Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"scATAC-seq"”.
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Leveraging Single-Cell ATAC-Seq for Genomic Language Models and Multimodal Foundation Models
… Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) has emerged as a powerful tool for profiling chromatin accessibility at single-cell resolution. By capturing epigenomic landscapes, scATAC-seq provides critical insights into the regulatory elements that govern gene …
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A Transformer for scATAC-scRNA Translation
scATAC-seq gives a comprehensive picture of the chromatin accessibility profile of a cell, covering not only protein-coding regions but also non-coding regulatory regions which are in theory missed by scRNA-seq. However, scATAC-seq data is highdimensional and noisy, aspects which when compounded …
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Multi-omic Analysis of Neurodegeneration in Alzheimer’s Disease and Related Dementias
The advent of single cell sequencing has revolutionized the granularity at which we can understand genetics and underlying cell biology. This enables us to analyze both the transcriptome and epigenome of various tissues, offering new insights into the molecular mechanisms that underlie disease such …
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Knowledge-Guided Machine Learning for Single-Cell Regulatory Genomics
… coordinate gene regulation, and single-cell sequencing now enables these programs to be studied at high resolution. However, single-cell RNA-seq and ATAC-seq data are sparse and high-dimensional, making it difficult for existing methods to reliably infer TF activity and gene-regulatory …
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Droplet-Based Microfluidics for High-Throughput Single-Cell Omics Profiling
… techniques to accomplish high-throughput scRNA-seq, scDNA-seq, scATAC-seq, scChIP-seq, as well as scMulti-omics-seq. These advanced technologies have been providing unique and novel insights into both normal differentiation and disease development at single-cell level. In this thesis, we develop …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… epithelial cells was used. single cell RNA sequencing (scRNA-seq) was performed to track the phenotypic evolution of Vhl / Pbrm1 null cells towards early carcinomas. The first transition was seen 10 months after Vhl / Pbrm1 inactivation with upregulation of stress- related transcription …
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Molecular analysis of germ cell specification
… unknown. Here we use single cell omics (scRNA-seq and scATAC-seq) to characterise the progressive alterations in gene expression and chromatin readout at short time intervals during in vitro germline specification. Our results establish distinct trajectories for the specification of early …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
… (LSK-) subpopulation were profiled via bulk RNA-seq, single-cell RNA-seq (scRNA-Seq), and single-cell ATAC-seq (scATAC-Seq). The integrated analysis revealed that PML-RAR expression maintains largely unaltered the overall transcriptional program of pre-leukemic cells, while driving cell cycle …
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Probabilistic models to resolve cell identity and tissue architecture
… assay for transposase-accessible chromatin with sequencing (ATAC-seq), DNA accessibility provides a readout of intermediate gene regulation steps at single-cell resolution, with technologies measuring both RNA and ATAC providing the necessary evidence to build mechanistic models of regulation. …
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Resolving developmental dynamics using single-cell sequencing data
… in disease. Over the past decade, single-cell sequencing has become one of the key technologies to generate high resolution in vivo snapshots to study developmental trajectories. After giving an overview of the current state of single cell technologies and computational methods, I continue with …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
… of the stepwise role that these TFs play in sequence for developing blood and mesoderm allows for a better understanding of the consequences of genetic mutations. To perform this analysis, we generate a series of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated …