Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"scalable methods"”.
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Scalable Methods for In Situ Genomics
… spatial context, however, existing genome-scale methods lack either base-pair sequence information or direct spatial localization. To overcome these limitations, we invented In Situ Genome Sequencing (IGS), a set of scalable methods for simultaneously sequencing and imaging cellular genomes …
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Scalable methods for immune repertoire sequencing
… at a repertoire scale are rarely economical or scalable. In this thesis, we discuss two separate advances in immune repertoire sequencing. In the first aim, we describe a high-throughput tool to identify antigenic peptides capable of being presented on class I MHCs. This platform utilizes yeast …
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Scalable Methods for Processing Massive Geometric Meshes
Polygonal meshes are easily the most common surface representation currently employed in computer graphics, finding application in fields as diverse as the visual arts and scientific computation. Technological advances in the areas of three-dimensional scanning, digital storage, and computer …
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Scalable methods for navigating large annotation collections in NB
… of NB, and looking at other platforms, we found methods for students to navigate through the large collections of annotations. These methods include having statistics for each document, the ability to endorse a comment, follow authors, and minimize the number of comments on a document. Once these …
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ULTRA SCALABLE METHODS FOR DIFFERENTIAL TESTING OF SPATIAL-OMIC DATA
… cells from their native environments, spatial methods retain information about each cell’s physical location and neighborhood. This spatial context enables researchers to explore how cellular processes such as gene regulation are influenced by microenvironmental cues like intercellular …
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Scalable methods for the discovery of autophagy and disease genes
… and medical research. This thesis develops scalable experimental and computational methods for the discovery of autophagy genes and elucidation of their relationships to human disease. To enable scalable genetic screens for autophagy, we develop two high-throughput autophagy assays: (1) an …
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Scalable methods for storage, processing and analysis of sequencing datasets
Massive amounts of next-generation sequencing (NGS) reads generated from sequencing machines around the world have revolutionized biotechnology enabling wide-scale disease and variation studies, personalized medicine and helping us understand our evolutionary history. However, the amount of …
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Development and Demonstration of Scalable Methods for Research on Human Factors in Driving
… dissertation research was to develop efficient methods to support detailed research on driving human factors. The methods that I used included 1) realistic rendering of driving scenarios in computer graphics generated videos, 2) simplified mental workload assessment using ratings of workload …
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Discrete mechanical metamaterials
… for example, is one of the leading methods for rapid prototyping and near net shape part production. Extension to full scale structures and systems, however, remains a challenge, as cost, speed and performance present orthogonal objectives that are inherently coupled to limited …
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Towards reconstructing cities with AI: a novel machine learning approach for automated archaeological surveying and preservation by learning canopy structures
… climate change and human activity, necessitating scalable methods for site detection. LiDAR has revolutionized archaeological surveys by revealing features beneath dense vegetation, but manual interpretation remains labor-intensive. This study introduces an Automated Archaeological Survey Method …
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Scaling Up Network Analysis and Mining: Statistical Sampling, Estimation, and Pattern Discovery
… propose sampling as well as fast, efficient, and scalable methods for network analysis and mining in both static and streaming graphs.
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Scalable Multi-label Classification
… correlations between them. Consequently, many methods do not scale up to large problems. This thesis deals with scalable multi-label classification: methods which exhibit high predictive performance, but are also able to scale up to larger problems. The first major contribution is the pruned …
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Scalability and interpretability of graph neural networks for small molecules
… chemistry with an emphasis on interpretable and scalable methods. I propose a novel kernel-inspired graph neural network architecture, called a subgraph matching neural network (SMNN), which is designed to have all feature representations and weights be human interpretable. I show that this …
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Modeling and algorithms for optimizing beam steering optical crossconnects
… about each connection is already known. Scalable methods for representing the per-connection transmissivity model are also studied. Experimental results of the algorithm performance on real crossconnect systems are reported, including connection setup in under 50 milliseconds.
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Experimental Investigations on Non-Wetting Surfaces
… First, SHS and LIS are fabricated using robust, scalable methods and tested for durability in heated, wet conditions and under high-energy water jet impingement. Clear performance differences are shown based on surface texturing, functionalizing agent, and infused lubricant. Second, SHS and LIS …
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Self-assembly of magnetic nanoparticles: A tool for building at the nanoscale
… over material properties. However, robust and scalable methods for arranging nanoparticles are still lacking. This dissertation explores the use of an externally applied magnetic field to organize magnetic nanoparticles into microstructures of desired shape. It extends to proofs of concept …
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Reliably arranging objects : a conformant planning approach to robot manipulation
… provides insight and develops approaches toward scalable methods for solving challenging planar manipulation problems with multiple objects or concave shape geometry. We show the success of these approaches based on planning times and robustness in real and simulated experiments.
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Scalable Methodologies for Optimizing Over Probability Distributions
… problems, there has been a shortage of scalable methods grounded in mathematical principles. To bridge this gap, this thesis introduces two complementary lines of work for scalable distributional optimization. The first part of this thesis focuses on optimizing over discrete …
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Digital cellular solids : reconfigurable composite materials
… approach in designing new cellular materials and methods for assembly of structures with static reconfigurability. The science of cellular solids has enabled the widespread use of lightweight materials to meet important engineering needs, such as passive energy absorption, but they are not in …
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Scalable Quantum Compilation Approaches For Reliable Quantum Computing
… quantum hardware. Therefore, more efficient and scalable methods are needed to translate quantum algorithms into executable forms on a quantum computer. To overcome these challenges, several research efforts are underway to develop scalable noise-aware quantum compilation approaches that can …
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