Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"sarcosphere"”.
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The role of autophagy in canine osteosarcoma
… that these migratory bodies are early sarcosphere or sarcosphere precursors that may contain tumour-initiating cells and could mimic the early stages of metastasis. Formation of migratory bodies was directly proportional to the number of cells plated, and these migratory bodies …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… display high aldehyde dehydrogenase activity and sarcosphere formation under limited nutrient media and anchorage independence. These markers are not feasible targets for therapy due to their expression on normal tissue stem cells; however, upstream regulators of this phenotype may be targetable. …
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… drug discovery. Our lab also used 3-D spheroids (sarcospheres) that mimic in vivo tumors. In initial drug screens, our lab identified romidepsin, a histone deacetylase inhibitor, as a potent inhibitor of viability of highly metastatic osteosarcoma sarcospheres that was non-toxic to normal cells. …