Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"sarcosine"”.
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Enzyme-Linked Electrochemical Detection of Urinary Sarcosine
… that may be useful in PCa diagnostics is urinary sarcosine (N-methylglycine). However, its utility is confounded by several factors: the small differences in metabolite concentration that separate healthy (~ 0.2 µM) and sick (~ 5.0 µM) patient populations, the difficulties associated with …
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Lysine and Glycyl-L-Sarcosine Absorption Across Ovine Forestomach Epithelium In Vitro
… plateaued. Using omasal epithelium, glycyl-L-sarcosine (Gly-Sar; .1 mM) absorption was studied during co-incubation with glycine and peptide substrates (each at 5 mM). Accumulation of Gly-Sar in omasal epithelium was greatest (P < .05) when Gly-Sar was present alone. Glycine inhibited (P < …
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Characterization of Glycyl-Sarcosine Uptake by Ovine Intestinal Brush Border Membrane Vesicles
… in the ovine small intestine, [14C]-glycyl-sarcosine uptake by tissue collected from five sheep was studied through the use of brush border membrane vesicles (BBMV). Preliminary experiments determined that incubation in hyaluronidase is not necessary in order to separate mucosal tissue from …
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Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis
… and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode potentiometry and isothermal titration calorimetry at 25 °C and an ionic strength 0.15 M (NaCl). The …
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Development of a ReaxFF force field for glyphosate and investigation of its abiotic degradation pathways
… (44.1, 44.3) kcal/mol for the C-P bond breaking sarcosine pathway, C-N bond breaking GLY/MPA pathway, and C-N bond breaking AMPA pathway respectively. The C-P bond breaking energies are in close agreement with the previously reported DFT value of 21.8 kcal/mol. The GLP- simulations did not reveal …
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Development of dermally absorbed copper(ii) complexes as potential anti-inflammatory drugs
… of administration is dermal absorption and so sarcosine was added to improve the lipophilicity of the drug. This administration method was chosen since it is both nonharmful and convenient for patients. The stability of the complexes was measured using glass electrode potentiometry and their …
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Synthesis, structure and chirality of some neutral cobalt (III) complexes
… cobalt(III) where the amino acid is sarcosine, S-proline and S-serine. A convenient, high yield synthesis of tris(2 ,4-pentanedionato)-rhodium(III) is reported.</p>
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Metabolomic profiling to investigate effect of curcumin in lung cancer
… Some of these metabolites such as glycine, sarcosine , and alanine have been previously reported to be increased in other cancer types like prostate. These could potentially serve as potential biomarkers of cancer in general. In addition, some metabolites may be of specific relevance to …
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Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
… to determine modified nucleosides, CoAs, and sarcosine, proline, kynurenine, uracil and glycerol-3-phosphate. These methods were applied to measure the above mentioned analytes in either urine samples or cell extracts and proved to be simple, fast, reliable and powerful. Based on these newly …
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Part 1: Isolation of Orexin Receptor Regulators via a Microarray-Based,Two-Color Cell Binding Screen. Part II: Targeted Inactivation of Proteins triggered by Visible Light.
… a hit peptoid can be rapidly identified through sarcosine scanning. Subsequent modifications of the pharmacophore yielded a potent antagonist (IC50 = 1.7 ? and an allosteric potentiator (EC50 = 120 nM) of the orexin receptor. Part II. Targeted Inactivation of Proteins Triggered by Visible Light …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
… two analytical methods for the determination of sarcosine in urine for the early detection of prostate cancer. The next three papers discuss the analytical challenges facing the determination of pteridine derivatives in biological samples and present a new method to adjust their levels to patient …
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Microbial Evolution In Sea Ice: Communities To Genes
… growth of C. psychrerythraea strain 34H on sarcosine (a derivative of glycine betaine) as a sole carbon and nitrogen source suggested that the laterally transferred genes were expressed in vitro.
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
… identification studies using alanine/sarcosine scans. These studies revealed that residues 1–4 and 8 (from the C-terminus) are not important and those residues 5–7 are important for the direct binding of JM3A to CSV. We then found that our previous N-terminal benzophenone(BP)-coupled …
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Biosensor design utilizing particle-bound enzymes
There is a clear need for affordable point-of-care diagnostics, especially in vulnerable low- and middle-income countries where access to laboratory-based testing is limited. This thesis explores whether recombinant protein technology in combination with a low-cost support matrix could provide a …