Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 54 for “"scaffolding protein"”.
-
Functions of scaffolding protein in phage P22 capsid assembly and maturation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
-
Identifying a role for the scaffolding protein IQGAP1 in liver health and disease
… is focused on understanding the role of the scaffolding protein IQ motif-containing GTPase-Activating Protein 1 (IQGAP1), an evolutionarily conserved scaffolding protein that is frequently up-regulated in liver disease, in the liver’s response to nutritional and cholestatic stress as well as …
-
The Role of the Scaffolding Protein INAD in Localization of Signaling Complexes to the Rhabdomeres of Drosophil Photoreceptors
Organization of proteins into macromolecular complexes is one way cells maximize the speed, specificity, and efficiency of signal transduction. In fruit fly photoreceptors InaD, a scaffolding protein containing 5 PDZ domains, organizes proteins involved in the visual signaling pathway into …
-
The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
Alterations in the strength of glutamatergic synaptic activity shape the synaptic localization of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs), and this process is thought to underlie higher brain functions such as learning and memory. During …
-
The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
… I IFN induction. We propose that DDX3X acts as a scaffolding protein that brings together IKKα and its substrates.
-
The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… initiating capacity through the ability of the scaffolding protein NEDD9 to unite the TGFβ/SMAD and Rho-Actin-SRF pathways. Previously, oncogenicity has been ascribed to the level of NEDD9 protein expression. However, my analysis indicates this mediation by NEDD9 is irrespective of NEDD9 protein …
-
Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… IKKα and IKKβ and the catalytically inactive scaffolding protein IKKγ/NF-κB Essential Modulator (NEMO). The complex can be assembled in multiple conformations as either hetero- or homo-dimers of IKKα/β with or without the scaffolding protein IKKγ. This regulates NF-κB signalling and related …
-
A role for the Spemann organizer gene, Goosecoid, in tumor metastasis
… induces the expression of E- cadherin SIP 1, scaffolding protein IQGAP 1, and PDGF signaling components, all which have independently been implicated in tumor metastasis. Moreover, Goosecoid significantly enhanced the ability of breast cancer cells to form pulmonary metastases in mice. These …
-
Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… regulator (CFTR) comprise of network of proteins that can regulate cAMP-/cGMP-activated CFTR chloride channel function. We report the physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in …
-
Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
Tks5 is a Src tyrosine kinase substrate and scaffolding protein for specialized cytoskeletal structures called podosomes/invadopodia. My doctoral thesis has focused on how Tks5 regulates the formation of these related structures and their impact on the invasive phenotype of cells. The podosomes of …
-
A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
… suggested that NHERF1, a PDZ domain containing scaffolding protein, preferred to interact with CXCR2 and its downstream effector, PLC-β3 in EPCs. Taken together, the data has demonstrated the role of CXCR2 PDZ motif-mediated macromolecular complex in EPC homing and angiogenesis and also …
-
The Novel Role of Dnmbp In Kidney Development
… we examine the role of the exocyst-associated scaffolding protein, Dynamin binding protein (Dnmbp), during junction assembly in epithelializing nephric tubules. We show that disruption of Dnmbp affects adhesion and junctional integrity of nephron progenitor cells by significantly reducing …
-
Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis
The scaffolding protein anillin plays a crucial role during cytokinesis – the physical separation of daughter cells following chromosome segregation. Anillin binds filamentous F-actin, non-muscle myosin II and septins, and in cell culture models has been shown to restrict actomyosin contractility …
-
The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
Precise localization of synaptic proteins is required for proper synaptic function, which is compromised in many neurodevelopmental and neurodegenerative diseases. Since proteins that reside at the active zones are used most frequently during synaptic transmission, they must be continuously …
-
Synaptic Protein Profiling in the Mammalian Brain
… through the precise localization of synaptic proteins, yet it has not previously been possible to analyze the protein content of an individual class of synapses. In order to achieve this, we have used the BAC (bacterial artificial chromosome) transgenic approach to target particular neurons …
-
Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… highlighted a possible role for β-arrestin-2, a scaffolding protein that mediates G-protein coupled receptor desensitization, in channel regulation. Interestingly, β-arrestin-2 also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important nociceptive marker. …
-
Characterization of the zebrafish zipper interacting protein kinase homolog
… of 6 zebrafish Zipper Interacting Protein Kinase homolog has helped to better understand how changes in cell cytoskeletal elements can lead to changes in cell shape and movement. Zebrafish are ideal model organisms for studying ZIPK because it has been previously shown that …
-
Identification of echinus and characterization of its role in Drosophila eye development
… were sequenced. echinus encodes a ~180kDa protein containing an ubiquitin hydrolase domain at its N-terminus and a polyglutamine tract at its C-terminus. echinus is expressed in the retina during pupal development and mutants of echinus have decreased levels of apoptosis during several …
-
Structure of the LKB1-STRAD-MO25 tumour suppressor complex
… to understanding the functional roles of the protein encoded by the LKB1 gene. LKB1 is a Ser/Thr kinase that is activated by binding to the pseudokinase STRAD and the scaffolding protein MO25. LKB1 activates AMPK and twelve other members of the AMPK family of kinases, thus controlling cellular …
-
Insulin-like growth factor receptor activity in cancer biology & therapy responses
… cell migration, interaction with the scaffolding protein RACK1 in the context Integrin signalling, and IGF- 1R kinase activity. Here we investigated the phosphorylation of the SFYYS motif and characterise the conditions under which this motif may be phosphorylated under. As …
Page 1 of 3