national study with participants …
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Increasing Sequential Compression Device Compliance to Decrease Venous Thromboembolisms and Improve Nursing Documentation
… devices, such as sequential compression devices (SCD). However, less than half of hospitalized patients receive VTE prophylaxis (CDC, 2017). At a large metropolitan hospital, compliance with VTE prophylaxis, specifically with SCDs, is an ongoing quality improvement project. Currently, SCD usage …
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Elucidation of the Mechanism of Action of a Cell Line Selective Toxin
… into irreversible stearoyl CoA desaturase (SCD) inhibitors. SCD has been recognized as a promising biological target in cancer and metabolic disease. However, SCD is essential to sebocytes, and accordingly SCD inhibitors cause skin toxicity. Mouse sebocytes were unable to activate the …
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Real-world Pharmacological Anticoagulation and Clinical Outcomes of Venous Thromboembolism in Adults with Sickle Cell Disease
<p>Sickle cell disease (SCD) is an inherited disease characterized by sickle-shaped red blood cells that can slow or block blood flow. It affects about 100,000 people in the United States, and occurs more commonly in people of African descent. SCD is considered as a hypercoagulable state and venous …
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Healthcare Resource Utilization in Persons with Sickle Cell Disease
… to determine prevalence of sickle cell disease (SCD) in a Medicaid population, to determine all-cause health care resource utilization and incremental health care resource utilization associated with SCD. An observational database analysis was conducted using information from a large …
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Characteristics of cardiovascular dysfunction and pulminory hypertension in patients with sickle cell disease
Background<br/>Sickle cell disease (SCD) is a hereditary hemoglobinopathy that causes chronic<br/>complications due to repetitive vaso-occlusive events and hemolysis, and can<br/>lead to multiorgan failure and shortened life expectancy. Among a spectrum of<br/>cardiovascular manifestations in these …
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Study of Rehydration Properties of Powder Produced from Chelated Skim Milk
… acid (EDTA) or sodium citrate dihydrate (SCD) at concentrations of 5, 10, and 15 mM to skim milk prior to evaporating and spray drying. The objective of this investigation was to determine the effects of the chelator additions on each SMP rehydration property (wettability, sinkability, …
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Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
<p>Sickle cell disease (SCD) is a dangerous condition caused by a genetic mutation on the human beta-globin gene that contributes to erythrocyte sickling, the hallmark of the disease. Previous metabolomics studies have confirmed that elevated sphingosine kinase 1 (SphK1) mediates …
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Risk factors associated with blood pressure variation in sickle cell disease in Cameroon
Background: In SCD patients, studies have shown that increased Blood Pressure (BP) is associated with higher risk of stroke and mortality, even in a range of systolic BP(SBP) and diastolic BP(DBP) that are considered relatively normal for the general population (i.e., lower than 140 mmHg). SCD …
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Different Methodologies to Characterize and Diagnose Sickle Cell Disease in Both Developed and Developing Nations
<p>Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection …
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Le Rôle de la stéaroyl-CoA désaturase-1 dans le maintien de la prolifération des cellules T et de la lignée leucémique Jurkat
… on s'intéresse à l'étude du rôle de la SCD-1 dans la prolifération cellulaire. Dans cette étude, nous avons étudié le rôle de la SCD-1 dans la lignée cellulaire leucémique Jurkat et dans les cellules T du sang périphérique. L'effet de l'inhibition de la SCD-1 sur les cellules T …
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Sickle cell disease associated co-morbidity with pneumonia outcomes among under-five children referred to university teaching hospital between 2011-2014 in Lusaka, Zambia
Pneumonia in sickle cell disease (SCD) can be particularly severe and has come to be called acute chest syndrome (ACS). ACS is a frequent complication of sickle cell disease in patients hospitalized with vaso-occlusive crisis (VOC). It is associated with a high risk of sickle cellrelated mortality …
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Sickle cell disease associated co-morbidity with pneumonia outcomes among under-five children referred to university teaching hospital between 2011-2014 in Lusaka, Zambia
Pneumonia in sickle cell disease (SCD) can be particularly severe and has come to be called acute chest syndrome (ACS). ACS is a frequent complication of sickle cell disease in patients hospitalized with vaso-occlusive crisis (VOC). It is associated with a high risk of sickle cellrelated mortality …
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The Dissociation of Sensory Integration and Associative Learning in Caenorhabditis elegans and the Molecular Mechanisms Leading to Memory Acquisition
… lrn-2, was characterized and mapped to the scd-2 gene, which expresses a receptor tyrosine kinase. scd-2 plays role in both sensory integration and associative learning, and was used to dissociate these two processes at the genetic, cellular, and behavioural levels. At the genetic level, it …
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Understanding Fatigue in Pediatric Sickle Cell Disease
Fatigue is a problematic symptom for adults with SCD and other pediatric populations, but less is known about the experience of fatigue for youth with SCD. The present study described the experience of fatigue in children and adolescents with SCD, and examined the combined and unique influences of …
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Genetic Analysis of Bacterial Food Perception and its Influence on Foraging Behavior in C. elegans
… Two, I characterize a gain-of-function allele of scd-2, the C. elegans Anaplastic Lymphoma Kinase (ALK) gene ortholog, scd-2(syb2455),which I designed based on an oncogenic mutation in ALK. While animals with loss-of-function mutations in scd-2 are dauer-formation defective, scd-2(syb2455) animals …
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