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Showing 1 to 20 of 89 for “"sarcoplasmic reticulum"”.
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The Effect of Glycogen Depletion on Sarcoplasmic Reticulum Function
… by the release and uptake of Ca²⁺ from the sarcoplasmic reticulum (SR). Force production is proportional to [Ca²⁺], as [Ca²⁺] increases so does force. At the point of fatigue, there is a decrease in force production. Since fatigue has been associated with glycogen depletion, it is likely …
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The Function Of Sarcoplasmic Reticulum In The Aged Rat Heart
… of Ca{dollar}sp{lcub}2+{rcub}{dollar} by cardiac sarcoplasmic reticulum (SR) and its potential contribution to the age-related alterations in myocardial contractile performance in Fischer 344 rats.;In cardiac membranes enriched in SR (MSR) and its light (LSR) and heavy (HSR) subfractions …
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Characterization of the sarcoplasmic reticulum calcium release channel in skeletal muscle
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Photoaffinity labeling the nucleotide sites of the sarcoplasmic reticulum Ca²⁺-ATPase
… and characterized their interaction with the sarcoplasmic reticulum Ca²⁺-ATPase. The TNP-8N₃-nucleotides were synthesized from ATP in three steps involving bromination in the 8-position of the adenine ring followed by displacement with an azido group and then trinitrophenylation of the …
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Glycogen extraction from skeletal muscle sarcoplasmic reticulum: structural and functional implications
In this investigation, skeletal muscle sarcoplasmic reticulum (SR) was purified from female Sprague Dawley rats (200-250 g). SR samples were subjected to two different biochemical glycogen-extraction protocols. The results suggest that both amylase and removal of EDTA (No-EDTA) from the …
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The Effects of Lactate on Whole Muscle Function and Sarcoplasmic Reticulum Function
… were due to alterations in the sacroplasmic reticulum (SR) Ca2+ exchange. The SR of EDL homogenates were actively loaded with Ca2+ and release was initiated by 25 mM AgNO3. The rate of Ca2+ release was significantly reduced by 31% (2.48 ± 1.21 vs 1.72 ± 0.24 mmol·mg-1·min-1) in the presence …
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Effects of altered physical activity on human skeletal muscle sarcoplasmic reticulum calcium regulation
The sarcoplasmic reticulum (SR) regulates intracellular calcium and therefore largely determines the rates of contraction and relaxation in skeletal muscle. However, little is known about SR function in human skeletal muscle. This thesis therefore investigated several factors that could potentially …
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Properties of the nucleotide binding sites of the Ca²⁺-ATPase of sarcoplasmic reticulum
… site of the Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum have been investigated. The study centred around interaction of the high affinity ATP analog, 2'-3'-0-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate, (TNP-ATP), with the Ca²⁺-ATPase. Defined fractions of the sarcoplasmic …
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Conformational changes in the (Ca²⁺, Mg²⁺)-ATPase of sarcoplasmic reticulum during energy transduction
Treatment of SR membranes with mild acid (pH 5.6) (Berman, M.C., McIntosh, D.B. and Kench, J.E. (1977) J. Biol. Chem. 252, 994-1001) or incubation with millimolar concentrations of ethylene glycol bis (β-aminoethyl ether)-N ,N'-tetraacetic acid (EGTA) at neutral pH and 37°C (McIntosh, D. B. and …
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Effects of Reduced Muscle Glycogen on Sarcoplasmic Reticulum (SR), Muscle and Exercise Performance
… and 90% less glycogen associated with the sarcoplasmic reticulum (SR) than the HG group. Notably, time to exhaustion during a subsequent treadmill run (21 m/min at 10% grade) was markedly lower in the LG group (35 vs. 166.75 min). Despite less glycogen, the LG group had a higher SR Ca2+ …
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Sarcoplasmic reticulum responses to repeated sprints, conditioning and dietary lecithin in the horse
Sarcoplasmic reticulum (SR) releases and sequesters calcium during muscle contraction and relaxation. Calcium uptake rates have been shown to respond to high intensity exercise, and we propose this response may be affected by conditioning and dietary lecithin. Ten Quarter Horses performed repeated …
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The effect of fatigue on the caffeine sensitivity of skeletal muscle sarcoplasmic reticulum
Several studies have shown that the loss in tension during fatigue can be virtually reversed by exposure of the muscle to agents which evoke Ca²⁺ release from the SR. The purpose of this study was to determine whether the SR Ca²⁺ release mechanism of fatigued muscle is less sensitive to caffeine …
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Junctional Sarcoplasmic Reticulum Protein Processing And Trafficking In Cardiac Tissue And Primary Cultured Cardiomyocytes
<p>Junctional SR is an important and unique ER subdomain in the adult myocyte that releases Ca2+ through the actions of an exclusive set of resident proteins. Cardiac calsequestrin (CSQ2) undergoes two co-translational modifications: N-linked glycosylation on 316Asn, and phosphorylation by protein …
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Coronary artery disease in metabolic syndrome: a role for the sarcoplasmic reticulum Ca2+ ATPase
… Ki-67 staining. In particular, alterations in sarcoplasmic reticulum (SR) Ca2+ store together with altered function of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) were associated with induction of proliferation. Organ culture of coronary arterial segments revealed that culture-induced …
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The Role of Potassium as a Counterion During Calcium Release From the Sarcoplasmic Reticulum
… release on the electrical properties of the sarcoplasmic reticulum (SR) membranes since a voltage change may play an important role in muscle regulation. Hence the role of K$\sp{+}$ as a counterion during Ca$\sp{2+}$ release from the SR was investigated and found to be physiologically …
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Properties of the non-catalytic nucleotide site of the Ca²⁺-ATPase of sarcoplasmic reticulum
… site of the Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum have been investigated. Previously, several lines of evidence have indicated the existence of both catalytic and regulatory nucleotide binding sites on the same polypeptide species. The present study concentrates on the …
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Sarcoplasmic Reticulum Calcium Handling in Maturing Skeletal Muscle From Two Models of Dystrophic Mice
… is that disrupted calcium (Ca²⁺) handling by the sarcoplasmic reticulum (SR) leads to an increased cytosolic Ca²⁺ concentration that activates proteolytic and apoptotic pathways that initiate muscle fiber death. However, little is known about the role of disrupted SR function in the onset of DMD. …
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