Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"satellite cell"”.
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The Satellite Cell of Skeletal Muscle
… unique feature of the skeletal muscle fibre, the satellite cell. This small fusiform cell, lying in a subsarcolemmal position, is the most recently discovered cytological entity of skeletal muscle. It can be readily distinguished from other better-known mononuclear cells found lying between muscle …
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The Role of Oxytocin in Bovine Satellite Cell Proliferation and Differentiation
… is possible that OXT may play essential roles in satellite cell (SC) proliferation and differentiation, which further contribute to skeletal muscle development and growth. In this dissertation, we tested this hypothesis with in-vivo and in-vitro studies in intrauterine growth restriction (IUGR) …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… and disease. In muscle regeneration, satellite cells (SCs) are essential for new muscle fiber formation; however, they lose their native quiescent state upon isolation, making in vitro studies of human SC function challenging. To optimally promote SC quiescence and enable exploration …
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
… that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. Current research also suggests that T cells of the immune system may influence skeletal muscle repair via signaling with MPCs. The objective of the present study was to examine the influence of …
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The effects of furosemide on equine skeletal muscle satellite cell myogenesis and metabolism in vitro
… various doses of furosemide may have on equine satellite cell (eqSC) myogenesis and metabolism. Mitotic index was increased (P<0.05) as a result of treatment with 100 µg/mL furosemide, a 10-fold pharmacological dose, in comparison to vehicle, but was not different (P>0.05) compared to the …
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Defining the Role of Pannexin1 in Skeletal Muscle and Satellite Cell Function in vivo and ex vivo Using a Novel Conditional Knockout Mouse Model
… these mice were observed to have fewer quiescent satellite cells (SCs) with a reduction in commitment to the myogenic lineage and a decline in fusion capabilities. Additionally, Panx1 was found to be preferentially localized among fiber-types leading to smaller type I fibers in the SOL of male …
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Aging Skeletal Muscle Plasticity in Exercise and Injury
… after muscular injury. Activity of muscle stem cells, termed satellite cells, is dysregulated with aging which impairs skeletal muscle remodeling and limits plasticity of aged muscle. Aim 1 (Chapter 2) of this dissertation seeks to clarify the debated requirement of satellite cells for …
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Optimizing Ex Vivo Culture of Satellite Cells
Satellite cells are responsible for regeneration of skeletal muscles. They have the ability to form new muscle fibers and to repopulate satellite cell pool. Transplantation of human satellite cells to muscle dystrophy patients is an aim. To achieve this aim, we must understand mechanisms governing …
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Nutritional Strategies to Improve Pig Growth and Performance
… nutrient restriction possibly due to altered satellite cell activity which can permanently alter growth potential. Therefore, optimal nutrition is important for maximizing the growth potential of the animal. Heat stress leads to changes in digestion and metabolism, thus alters nutrient …
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The role of myostatin during postnatal myogenesis and sarcopenia
… resulting from an impaired propensity of satellite cells to activate and a subsequent decline in myogenesis. Myostatin is a known inhibitor of postnatal satellite cell activation and muscle regeneration, thus muscle mass and regeneration, and satellite cell behaviour were examined in young …
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The Relationships of Age, Physical Activity Level, Adiposity, and Diet, with Human Satellite Myogenesis, and Metabolism
In healthy individuals, satellite cells are partly responsible for muscle repair and preventing atrophy. Previous studies have linked the loss of muscle mass associated with aging to satellite cell dysfunction, postulating that satellite cell function diminishes with age. New evidence suggests that …
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Cellular and molecular regulation of skeletal muscle regeneration
… provides a powerful model to study the cellular and molecular mechanism governing stem cell function since the whole process is mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles of Notch signaling …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
Satellite cells are normally a quiescent skeletal muscle stem cell pool that upon activation rapidly proliferate and differentiate to repair damaged muscle fibers. The paired box transcription factor 7 (Pax7) is the canonical biomarker for quiescent, activated, and proliferating satellite cells and …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… have provided evidence that mesenchymal stem cells residing in skeletal muscle (mMSCs) contribute to repair following injury by secreting a variety of factors that are important for progenitor cell (satellite cell) activation. Our lab has also previously established that mMSC proliferation and …
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Regulation of human satellite cells in vitro via inflammatory cytokines and myogenic transcription factors across proliferation and differentiation
… losses in skeletal muscle mass. Mononuclear stem cells, termed satellite cells, are mitotic and serve to donate nuclei to muscle fibers to enable skeletal muscle adaptation. Despite the well-characterized nature of satellite cell activation, proliferation, and differentiation, the underlying …
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Exploring metabolic and molecular mechanisms regulating age-related declines in human skeletal muscle regenerative capacity.
… exercise induced anabolic signalling and satellite cell activation, prior to and at the nadir of force, respectively. Compared to the younger adults, ageing per se was associated with increased inflammation, whilst anabolic and catabolic signalling post-eccentric and concentric exercise …
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Impact of Leucine and HMB on Acute Muscle Damage: Focus on Repair and Regeneration in vivo and in vitro
… are capable of regeneration after injury. The satellite cell is the driving factor for muscle regeneration, influenced by their internal and external environment. The majority of these processes and factors are impaired with age, in particular, the function of the satellite cell. Interventions …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
… the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity and functional …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… of MyoD, a key myogenic gene, in muscle stem cells. Furthermore, loss-of-function of this protein, mediated by RNA interference, has implicated Six1 as essential towards normal myogenic differentiation. However, beyond Six1 and its involvement towards myogenesis, our data also suggests the …
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Muscle Growth and Development in Intrauterine Growth Restricted Pigs
… project were to: 1) determine muscle stem cell characteristics in IUGR pigs; 2) determine how intrauterine growth restriction alters protein deposition in skeletal muscle; 3) investigate whether branched-chain amino acids (BCAA) are able to enhance protein synthesis in intrauterine growth …
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