Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"scar formation"”.
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hepatocyte growth factor inhibits glial scar formation and
Formation of glial scars physically impedes growth of regenerating axons following CNS injuries such as spinal cord trauma. Glial scars also produce various species of chondroitin sulfate proteoglycans (CSPGs) that act as a potent inhibitor of axon growth. Thus, inhibition of glial scar formation …
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Cd44-Mediated Collagen Remodeling Drives Wound Resolution And Pancreatic Tumorigenesis
… hyaluronic acid (HA), contributes to exacerbated scar formation and promotes tumorigenesis. Thus, defining underlying mechanisms governing these processes is vital to understanding disease progression. CD44 is a transmembrane cell-adhesion receptor that primarily binds to HA, the predominant …
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A biocompatible, local drug delivery platform for the chronic treatment of neurological disorders of the brain
… to treat circuit diseases of the brain. Glial scar is a major barrier to neural probe function. A main objective of this thesis is focused on understanding the process of glial scar formation from a materials perspective. Micromotion and mechanical mismatch are thought to be key drivers of scar …
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The use of biomaterials for stem cell therapies to prevent myocardial damage post-infarct
… of functional myocardium with non-contractile scar tissue. Because of this scar formation, survival of the initial heart attack is commonly accompanied by a decrease in left ventricular functioning due to wall thinning and ventricular enlargement. As a result of the slow, or absent, ability of …
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Bioinspired alterations of collagen-glycosaminoglycan scaffolds for tissue regeneration applications
… by the development of granulation tissue (scar) which lacks the structural and functional properties of the native tissue's extracellular matrix (ECM). Scar formation has been linked to the presence of inflammation, as injuries in environments with little inflammation (e.g. fetal) heal via …
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Spinal cord regression via collagen entubulation
… analyses showed severe fibrous and glial scar formation in Groups I and III, less fibrous scarring in Group II and very little scar manifesting in Groups IV and V. A quantitative analysis of myelinated axons in the center of the explants corresponded with the assessment of scar as a …
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mIGF-1 regulates heart physiology and induces complete regeneration of infarcted myocardial tissue
… disease, suffering tissue deterioration, scarring and loss of contractile function. Clinical interventions to prevent or reverse the devastating effects of cardiac damage have met with limited success, presumably due to restricted cardiac regenerative potential. We tested the ability of a …
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REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR
… surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers have focused on methods to accelerate axon outgrowth. Electrical stimulation …
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Development of a novel co-culture based in vitro model system to study the wound healing process
… due to the complex nature of wound healing and scarring processes and the limitations of available in vitro or in vivo models used for preclinical drug testing. Many patients who undergo elective back surgery develop post-surgical complications resulting from excess peridural scarring in and …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… voice, after laryngeal injury is vocal fold (VF) scarring, which typically follows upper airway trauma or iatrogenic injury. After initial VF damage, immune cells infiltrate the wound bed and secrete various cytokines, including transforming growth factor-β (TGF-β), to promote tissue repair. In …
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Characterizing hydrogel imposed strain fields on brain tissue phantom for use in neural implant device coatings in presence of micromotion
Glial scar tissue forms in the brain as a response to the implant injury and hampers the effectiveness of the implant treatment. Constant relative micromotion between the mechanically mismatched neural implant and brain tissue is thought to play a key role glial scar formation. This study …
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Causal factors and consequences of mixed-severity fire in Black Hills ponderosa pine forests
… scopulorum) forests are reconstructed from fire scar and tree origin information. Fire frequency, severity, and size are inferred from dates of fire occurrence as recorded as scars on individual trees and from cohort origin and structure. However, little is known about rates of fire scar …
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Finite Element Analysis on the skin properties affecting wound closure
… of skin that affect skin wound closure and scar formation. It begins with an in depth literature review of mammalian studies and computer simulations of skin wounds, providing a better understanding of the mechanics of skin during wound healing. Details are then provided into the …
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PERICYTE SUBTYPES AT THE INTERSECTION BETWEEN TISSUE REGENERATION AND PATHOLOGY
… infiltration after wounding. Excessive scar formation compromises tissue function and can lead to organ failure. Cells called pericytes, located around blood vessels, act as stem cells. Some studies suggest that pericytes may contribute to regeneration in various organs as well as …
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The evaluation of fibrin tissue adhesive for skin closure following eyelid surgery
… that induces physiological clotting and fibrin formation is appealing in both theory and clinical practice. However fibrin tissue adhesives present disadvantages and complications of their own. This thesis set out to evaluate the use of fibrin tissue adhesives in eyelid surgery and includes a …
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Evaluation of the Harmonic Scalpel for Laparoscopic Bilateral Ovariectomy in Standing Horses
… emphysema in another, and incisional seroma formation in a third mare. Post-mortem examination 3 and 30 days postoperatively revealed no signs of generalized peritonitis, postoperative hemorrhage or adhesion formation. Mild to moderate acute inflammation, and scar formation with moderate …
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Klinische und psychologische Aspekte bei brandverletzten Kindern : eine Langzeitstudie des Verbrennungszentrums Aachen
… 1998 in the burn centre Aachen. In addition, the scars and the psychological adjustment in children after a severe burn injury (>=10% TBSA = total burn surface area) were investigated. Approximately 30-40% of all burn injuries happen to children. Burns are the second reason of accidental death in …
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The Role of Oxidative Stress in Skeletal Muscle Regeneration
… for the prevention of long-term fibrosis and scar formation and improvement of recovery of muscle function.
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Towards Establishing Methods of Synthesis, Purification, and Structural Determination for Human Fibrinogen
… growth factor receptor pathway activation, scar formation, and immune response, yet many questions remain about fibrinogen's structure-function link in these various pathophysiological states. Studies focused on improving expression systems for recombinant fibrinogen, and developing more …
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The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… disease that resolves with or without permanent scars depending on the subtype. Interferons (IFNs), including the skin specific IFNλ mainly activate STAT1, which results in inflammation in CLE and may play a significant role in scar formation in chronic discoid CLE. IL-22 activates STAT3 and it …
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