Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"scRNA-seq analysis"”.
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Using heterogeneous Graph Neural Networks(hGNN) to predict cell-cell communication
… cellular interactions using single-cell RNA sequencing (scRNA-seq) data. We evaluate the performance of Graph Neural Networks (GNNs) both with and without gene-gene edges, Contrastive Learning, and Variational Autoencoders (VAEs) across multiple datasets. Our study compares these methods and …
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UNCOVERING IMMUNE EVASION MECHANISMS FOR THE PROGNOSIS AND THERAPY OF ENDOMETRIAL AND OVARIAN CANCERS
… of γδ T cells in EC. Flow cytometry analysis reveals that Vδ1 is the primary subset of γδ T cells infiltrating EC lesions in both early and advanced stages. Upon in vitro stimulation, these cells maintain their functional activity by producing cytokines, such as interferon (IFN)-γ and …
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Modeling sources of variation to interpret single cell transcriptomic maps
… for studying biological systems. Single-cell RNA sequencing profiles thousands of individual cells and captures coexisting gene expression programs within a cell. Analyzing data from multiple samples and conditions introduces additional biological variability, including genetic background, age, …
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3D Nanoscale Architecture and Physiology of the Human Airway Epithelium
… remodelling were accompanied by single-cell RNA sequencing (scRNA-seq) analysis, which revealed Gene Ontology (GO) enrichment of pathways related to oxidative phosphorylation (OXPHOS), alongside increased expression of genes involved in mitochondrial fatty acid oxidation (FAO) and glycogenesis. …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… for host-directed therapy, 10x single cell RNA sequencing (scRNA-seq) of M. avium infected THP-1 macrophages was performed, revealing for the first time the heterogeneity in the host response; i.e, several large cell clusters showing different degrees of an inflammatory response, as well as a …
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Head and protocerebral patterning in the spider Parasteatoda tepidariorum
… in five putative anterior cell clusters from scRNA-seq analysis at three embryonic stages of P. tepidariorum (Leite et al., 2024). I found two clusters corresponded to the pedipalpal segment, two clusters corresponded to the pre-cheliceral region: a six3- expressing anterior and …
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The Contribution of Environmental Cues to Early Squamous Tumour Formation in the Upper Gastrointestinal Tract
… of oesophageal tumours. Deep tissue imaging analysis revealed a reduction in the number of tumours and KRT17 clusters in the presence of DN-Maml1 clones compared to controls, confirming the protective phenotype of DN-Maml1. The stress markers, KRT17 and SOX9, were upregulated at the outside …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… gene expression by binding to specific AU-rich sequences located in the 3'-untranslated regions (3’-UTR) of mRNAs and accelerating their decay. Unique among the three, ZFP36L2 plays a pivotal role in maintaining hematopoietic stem cells (HSC) during development. ZFP36L2-deficient mice exhibit …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
… RT-PCR and WB, respectively. Single-cell RNA sequencing (scRNA-seq) dataset of prostate from WT and Ptenpc-/-, either castrated or not, was analysed to assess immune infiltration and metabolic pathway enrichment both in prostate epithelial and immune cells. Results. Both plasma-derived and …