Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"scavenger receptor"”.
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Role of scavenger receptor MARCO in particle uptake and lung inflammation
… the role of membrane glycoproteins called scavenger receptors in binding of environmental particles. The scavenger receptors are classified into different classes (A-H) based on their structure and function. Class A scavenger receptors are critical in uptake of variety of ligands such as …
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Role of scavenger receptor MARCO in particle uptake and lung inflammation
… the role of membrane glycoproteins called scavenger receptors in binding of environmental particles. The scavenger receptors are classified into different classes (A-H) based on their structure and function. Class A scavenger receptors are critical in uptake of variety of ligands such as …
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The role of scavenger receptor B-I in hepatitis C virus attachment and entry.
… on at least three cellular entry factors: CD81, Scavenger Receptor B-I (SR-BI) and Claudin-1. SR-BI is a receptor for high density lipoprotein (HDL), it is predominantly expressed in the liver and steroidogenic tissue. HCV is believed to interact with SR-BI via the viral envelope protein E2, …
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Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1
… Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a post-transcriptional, tissue-specific decrease in SR-BI protein level and an increase in total plasma cholesterol carried in abnormally-large HDL particles. A greater …
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The influence of oxidised low density lipoproteins on platelet activation
… activating platelets through G protein coupled receptors stimulate MLCSer¹⁹ phosphorylation by the activation of dual pathways that lead to a Ca²⁺ dependent activation of MLC kinase (MLCK) and the Rho kinase dependent inhibition of MLC phosphatase (MLCP). OxLDL induced platelet shape change …
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Potential Modifications to Enzyme Replacement Therapy in Anderson-Fabry Disease
… on targeting of αGal to the very high uptake scavenger receptor (SR) for improved transport to the lysosome.</p>
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Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study
… innate immune system of the nematode. Toll- Like receptors (TLRs) are important mediators of innate immune responses to Candida albicans, and several classes of scavenger receptors have been implicated in recognizing and reacting to a variety of ligands in humans[4]. The C. elegans genome encodes …
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Analysis of the function and subcellular localization of FAT/CD36 in hepatocytes and transfected cell lines of hepatic and non-hepatic origin.
The class B scavenger receptor CD36, or fatty acid translocase (FAT), is an 88 kDa plasma membrane glycoprotein that is the founding member of the class B scavenger receptor family. It has a number of natural ligands and has different functions at various locations in the body. It contributes to …
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Monocyte Modulation of Disease Pathogenesis and Progression in Localized Aggressive Periodontitis
… the differential expression and function of the scavenger receptor CD36. LAgP monocytes have exhibited decreased activity of the PAF-acetylhydrolase (PAFAH), the catalytic enzyme that breaks down PAF. Since PAF levels are regulated by synthesis and degradation, we hypothesized that synthesis by …
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Analysis of genetic variation in Pediculus humanus and Populus trichocarpa
… Serpin (PHUM311330), Cactus (PHUM345810), Scavenger receptor A (ScavA; PHUM066640) and Apolipoprotein D (PHUM427700). Increased expression of Fibrinogen-related protein and Spaetzle, both related to the Toll pathway, in treated body lice supports the hypothesis that body lice are fighting …
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Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… vitro in a nitric oxide-independent manner via scavenger receptor B type I (SR-BI)-mediated activation of Rac GTPase. This process does not require HDL cargo molecules, and it is dependent on the activation of Src kinases, phosphatidylinositol 3-kinase, and p44/42 mitogen-activated protein …
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CHOLESTEROL ABSORPTION AND TRANSINTESTINAL CHOLESTEROL EFFLUX (TICE) RATES ARE UNALTERED IN MICE OVEREXPRESSING INTESTINAL SR-BI.
… regulating TICE. It has long been known that scavenger receptor class B type I (SR-BI) plays a crucial role in RCT in the liver by facilitating selective uptake of high density lipoprotein (HDL) cholesterol. Interestingly, SR-BI is also expressed in the small intestine. Previously it has been …
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Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… the lateral diffusion and clustering of the scavenger receptor CD36. Consequently, CD36 more readily engages and internalizes cholesterol-rich, oxidized low-density lipoproteins, leading to the accumulation of cholesterol esters within macrophages, and thus, the acceleration of foam cell …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
… clathrin- and pH-dependent, and requires CD81, Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be efficiently cultured in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context …
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Characterising the role of haptoglobin in experimental subarachnoid haemorrhage.
… CSF Hp and soluble CD163 macrophage haemoglobin scavenger receptor from baseline, concomitant with the Hb peak at the 24hr mark, with a steady and rapid taper off, in keeping with clearance of free Hb by 72hrs post-SAH. Additionally, histological assessment to examine macrophage receptor for …
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Role of SFLT-1 in vascular regulation in pregnancy and its effect on fetal vascular programming
… inhibition of these factors by a circulating scavenger receptor, soluble VEGFR-1, also called sFlt-1, is believed to play a role in the pathogenesis of preeclampsia. \r\nWe created a mouse model of preeclampsia induced by administration of adenovirus carrying sFlt-1. We have shown that …
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Analyse der Annexin-1-Expression und Identifikation neuer Glukokortikoid-stimulierbarer Gene durch Differential-Display-RT-PCR-Methodik in humanen Makrophagenkulturen
… genes as metallothionin-2 or the RM 3/1-CD163 scavenger receptor but also new genes such as the catalase or other hitherto unknown genes.
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Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
… to entry was shown to occur downstream of CD46 receptor expression and BVDV binding, suggesting interference with a yet unidentified BVDV entry factor. In contrast to BVDV, HCV-infected and replicon-containing cells exhibit a post-entry block to superinfection, at one or more steps in viral …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
… placental choriocarcinoma cell lines through scavenger receptor-mediated endocytosis. Next, we observed that S.Tm failed to grow vigorously in macrophages, but replicated rapidly within epithelial and placental trophoblast cells. Further examination of intracellular localization of S.Tm …
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Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression
… profiling strategy and discovered a multi-ligand scavenger receptor CD36 is rapidly upregulated in multiple cell types in response to replicative, oncogenic and chemical senescent stimuli. Moreover, ectopic CD36 expression in dividing mammalian cells is sufficient to initiate the production of a …
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